Detailed information of TA system TA152460

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): SmuAT/-
• Location: 1474376..1475337
• Replicon: chromosome
• Accession: NZ_CP050272
• Organism: Streptococcus mutans strain P6

Toxin (Protein)

• Gene name: smuT
• Uniprot ID: -
• Locus tag: HB751_RS07225
• Protein ID: WP_019314493.1
• Coordinates: 1474822..1475337 (-)
• Length: 172 a.a.

Antitoxin (Protein)

• Gene name: smuA
• Uniprot ID: A0A829BWH5
• Locus tag: HB751_RS07220
• Protein ID: WP_002269854.1
• Coordinates: 1474376..1474822 (-)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HB751_RS07185	1469761..1470183	+	423	WP_018030837.1	hypothetical protein	-
HB751_RS07190	1470186..1471214	+	1029	WP_049473477.1	replication initiation factor domain-containing protein	-
HB751_RS07195	1471273..1471533	+	261	WP_002279804.1	helix-turn-helix domain-containing protein	-
HB751_RS07200	1471602..1472819	+	1218	WP_049473478.1	tyrosine-type recombinase/integrase	-
HB751_RS07205	1472929..1473321	-	393	WP_002262992.1	30S ribosomal protein S9	-
HB751_RS07210	1473346..1473792	-	447	WP_002262993.1	50S ribosomal protein L13	-
HB751_RS07215	1474185..1474379	-	195	WP_002262994.1	helix-turn-helix transcriptional regulator	-
HB751_RS07220	1474376..1474822	-	447	WP_002269854.1	hypothetical protein	Antitoxin
HB751_RS07225	1474822..1475337	-	516	WP_019314493.1	hypothetical protein	Toxin
HB751_RS07230	1475469..1476329	-	861	WP_002265709.1	DegV family protein	-
HB751_RS07235	1476353..1477099	-	747	WP_002264862.1	23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB	-
HB751_RS07240	1477412..1477966	+	555	WP_002262999.1	PadR family transcriptional regulator	-
HB751_RS07245	1478155..1479147	+	993	WP_019804634.1	BtrH N-terminal domain-containing protein	-
HB751_RS07250	1479183..1479920	-	738	WP_002272256.1	MerR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1448415..1484598	36183

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (5-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 172 a.a.
• Molecular weight: 19526.18 Da
• Isoelectric Point: 9.8653

>T152460 WP_019314493.1 NZ_CP050272:c1475337-1474822 [Streptococcus mutans]
MFDLVVNLILLVIVIGGFVFLRFYADKKGKREYDERQLLMQKKAYTNAAWVIMGFNLVLVIWGEVLAKYISLSFAGTANL
FLIVGVFVCSSILNDAYFTARKNKKFLYVYAVIIAIQIFTVYQNWSQGSFGHDGHIYLTGEKAMSLLFILTFAVIFLVTA
YKTIQDKREGK

Nucleotide

• Length: 516 bp

>T152460 NZ_CP066173:c2484204-2482882 [Klebsiella quasipneumoniae]
ATGGCGACGCTCACCACCTGGATGAACAATGCGCGCGTGGGAACCTTAACCCGCCAGGCCAACGGGGCGCACAGTTTCCG
CTATGATGAGGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCGCTGCCGCTGCAGTATGGCAATATCACCG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGAGCGGATCGTCAGGCGCTATCAG
GCGCGTTCGAAACAGCCGTTCGATCTGCTGGCCGAGGTCGGGCGGGACAGCGTAGGGGCGGTGACTCTGCTGCCGCCGGG
GGAAGAGGCGCATCTTGCCGCGTTGCGCTGGCAGACGCTGGATGAGGCGCAGCTGACCGCTTTGCTGACCGCCTACCAGT
CGGATATTCCTCTCGGAATGGTGACCGGCCAGGACGATTTTCGTATCTCGGTGGCCGGCGCTCAGGAGAAAACCGCGCTG
CTGCGAATGGGCGAGCACTGGTGTATTCCGCAGGGCACCACCCCGACCACCCATATCATTAAACTGCCCATCGGCGAGAT
AAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAACGAATATCTGTGCCTGGCGCTGGCCAGGGCGTTGG
GCCTGGCGGTGCCGGAGGCGGAGATTATCAACACGCCGCGGATCCGTGCGCTGGCGGTGACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGGCGCGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCATTCGGCATACCGTCGTCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGTTCCAGTGAGGCCCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTGTTCCAGTGGCTGACCGGGGCTACGGACGGGCATGCGAAGAACTTCTCGCTCTTTTTGCTG
CCCGGCGGCAGCTACCGGCTCACGCCGTTCTACGACATTATTTCGGCATTTCCGGTGCTGGGCGGGACGGGACTGCATCT
GCGCGACCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGGAAAACGGAGATTAACGCTATCTATCCGCGTCATT
TTCTGGCGACCGCCAAAGCGGTTAACTTCCCCCGGGAGCAGATGCTGGCGATCCTGGGCGAGTTTGCCGACCGCGTGCCG
CAGGCCATCGAAAGCGCCCGCCAAACGCTGCCGTCGGACTTTTCCGCCCACGTCTGGCGGGCCATCACGGAGAACATGCT
TAAACTGCACGCCCGCCTGCAGCAAGGGCTGCTGGCGGGATAG

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16998.26 Da
• Isoelectric Point: 9.5767

>AT152460 WP_002269854.1 NZ_CP050272:c1474822-1474376 [Streptococcus mutans]
MKMEKSNKQVIYDERQQQIQLKSYSLSFWFVMFILYFATFGKTDLLLNIAFWGGLVLNFCYSTLRGVGPFVDPRFGKIAK
IGRLAAVPLIFLGMLVFLVAIIMSILEHDSLRESITKCSYLGLSGFWLICMGASIVYRHYLDKKEADK

Nucleotide

• Length: 447 bp

>AT152460 NZ_CP066173:c2484470-2484204 [Klebsiella quasipneumoniae]
ATGAATTCCCCGCAGATATACAGTCCGGTTCAGCTGGCCAATTACCTGAAACTGCTGCGCCAGCAAAATCACTGGACTCA
GGAGGCGCTGGCCAGCCGGATCGGCATTAAACAGGCGACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACCCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACCCTGAACGCCAAACCGGCAGAGACGGCGATGATTCCC
GATAACACCACGGATCTTGACTGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A829BWH5