Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 695749..696224 Replicon chromosome
Accession NZ_CP050270
Organism Streptococcus mutans strain S4

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HB753_RS03525 Protein ID WP_002267440.1
Coordinates 695961..696224 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HB753_RS03520 Protein ID WP_002267439.1
Coordinates 695749..695964 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB753_RS03505 690817..691464 + 648 WP_049473636.1 hypothetical protein -
HB753_RS03510 691451..692524 + 1074 WP_049478662.1 hypothetical protein -
HB753_RS03515 692535..695552 + 3018 WP_049473697.1 type I restriction endonuclease subunit R -
HB753_RS03520 695749..695964 + 216 WP_002267439.1 hypothetical protein Antitoxin
HB753_RS03525 695961..696224 + 264 WP_002267440.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HB753_RS03530 696365..696529 + 165 WP_002267441.1 hypothetical protein -
HB753_RS03535 696635..696934 + 300 WP_002267442.1 STAS-like domain-containing protein -
HB753_RS03540 697034..697351 + 318 WP_002282430.1 helix-turn-helix domain-containing protein -
HB753_RS03545 697837..698481 - 645 WP_002278913.1 HAD family hydrolase -
HB753_RS03550 698570..698995 + 426 WP_019804813.1 GNAT family N-acetyltransferase -
HB753_RS03555 699006..700118 + 1113 WP_019804812.1 glycerate kinase -
HB753_RS03560 700195..700647 - 453 WP_019804811.1 YueI family protein -
HB753_RS03565 700796..701065 + 270 WP_002267448.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-69)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10291.86 Da        Isoelectric Point: 10.2942

>T152450 WP_002267440.1 NZ_CP050270:695961-696224 [Streptococcus mutans]
MSYKVIYTKKALKQLKKLDAFTRSSILLWIDKHLQGTHDPRQHGKGLTANRSGEWRYRVGDYRILANIFEDEIVIEVFSV
GHRRDIY

Download         Length: 264 bp

>T152450 NZ_CP066167:3991662-3991922 [Spongiibacter sp. CSC3.9]
ATGCGCCCATTTCTGCTCACCGCCGTTGCCCGAAAAGACATTATTGATATTGGCCGTTATACCACTGAGAAGTGGGGAAA
GCGGCAACGCGATAAATACCTCAAGCAGCTTGATGATGCCTTCAAGATGCTTGCTCGCCAACCTGAAATAGGCCGCGATG
CGGATGACGTAAAGCCTGGATACAAAAAGTTCAGTCAAAAGCCGCAACGAAAAAGCCGTCGCTGTGCCTGCGATTGTTAT
GCTGGACCAAGATCACATTAA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 8364.43 Da        Isoelectric Point: 4.1348

>AT152450 WP_002267439.1 NZ_CP050270:695749-695964 [Streptococcus mutans]
MTTMTLRINDQDSDLIKNYIQMHGLTISEFARQAMLERIEDDYDLQVLRQAMAEDDGERISHEEIMKEFGL

Download         Length: 216 bp

>AT152450 NZ_CP066167:3991423-3991662 [Spongiibacter sp. CSC3.9]
ATGGCTAGAAATACCAGCATTACCCTTGGTCCCCACTTTGATGAGTTTATAGCCGCACAGGTTAAAAATGGCCGCTATGG
TTCCGTTAGCGAAGTGGTTCGTGCCGGGCTGCGTCTGCTTGAAGAAACTGAGAGTAAGCTTGACCGGCTCCGACGCCTTC
TGGATGAAGGCGAGCAAAGCGGAATAGCGGACTACTCTCTCGAAAGTGTTATTGCAGAACTGGATAATGAAGCTCACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References