Detailed information of TA system TA152452

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): SmuAT/-
• Location: 1748467..1749428
• Replicon: chromosome
• Accession: NZ_CP050270
• Organism: Streptococcus mutans strain S4

Toxin (Protein)

• Gene name: smuT
• Uniprot ID: -
• Locus tag: HB753_RS08610
• Protein ID: WP_019314493.1
• Coordinates: 1748913..1749428 (-)
• Length: 172 a.a.

Antitoxin (Protein)

• Gene name: smuA
• Uniprot ID: A0A829BWH5
• Locus tag: HB753_RS08605
• Protein ID: WP_002269854.1
• Coordinates: 1748467..1748913 (-)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HB753_RS08570	1743852..1744274	+	423	WP_018030837.1	hypothetical protein	-
HB753_RS08575	1744277..1745305	+	1029	WP_049473477.1	replication initiation factor domain-containing protein	-
HB753_RS08580	1745364..1745624	+	261	WP_002279804.1	helix-turn-helix domain-containing protein	-
HB753_RS08585	1745693..1746910	+	1218	WP_049473478.1	tyrosine-type recombinase/integrase	-
HB753_RS08590	1747020..1747412	-	393	WP_002262992.1	30S ribosomal protein S9	-
HB753_RS08595	1747437..1747883	-	447	WP_002262993.1	50S ribosomal protein L13	-
HB753_RS08600	1748276..1748470	-	195	WP_002262994.1	helix-turn-helix transcriptional regulator	-
HB753_RS08605	1748467..1748913	-	447	WP_002269854.1	hypothetical protein	Antitoxin
HB753_RS08610	1748913..1749428	-	516	WP_019314493.1	hypothetical protein	Toxin
HB753_RS08615	1749560..1750420	-	861	WP_002265709.1	DegV family protein	-
HB753_RS08620	1750444..1751190	-	747	WP_002264862.1	23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB	-
HB753_RS08625	1751503..1752057	+	555	WP_002262999.1	PadR family transcriptional regulator	-
HB753_RS08630	1752246..1753238	+	993	WP_019804634.1	BtrH N-terminal domain-containing protein	-
HB753_RS08635	1753274..1754011	-	738	WP_002272256.1	MerR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1722506..1758689	36183

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (4-111)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 172 a.a.
• Molecular weight: 19526.18 Da
• Isoelectric Point: 9.8653

>T152452 WP_019314493.1 NZ_CP050270:c1749428-1748913 [Streptococcus mutans]
MFDLVVNLILLVIVIGGFVFLRFYADKKGKREYDERQLLMQKKAYTNAAWVIMGFNLVLVIWGEVLAKYISLSFAGTANL
FLIVGVFVCSSILNDAYFTARKNKKFLYVYAVIIAIQIFTVYQNWSQGSFGHDGHIYLTGEKAMSLLFILTFAVIFLVTA
YKTIQDKREGK

Nucleotide

• Length: 516 bp

>T152452 NZ_CP066168:241541-241891 [Bacillus anthracis]
TTGATTGTAAAACGCGGCGACGTGTATTTTGCAGACCTTTCCCCAGTTGTTGGTTCTGAGCAAGGAGGTGTTCGTCCGGT
TCTTGTCATTCAAAATGACATCGGAAATCGTTTTAGTCCAACGGTGATTGTAGCGGCTATTACTGCACAGATTCAAAAAG
CGAAATTACCCACTCATGTGGAAATTGATGCGAAAAAGTACGGTTTTGAGAGAGATTCTGTTATTTTACTTGAGCAGATT
CGAACAATCGATAAGCAGCGCTTAACGGACAAAATCACTCACTTAGATGAAGTGATGATGATTCGTGTAGATGAAGCGCT
ACAAATTAGTTTAGGACTAATAGATTTTTAA

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16998.26 Da
• Isoelectric Point: 9.5767

>AT152452 WP_002269854.1 NZ_CP050270:c1748913-1748467 [Streptococcus mutans]
MKMEKSNKQVIYDERQQQIQLKSYSLSFWFVMFILYFATFGKTDLLLNIAFWGGLVLNFCYSTLRGVGPFVDPRFGKIAK
IGRLAAVPLIFLGMLVFLVAIIMSILEHDSLRESITKCSYLGLSGFWLICMGASIVYRHYLDKKEADK

Nucleotide

• Length: 447 bp

>AT152452 NZ_CP066168:241249-241536 [Bacillus anthracis]
GTGTCCGAATCAAGTGTAACTACTGAAATCGTGGTTCGGTTGCCAAAGCAAATGGTAACGGAATTGGACGGAATTGGAAA
ACAAGAGAATAAGAATCGCCATGAACTAATTTGCCAGGCAACACAACTGTTATTGCGTCAACATAAGACGAAGAAACGCT
ACCAACATGAATCAATGCGACGTGGGTACATTGAAATGGGAAAAATTAATCTTGGTATTGCATCTGAAGCTTTCTTAGCA
GAGTATGAAGCAGCTCATACAGTAGAACGCTTAGTTAGCGGGGGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A829BWH5