Detailed information of TA system TA152464

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): SmuAT/-
• Location: 1748468..1749429
• Replicon: chromosome
• Accession: NZ_CP050273
• Organism: Streptococcus mutans strain P1

Toxin (Protein)

• Gene name: smuT
• Uniprot ID: -
• Locus tag: HB750_RS08595
• Protein ID: WP_019314493.1
• Coordinates: 1748914..1749429 (-)
• Length: 172 a.a.

Antitoxin (Protein)

• Gene name: smuA
• Uniprot ID: A0A829BWH5
• Locus tag: HB750_RS08590
• Protein ID: WP_002269854.1
• Coordinates: 1748468..1748914 (-)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HB750_RS08555	1743853..1744275	+	423	WP_018030837.1	hypothetical protein	-
HB750_RS08560	1744278..1745306	+	1029	WP_049473477.1	replication initiation factor domain-containing protein	-
HB750_RS08565	1745365..1745625	+	261	WP_002279804.1	helix-turn-helix domain-containing protein	-
HB750_RS08570	1745694..1746911	+	1218	WP_049473478.1	tyrosine-type recombinase/integrase	-
HB750_RS08575	1747021..1747413	-	393	WP_002262992.1	30S ribosomal protein S9	-
HB750_RS08580	1747438..1747884	-	447	WP_002262993.1	50S ribosomal protein L13	-
HB750_RS08585	1748277..1748471	-	195	WP_002262994.1	helix-turn-helix transcriptional regulator	-
HB750_RS08590	1748468..1748914	-	447	WP_002269854.1	hypothetical protein	Antitoxin
HB750_RS08595	1748914..1749429	-	516	WP_019314493.1	hypothetical protein	Toxin
HB750_RS08600	1749561..1750421	-	861	WP_002265709.1	DegV family protein	-
HB750_RS08605	1750445..1751191	-	747	WP_002264862.1	23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB	-
HB750_RS08610	1751504..1752058	+	555	WP_002262999.1	PadR family transcriptional regulator	-
HB750_RS08615	1752247..1753239	+	993	WP_019804634.1	BtrH N-terminal domain-containing protein	-
HB750_RS08620	1753275..1754012	-	738	WP_002272256.1	MerR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1722507..1758690	36183

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-148)

Antitoxin

• Antitoxin Xre-like, helix-turn-helix domain (30-89)

Sequences

Toxin

Protein

• Length: 172 a.a.
• Molecular weight: 19526.18 Da
• Isoelectric Point: 9.8653

>T152464 WP_019314493.1 NZ_CP050273:c1749429-1748914 [Streptococcus mutans]
MFDLVVNLILLVIVIGGFVFLRFYADKKGKREYDERQLLMQKKAYTNAAWVIMGFNLVLVIWGEVLAKYISLSFAGTANL
FLIVGVFVCSSILNDAYFTARKNKKFLYVYAVIIAIQIFTVYQNWSQGSFGHDGHIYLTGEKAMSLLFILTFAVIFLVTA
YKTIQDKREGK

Nucleotide

• Length: 516 bp

>T152464 NZ_CP066174:c89654-89184 [Klebsiella quasipneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
TTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAACTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16998.26 Da
• Isoelectric Point: 9.5767

>AT152464 WP_002269854.1 NZ_CP050273:c1748914-1748468 [Streptococcus mutans]
MKMEKSNKQVIYDERQQQIQLKSYSLSFWFVMFILYFATFGKTDLLLNIAFWGGLVLNFCYSTLRGVGPFVDPRFGKIAK
IGRLAAVPLIFLGMLVFLVAIIMSILEHDSLRESITKCSYLGLSGFWLICMGASIVYRHYLDKKEADK

Nucleotide

• Length: 447 bp

>AT152464 NZ_CP066174:c90094-89651 [Klebsiella quasipneumoniae]
ATGAAAACATTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
CGTAGCGCTTCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGCGAATCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCGACCACGTTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTCATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAAGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAGACAGGAGCGTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA

Structures

Antitoxin

• AlphaFold DB: A0A829BWH5