Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1094584..1095236 Replicon chromosome
Accession NZ_CP050296
Organism Mesorhizobium huakuii strain 583

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HB778_RS05430 Protein ID WP_183462116.1
Coordinates 1094847..1095236 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HB778_RS05425 Protein ID WP_095204197.1
Coordinates 1094584..1094850 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB778_RS05410 1090118..1090564 - 447 WP_183462112.1 YcgN family cysteine cluster protein -
HB778_RS05415 1090763..1093017 + 2255 Protein_1076 OmpA family protein -
HB778_RS05420 1093534..1094400 - 867 WP_183462114.1 NAD(P)-dependent oxidoreductase -
HB778_RS05425 1094584..1094850 + 267 WP_095204197.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
HB778_RS05430 1094847..1095236 + 390 WP_183462116.1 type II toxin-antitoxin system VapC family toxin Toxin
HB778_RS05435 1095243..1095869 - 627 WP_183462118.1 helix-turn-helix transcriptional regulator -
HB778_RS05440 1095878..1096750 - 873 WP_183462120.1 S1C family serine protease -
HB778_RS05445 1096919..1097869 + 951 WP_183462122.1 trypsin-like peptidase domain-containing protein -
HB778_RS05450 1097879..1098304 - 426 WP_183462124.1 VOC family protein -
HB778_RS05455 1098371..1098997 + 627 WP_183462126.1 TetR/AcrR family transcriptional regulator -
HB778_RS05460 1098930..1099886 - 957 WP_183462127.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-123)

Antitoxin

Antitoxin VapB-like

(1-86)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14242.45 Da        Isoelectric Point: 5.7222

>T152475 WP_183462116.1 NZ_CP050296:1094847-1095236 [Mesorhizobium huakuii]
MIIDSSALVAILRLEPGYERFVLAITQANRRLLAAPTYLETTMVLAGGRQDEILDRLDTFLRTASIETIPFTADHAAVAR
QAFLRYGKGRHPAALNFGDCIAYATARLEAMPLLFKGDDFRLTDIEAAV

Download         Length: 390 bp

>T152475 NZ_CP066190:52880-53452 [Bacillus cytotoxicus]
TTGGCTAATAAAGATAATCCTAAATTCTATACGATTTCAACTAAATATATAGACTATCTAAGGGAAACAGATAATAAAGT
GCCCTTTAATAAAGATGAACAGCATAGTAGACCGTATGTAGGCGTATTGGAAAAAATCAATGGTCATGATTATTTTGTTC
CTTTAACATCACGTAATGATAAAAACTTTAATAGCCAGGTCAGTGTGAAATTATTCGATAAAGATAACCCTGAAAAGCGA
ATTGGAGTTTTATTAGTCAATAACATGATTCCAGTCCCAGAAAAAGAGTGTAAAGAAATTGATATAGCAGAAAAAATGGA
GACAGATCCTAAGTATGGTAATTTGATGTTAAAACAGTATTTGTTTTTAAAAGAGAATATGGATCGACTTTCTCATAAAG
TGGAAAAAGTATATAAAGATGTAACTGTACAAGGAAAGCCATCAAAAAAACAGAAATTTCTAAAGGGAATTTGCTGTGAC
TTCTCAACATTAGAAGAAAAGTGCCAGGAATATAAAGAGAAGAATCAAGCTAGAAGAATAGCATATATGCGTCAAATGGG
GCGTGAAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10085.44 Da        Isoelectric Point: 4.6168

>AT152475 WP_095204197.1 NZ_CP050296:1094584-1094850 [Mesorhizobium huakuii]
MALSIKNMEVEQLARELARRRHVSVTEAIRQSLEREVARERLVPREDASDLFQRLMAIADSAGKIPEREDAMTDDEILGY
DEFGIPTK

Download         Length: 267 bp

>AT152475 NZ_CP066190:52722-52818 [Bacillus cytotoxicus]
GTAGCCTTACTTTAGTAGGCGCGAAAAAATTGGTGTAACTCTACCGTAGTGAGTACCAAAAAATTGGTGTAGCCTTACCG
TAGTAGGCACAAAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References