Detailed information of TA system TA152468

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4294908..4295424
• Replicon: chromosome
• Accession: NZ_CP050291
• Organism: Pseudomonas plecoglossicida strain PQLYC4

Toxin (Protein)

• Gene name: relE
• Uniprot ID: S2K628
• Locus tag: HAV28_RS19570
• Protein ID: WP_016391633.1
• Coordinates: 4294908..4295195 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: S2KXY3
• Locus tag: HAV28_RS19575
• Protein ID: WP_016391634.1
• Coordinates: 4295185..4295424 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HAV28_RS19565	4293473..4294723	+	1251	WP_016391632.1	ribonucleotide-diphosphate reductase subunit beta	-
HAV28_RS19570	4294908..4295195	-	288	WP_016391633.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HAV28_RS19575	4295185..4295424	-	240	WP_016391634.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HAV28_RS19580	4295682..4297112	+	1431	WP_016391635.1	L-lactate permease	-
HAV28_RS19585	4297130..4298554	+	1425	WP_016391636.1	PLP-dependent aminotransferase family protein	-
HAV28_RS19590	4298555..4299454	-	900	WP_016391637.1	LysR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-84)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-58)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11328.20 Da
• Isoelectric Point: 10.2255

>T152468 WP_016391633.1 NZ_CP050291:c4295195-4294908 [Pseudomonas plecoglossicida]
MTYSLEFDSRALKEWKKLGDTVRQQFKKKLAEILLNPRVEANRLHALPDCYKIKLRSSGYRLVYQVIDKEIVVFVVAVDR
RERDQVYRKAAERLD

Nucleotide

• Length: 288 bp

>T152468 NZ_CP066179:c2969573-2968833 [Bacillus cytotoxicus]
TTGACTGTCACTAGCGTTCGAATTGGCTTGTTTTTTCTTGTAATCTTTTTTTTATTTCTTATTTTCTTTTATTGGAGAAA
TGAAGAACGATACGAGGAAAGAAAACAACTTATTCGAAAGACGTGGTATGGTTTATTTATTACATCAGTCACAATGTATT
TCATGATGAAAGGAATTGATTTAACCCTCTGGAAACATATTTTAATGGTTGTTGCGATGGTTGTATTTGTTGATATTGCA
TTTATTTTAACGCCAAATATTTCGGAAATCTGGGGCGCAAAGTTTAGTGATATTGGTAAGACAGTTCAATCGATTAAACG
ATCGCTTATTGCTTCAAAAGCAAGAGGAGAAATATATACAACACTTATTCAAAATGTAAATCCAGCTGCATTTGGTACGA
TGGAATGGGAAACAGATGCTGAGTATGCACGCAGTTTAAATGCTTTTCTTGATACGTATGCTGAAAAAATAGGTGCGAAA
ATTGTAGTATTTGTCACAGAAGAGGAATTAAATACAAACTTCCGAGGTGTTCGATCTCAATTTAGTATTACAGTATCACC
CGAATCTATTGAACAACTGAATGAGCAAAAAGCAGTTCAAATTGAAAATGTTGGAATTATACCAGCGAAAATAATAAAAG
ACGTTTATATTATTATGGATGGACAAAAAAATAATTTGCAAGATCGTGACTTTGAAAATGTATATAATTTAACAATACAT
CATAGTTACTTTTGTAAGTAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 9012.37 Da
• Isoelectric Point: 4.6437

>AT152468 WP_016391634.1 NZ_CP050291:c4295424-4295185 [Pseudomonas plecoglossicida]
MASINVRVDDELKARAYQELERLGVTPSELMRQALQYVAERGKLPFRPVLMSEEDEDLIATVSERLAAPQRVKVKLDDL

Nucleotide

• Length: 240 bp

>AT152468 NZ_CP066179:c2968709-2968581 [Bacillus cytotoxicus]
GTGTTAAAAGAATATAGCAATGATTTCTTTAAAGACGAAGCTGAGGATACAACAGATTTTTCTTTAATAAAAGGAGATAC
AATGCAGCAAGTGGAAGAATTAGAAGAAGAATTGAAAAGAAGAGGATAA

Structures

Toxin

• AlphaFold DB: S2K628

Antitoxin

• AlphaFold DB: S2KXY3