Detailed information of TA system TA152456

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): SmuAT/-
• Location: 1743806..1744767
• Replicon: chromosome
• Accession: NZ_CP050271
• Organism: Streptococcus mutans strain S1

Toxin (Protein)

• Gene name: smuT
• Uniprot ID: -
• Locus tag: HB752_RS08585
• Protein ID: WP_019314493.1
• Coordinates: 1744252..1744767 (-)
• Length: 172 a.a.

Antitoxin (Protein)

• Gene name: smuA
• Uniprot ID: A0A829BWH5
• Locus tag: HB752_RS08580
• Protein ID: WP_002269854.1
• Coordinates: 1743806..1744252 (-)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HB752_RS08545	1739191..1739613	+	423	WP_018030837.1	hypothetical protein	-
HB752_RS08550	1739616..1740644	+	1029	WP_049473477.1	replication initiation factor domain-containing protein	-
HB752_RS08555	1740703..1740963	+	261	WP_002279804.1	helix-turn-helix domain-containing protein	-
HB752_RS08560	1741032..1742249	+	1218	WP_049473478.1	tyrosine-type recombinase/integrase	-
HB752_RS08565	1742359..1742751	-	393	WP_002262992.1	30S ribosomal protein S9	-
HB752_RS08570	1742776..1743222	-	447	WP_002262993.1	50S ribosomal protein L13	-
HB752_RS08575	1743615..1743809	-	195	WP_002262994.1	helix-turn-helix transcriptional regulator	-
HB752_RS08580	1743806..1744252	-	447	WP_002269854.1	hypothetical protein	Antitoxin
HB752_RS08585	1744252..1744767	-	516	WP_019314493.1	hypothetical protein	Toxin
HB752_RS08590	1744899..1745759	-	861	WP_002265709.1	DegV family protein	-
HB752_RS08595	1745783..1746529	-	747	WP_002264862.1	23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB	-
HB752_RS08600	1746842..1747396	+	555	WP_002262999.1	PadR family transcriptional regulator	-
HB752_RS08605	1747585..1748577	+	993	WP_019804634.1	BtrH N-terminal domain-containing protein	-
HB752_RS08610	1748613..1749350	-	738	WP_002272256.1	MerR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1717845..1754028	36183

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-75)

Sequences

Toxin

Protein

• Length: 172 a.a.
• Molecular weight: 19526.18 Da
• Isoelectric Point: 9.8653

>T152456 WP_019314493.1 NZ_CP050271:c1744767-1744252 [Streptococcus mutans]
MFDLVVNLILLVIVIGGFVFLRFYADKKGKREYDERQLLMQKKAYTNAAWVIMGFNLVLVIWGEVLAKYISLSFAGTANL
FLIVGVFVCSSILNDAYFTARKNKKFLYVYAVIIAIQIFTVYQNWSQGSFGHDGHIYLTGEKAMSLLFILTFAVIFLVTA
YKTIQDKREGK

Nucleotide

• Length: 516 bp

>T152456 NZ_CP066172:c1292957-1292703 [Streptococcus oralis]
ATGCTGCTCAAGTTTACAGAAGATGCCTGGGCAGATTATTGTTACTGGCAAACTCAGGACAAGAAAACGCTAAAAAGAAT
CAATAAACTAATCAAGGATATTCAACGCGATCCTTTTTCAGGAATTGGTAAACCAGAACCACTCAAGTATGACTACCAAG
GAGCTTGGTCACGTCGTATTGATGCAGAAAATCGCTTGATTTATATGATGGATGGAGATAGCATCGCTTTCTTGTCCTTC
AAAGATCACTACTAA

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16998.26 Da
• Isoelectric Point: 9.5767

>AT152456 WP_002269854.1 NZ_CP050271:c1744252-1743806 [Streptococcus mutans]
MKMEKSNKQVIYDERQQQIQLKSYSLSFWFVMFILYFATFGKTDLLLNIAFWGGLVLNFCYSTLRGVGPFVDPRFGKIAK
IGRLAAVPLIFLGMLVFLVAIIMSILEHDSLRESITKCSYLGLSGFWLICMGASIVYRHYLDKKEADK

Nucleotide

• Length: 447 bp

>AT152456 NZ_CP066172:c1293215-1292961 [Streptococcus oralis]
ATGGAAGCAGTTCTTTATTCAACATTCCGAAATCATTTAAAAGACTACATGAAGAAGGTAAACGATGAATTTGAGCCTTT
GACGGTGGTCAATAAAAATCCTGATGAGGATATTGTTGTCCTTTCAAAGAGCGAGTGGGATAGTATTCAAGAAACCCTAA
GAATCGCTCAAAACAAGGAACTTTCTGATAAGGTTTTGCGAGGAATGGCTCAAGTCCGAGCTGGAAGTACTCAGGCCCAT
GTTATTGAGGAGTGA

Structures

Antitoxin

• AlphaFold DB: A0A829BWH5