Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 695752..696227 Replicon chromosome
Accession NZ_CP050273
Organism Streptococcus mutans strain P1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HB750_RS03525 Protein ID WP_002267440.1
Coordinates 695964..696227 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HB750_RS03520 Protein ID WP_002267439.1
Coordinates 695752..695967 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB750_RS03505 690820..691467 + 648 WP_049473636.1 hypothetical protein -
HB750_RS03510 691454..692527 + 1074 WP_049478662.1 hypothetical protein -
HB750_RS03515 692538..695555 + 3018 WP_049473697.1 type I restriction endonuclease subunit R -
HB750_RS03520 695752..695967 + 216 WP_002267439.1 hypothetical protein Antitoxin
HB750_RS03525 695964..696227 + 264 WP_002267440.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HB750_RS03530 696368..696532 + 165 WP_002267441.1 hypothetical protein -
HB750_RS03535 696638..696937 + 300 WP_002267442.1 STAS-like domain-containing protein -
HB750_RS03540 697037..697354 + 318 WP_002282430.1 helix-turn-helix domain-containing protein -
HB750_RS03545 697840..698484 - 645 WP_002278913.1 HAD family hydrolase -
HB750_RS03550 698573..698998 + 426 WP_019804813.1 GNAT family N-acetyltransferase -
HB750_RS03555 699009..700121 + 1113 WP_019804812.1 glycerate kinase -
HB750_RS03560 700198..700650 - 453 WP_019804811.1 YueI family protein -
HB750_RS03565 700799..701068 + 270 WP_002267448.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-69)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10291.86 Da        Isoelectric Point: 10.2942

>T152462 WP_002267440.1 NZ_CP050273:695964-696227 [Streptococcus mutans]
MSYKVIYTKKALKQLKKLDAFTRSSILLWIDKHLQGTHDPRQHGKGLTANRSGEWRYRVGDYRILANIFEDEIVIEVFSV
GHRRDIY

Download         Length: 264 bp

>T152462 NZ_CP066173:c4507892-4507611 [Klebsiella quasipneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGCTTGGCGAGACGGTCAAAAAACAGTTCAAAAA
TAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTGCCGGATTGCTACAAAATCAAGC
TTAAGGCGTCAGGTTATCGGCTGGTGTATCAAGTACGAGATAGGGTGGTGGTGGTTTACGTTATTGCCATTGGCAAAAGA
GAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 8364.43 Da        Isoelectric Point: 4.1348

>AT152462 WP_002267439.1 NZ_CP050273:695752-695967 [Streptococcus mutans]
MTTMTLRINDQDSDLIKNYIQMHGLTISEFARQAMLERIEDDYDLQVLRQAMAEDDGERISHEEIMKEFGL

Download         Length: 216 bp

>AT152462 NZ_CP066173:c4508124-4507882 [Klebsiella quasipneumoniae]
ATGGCCACGCTCAACGTTCGGCTGGATGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACGCC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGCGATG
GCGAAGCGGCGTTGTTACGCACCGTTCGCGAGCGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References