Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 857022..857617 Replicon chromosome
Accession NZ_CP050296
Organism Mesorhizobium huakuii strain 583

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag HB778_RS04185 Protein ID WP_183461718.1
Coordinates 857022..857210 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HB778_RS04190 Protein ID WP_183461719.1
Coordinates 857216..857617 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB778_RS04165 852226..852708 + 483 WP_210308077.1 flagellar basal body-associated protein FliL -
HB778_RS04170 852904..853920 - 1017 WP_183461714.1 ABC transporter permease -
HB778_RS04175 853917..855494 - 1578 WP_183461716.1 sugar ABC transporter ATP-binding protein -
HB778_RS04180 855726..856673 - 948 WP_096448447.1 substrate-binding domain-containing protein -
HB778_RS04185 857022..857210 + 189 WP_183461718.1 type II toxin-antitoxin system HicA family toxin Toxin
HB778_RS04190 857216..857617 + 402 WP_183461719.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HB778_RS04195 857653..858351 + 699 WP_183461721.1 RibD family protein -
HB778_RS04200 858364..859248 - 885 WP_183461723.1 SDR family oxidoreductase -
HB778_RS04205 859338..860169 + 832 Protein_835 helix-turn-helix domain-containing protein -
HB778_RS04210 860197..860643 - 447 WP_183461725.1 SRPBCC domain-containing protein -
HB778_RS04215 860640..861422 - 783 WP_210308061.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-124)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7089.21 Da        Isoelectric Point: 11.6118

>T152473 WP_183461718.1 NZ_CP050296:857022-857210 [Mesorhizobium huakuii]
MNSADIIRLLQADGWFEVARKGSHAQFKHRDKQGRVTVPHPKRDIPIGTLRSIEKQSGLKLR

Download         Length: 189 bp

>T152473 NZ_CP066187:1757995-1758345 [Bacillus cytotoxicus]
TTGATTGTAAAACGCGGCGACGTGTATTTTGCAGACCTTTCCCCAGTTGTTGGTTCTGAGCAAGGAGGCGTTCGTCCGGT
TCTTGTCATTCAAAATGACATCGGAAATCGTTTTAGTCCGACTGTGATTGTAGCAGCGATTACTGCACAGATTCAAAAAG
CAAAATTGCCCACGCATGTGGAGATTGATGCGAAGAAGTACGGATTTGAGAGAGATTCTGTGATCTTGCTCGAGCAGATT
CGAACAATTGATAAGCAACGCTTAACGGACAAAATCACACATTTAGATGAAGTGATGATGATTCGTGTAGATGAGGCTTT
ACAAATTAGTTTAGGACTAATAGATTTTTAA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14183.97 Da        Isoelectric Point: 4.3383

>AT152473 WP_183461719.1 NZ_CP050296:857216-857617 [Mesorhizobium huakuii]
MKQYIGLIHKDAGSDFGVSFPDFPGVITAGKDLDDARSMAEEALALHIEGLVEDGEAIPEPSSLEAVMADADNRDGVAIL
VAARTEARKAVRINVTLPDDVLRRIDAFAEAHGYTRSGFLAKAAEKAMELESA

Download         Length: 402 bp

>AT152473 NZ_CP066187:1757703-1757990 [Bacillus cytotoxicus]
GTGTCCGAATCAAGTGTAACTACTGAAATCGTGGTTCGGTTGCCAAAGCAAGTGGTGACGGAATTGGACGGGATTGGAAA
ACAAGAGAATAAGAATCGCCATGAACTAATTTGCCAGGCAACACAACTGTTATTGCGTCAACATAAGACGAAAAAACGCT
ACCAACATGAATCAATGCGACGTGGGTACATTGAAATGGGAAAAATTAATCTTGGTATTGCATCTGAAGCTTTCTTAGCA
GAGTATGAAGCAGCTCATACAGTAGAACGCTTAGTAAGCGGGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References