Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 5184777..5185420 Replicon chromosome
Accession NZ_CP050292
Organism Tardiphaga robiniae strain 581

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HB776_RS24775 Protein ID WP_184520103.1
Coordinates 5184777..5185166 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HB776_RS24780 Protein ID WP_184512614.1
Coordinates 5185181..5185420 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB776_RS24755 5180006..5180860 - 855 WP_184512609.1 hypothetical protein -
HB776_RS24760 5181825..5182925 - 1101 WP_184512611.1 pyrimidine utilization protein A -
HB776_RS24765 5183108..5183905 + 798 WP_184512612.1 class I SAM-dependent methyltransferase -
HB776_RS24770 5184071..5184748 + 678 WP_089266426.1 PilZ domain-containing protein -
HB776_RS24775 5184777..5185166 - 390 WP_184520103.1 type II toxin-antitoxin system VapC family toxin Toxin
HB776_RS24780 5185181..5185420 - 240 WP_184512614.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HB776_RS24785 5185481..5186842 - 1362 WP_184512616.1 trypsin-like peptidase domain-containing protein -
HB776_RS24790 5187077..5187877 + 801 WP_184512618.1 molybdopterin-synthase adenylyltransferase MoeB -
HB776_RS24795 5187935..5188936 - 1002 WP_184512620.1 aldo/keto reductase -
HB776_RS24800 5189055..5190008 + 954 WP_093757898.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

SpoVT-AbrB domain

(10-47)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14178.54 Da        Isoelectric Point: 8.7647

>T152470 WP_184520103.1 NZ_CP050292:c5185166-5184777 [Tardiphaga robiniae]
MLDTNIVSDLIRNPAGRAAKRIRKVGTDGLCVSIITSAELRFGCAKRNSPRLTQLVEQVLNELDILPLESPTDIEYARIR
HNVEKKGIPIGPNDLLIAAHACAIDATLVTANAKEFKRVPGLKVENWLL

Download         Length: 390 bp

>T152470 NZ_CP066184:c3153404-3152664 [Bacillus cytotoxicus]
TTGACTGTCACTAGCGTTCGAATTGGCTTGTTTTTTCTTGTAATCTTTTTTTTATTTCTTATTTTCTTTTATTGGAGAAA
TGAAGAACGATACGAGGAAAGAAAACAACTTATTCGAAAGACGTGGTATGGTTTATTTATTACATCAGTCACAATGTATT
TCATGATGAAAGGAATTGATTTAACCCTCTGGAAACATATTTTAATGGTTGTTGCGATGGTTGTATTTGTTGATATTGCA
TTTATTTTAACGCCAAATATTTCGGAAATCTGGGGCGCAAAGTTTAGTGATATTGGTAAGACAGTTCAATCGATTAAACG
ATCGCTTATTGCTTCAAAAGCAAGAGGAGAAATATATACAACACTTATTCAAAATGTAAATCCAGCTGCATTTGGTACGA
TGGAATGGGAAACAGATGCTGAGTATGCACGCAGTTTAAATGCTTTTCTTGATACGTATGCTGAAAAAATAGGTGCGAAA
ATTGTAGTATTTGTCACAGAAGAGGAATTAAATACAAACTTCCGAGGTGTTCGATCTCAATTTAGTATTACAGTATCACC
CGAATCTATTGAACAACTGAATGAGCAAAAAGCAGTTCAAATTGAAAATGTTGGAATTATACCAGCGAAAATAATAAAAG
ACGTTTATATTATTATGGATGGACAAAAAAATAATTTGCAAGATCGTGACTTTGAAAATGTATATAATTTAACAATACAT
CATAGTTACTTTTGTAAGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9109.42 Da        Isoelectric Point: 5.1239

>AT152470 WP_184512614.1 NZ_CP050292:c5185420-5185181 [Tardiphaga robiniae]
MTDSRHVRLFRNGRNQAVRIPVEFELPGDEAVMHRDGDRLVIEPVRKRGLLALLDTMEPFTEEFPDVDAGLRPLRDVNL

Download         Length: 240 bp

>AT152470 NZ_CP066184:c3152540-3152412 [Bacillus cytotoxicus]
GTGTTAAAAGAATATAGCAATGATTTCTTTAAAGACGAAGCTGAGGATACAACAGATTTTTCTTTAATAAAAGGAGATAC
AATGCAGCAAGTGGAAGAATTAGAAGAAGAATTGAAAAGAAGAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References