Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 603721..604307 Replicon chromosome
Accession NZ_CP050273
Organism Streptococcus mutans strain P1

Toxin (Protein)


Gene name hicA Uniprot ID A0A2J9QEE1
Locus tag HB750_RS03045 Protein ID WP_002264916.1
Coordinates 603721..603912 (+) Length 64 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0A8KA30
Locus tag HB750_RS03050 Protein ID WP_002265422.1
Coordinates 603930..604307 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB750_RS03030 601765..602631 + 867 WP_002269449.1 type II CRISPR-associated endonuclease Cas1 -
HB750_RS03035 602628..602972 + 345 WP_002272765.1 CRISPR-associated endonuclease Cas2 -
HB750_RS03040 602962..603624 + 663 WP_002263546.1 type II-A CRISPR-associated protein Csn2 -
HB750_RS03045 603721..603912 + 192 WP_002264916.1 type II toxin-antitoxin system HicA family toxin Toxin
HB750_RS03050 603930..604307 + 378 WP_002265422.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HB750_RS03055 604645..605538 - 894 WP_019804828.1 LexA family transcriptional regulator IrvR -
HB750_RS03060 605854..606138 + 285 WP_002278032.1 helix-turn-helix transcriptional regulator -
HB750_RS03065 606301..608052 + 1752 WP_167311816.1 LPXTG cell wall anchor domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-61)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(5-107)


Sequences

Toxin        


Download         Length: 64 a.a.        Molecular weight: 7149.51 Da        Isoelectric Point: 10.6223

>T152461 WP_002264916.1 NZ_CP050273:603721-603912 [Streptococcus mutans]
MPLTGKELAKLAINNGWEEVRVRGSHHHFKKDGVPYIVTIPIHGNKVLKIGLEKKLLRDLNLL

Download         Length: 192 bp

>T152461 NZ_CP066173:3785975-3786193 [Klebsiella quasipneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAACAAATATGAACTTTCTGATAATGAGCTGGCGGTATTTTACTCAGCCGCCGATCATCGTCTGGCTGAAC
TGACTATGAATAAGCTGTACGATAAAATCCCGACGTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14335.32 Da        Isoelectric Point: 4.5628

>AT152461 WP_002265422.1 NZ_CP050273:603930-604307 [Streptococcus mutans]
MLKTYPAIFHKEEEGYWVEFPEFGGGTQGEDLEEAMKNARQMLESVLASYLDEGMKLPNPSEIRKLSVEDGFATMIQADP
NPYLKNNKAIRKNVTVPEWLVQLADRDQVNYSEVLTKALERKLQL

Download         Length: 378 bp

>AT152461 NZ_CP066173:3785574-3785948 [Klebsiella quasipneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATCGCACAACTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACATCGGCTGTCAATCTCCAGTTAAATGAACTGATCGAGC
ACATTGCCACATTCGCCCTTAATTATAAAATTAAGTACGCTGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACATTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAATCGGTT
ATTTCGTTGTTTTGTCAACGCCAGCCGGGAAAATCCGGCCAGTCTTTCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J9QEE1

Antitoxin

Source ID Structure
AlphaFold DB A0A0A8KA30

References