Detailed information of TA system TA152448

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 217615..218174
• Replicon: chromosome
• Accession: NZ_CP050267
• Organism: Salinivibrio costicola strain M318

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HBA18_RS14450
• Protein ID: WP_167315175.1
• Coordinates: 217896..218174 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1N6J1W2
• Locus tag: HBA18_RS14445
• Protein ID: WP_069586513.1
• Coordinates: 217615..217896 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HBA18_RS14420	212735..213196	-	462	WP_167315172.1	hypothetical protein	-
HBA18_RS14425	213285..213800	-	516	WP_167315173.1	GNAT family N-acetyltransferase	-
HBA18_RS14430	213900..214136	-	237	WP_077457223.1	hypothetical protein	-
HBA18_RS14435	214452..215615	-	1164	WP_069589270.1	cytotoxin	-
HBA18_RS14440	216324..217145	-	822	WP_167315174.1	NAD(P)-dependent oxidoreductase	-
HBA18_RS14445	217615..217896	+	282	WP_069586513.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HBA18_RS14450	217896..218174	+	279	WP_167315175.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HBA18_RS14455	218342..218830	-	489	WP_167315176.1	GNAT family N-acetyltransferase	-
HBA18_RS14460	218960..219496	-	537	WP_167315177.1	hypothetical protein	-
HBA18_RS14465	220400..220903	-	504	WP_167315178.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	211445..220903	9458

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-69)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10804.54 Da
• Isoelectric Point: 4.4290

>T152448 WP_167315175.1 NZ_CP050267:217896-218174 [Salinivibrio costicola]
MILWEEASLNDREKIFEFLYDFNPEVAEKTDSLIEAKVENLLEQPLMGLQRDGIRGRLLIIPEISMIVSYRVEGDIIQVM
RVLHQKQKFPTD

Nucleotide

• Length: 279 bp

>T152448 NZ_CP066167:1344570-1344824 [Spongiibacter sp. CSC3.9]
ATGAAGGTCATAAGCTTTTCGGATGCCCGAAACAAACTCAAAAGCGTGTTGGATCAGGTGGTTAACGACGCTGACTACAC
TATTATCAGTCGTCGGGGTGGCGAGGACGCGGTTGTGATGTCTTTAGACCAATTCAATGGTCTCATGGAAACCGTGCACC
TACTGAAAAGCCCCGCAAACGCGGCACACCTATCAAAATCCATACAGCAATATCGCGCAGGCAAAACAAAGCAGCATGGA
ATCAGCGAAGATTGA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10911.20 Da
• Isoelectric Point: 8.0533

>AT152448 WP_069586513.1 NZ_CP050267:217615-217896 [Salinivibrio costicola]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQAAQSR
MEERKARIRNRGK

Nucleotide

• Length: 282 bp

>AT152448 NZ_CP066167:1344805-1345080 [Spongiibacter sp. CSC3.9]
ATGGAATCAGCGAAGATTGAAATTCTCTCATGGACGAGAGAGGCCTGGTCGGACTACCTCTACTGGCAATCGCAAGATAA
GAAAACGCTAAAGCGCATCAACAAGCTGATACGAGATACCCAGCGTTCACCGTTTGAGGGGATAGGCAAGCCAGAGCCCC
TGAAAGAAAGCTTGACCGGTTTTTGGTCAAGACGAATCGACGATACCCACCGTTTGGTATACGCGGTAGATAGCGATCAA
GTCACAATCATTGCATGCCGATACCACTACACGTAG

Structures

Antitoxin

• AlphaFold DB: A0A1N6J1W2