Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 603717..604303 Replicon chromosome
Accession NZ_CP050270
Organism Streptococcus mutans strain S4

Toxin (Protein)


Gene name hicA Uniprot ID A0A2J9QEE1
Locus tag HB753_RS03045 Protein ID WP_002264916.1
Coordinates 603717..603908 (+) Length 64 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0A8KA30
Locus tag HB753_RS03050 Protein ID WP_002265422.1
Coordinates 603926..604303 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB753_RS03030 601761..602627 + 867 WP_002269449.1 type II CRISPR-associated endonuclease Cas1 -
HB753_RS03035 602624..602968 + 345 WP_002272765.1 CRISPR-associated endonuclease Cas2 -
HB753_RS03040 602958..603620 + 663 WP_002263546.1 type II-A CRISPR-associated protein Csn2 -
HB753_RS03045 603717..603908 + 192 WP_002264916.1 type II toxin-antitoxin system HicA family toxin Toxin
HB753_RS03050 603926..604303 + 378 WP_002265422.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HB753_RS03055 604641..605534 - 894 WP_019804828.1 LexA family transcriptional regulator IrvR -
HB753_RS03060 605850..606134 + 285 WP_002278032.1 helix-turn-helix transcriptional regulator -
HB753_RS03065 606297..608048 + 1752 WP_167311816.1 LPXTG cell wall anchor domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-61)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(5-107)


Sequences

Toxin        


Download         Length: 64 a.a.        Molecular weight: 7149.51 Da        Isoelectric Point: 10.6223

>T152449 WP_002264916.1 NZ_CP050270:603717-603908 [Streptococcus mutans]
MPLTGKELAKLAINNGWEEVRVRGSHHHFKKDGVPYIVTIPIHGNKVLKIGLEKKLLRDLNLL

Download         Length: 192 bp

>T152449 NZ_CP066167:1344805-1345080 [Spongiibacter sp. CSC3.9]
ATGGAATCAGCGAAGATTGAAATTCTCTCATGGACGAGAGAGGCCTGGTCGGACTACCTCTACTGGCAATCGCAAGATAA
GAAAACGCTAAAGCGCATCAACAAGCTGATACGAGATACCCAGCGTTCACCGTTTGAGGGGATAGGCAAGCCAGAGCCCC
TGAAAGAAAGCTTGACCGGTTTTTGGTCAAGACGAATCGACGATACCCACCGTTTGGTATACGCGGTAGATAGCGATCAA
GTCACAATCATTGCATGCCGATACCACTACACGTAG

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14335.32 Da        Isoelectric Point: 4.5628

>AT152449 WP_002265422.1 NZ_CP050270:603926-604303 [Streptococcus mutans]
MLKTYPAIFHKEEEGYWVEFPEFGGGTQGEDLEEAMKNARQMLESVLASYLDEGMKLPNPSEIRKLSVEDGFATMIQADP
NPYLKNNKAIRKNVTVPEWLVQLADRDQVNYSEVLTKALERKLQL

Download         Length: 378 bp

>AT152449 NZ_CP066167:1344570-1344824 [Spongiibacter sp. CSC3.9]
ATGAAGGTCATAAGCTTTTCGGATGCCCGAAACAAACTCAAAAGCGTGTTGGATCAGGTGGTTAACGACGCTGACTACAC
TATTATCAGTCGTCGGGGTGGCGAGGACGCGGTTGTGATGTCTTTAGACCAATTCAATGGTCTCATGGAAACCGTGCACC
TACTGAAAAGCCCCGCAAACGCGGCACACCTATCAAAATCCATACAGCAATATCGCGCAGGCAAAACAAAGCAGCATGGA
ATCAGCGAAGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J9QEE1

Antitoxin

Source ID Structure
AlphaFold DB A0A0A8KA30

References