Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 201333..201984 Replicon chromosome
Accession NZ_CP050267
Organism Salinivibrio costicola strain M318

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag HBA18_RS14355 Protein ID WP_167315412.1
Coordinates 201580..201984 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A1V3HTW4
Locus tag HBA18_RS14350 Protein ID WP_069363032.1
Coordinates 201333..201566 (+) Length 78 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HBA18_RS14330 196822..199269 + 2448 WP_167315162.1 DUF2309 domain-containing protein -
HBA18_RS14335 199278..200249 + 972 WP_139130769.1 threonylcarbamoyl-AMP synthase -
HBA18_RS14340 200242..200661 - 420 WP_167315163.1 PaaI family thioesterase -
HBA18_RS14345 200654..201163 - 510 WP_167315164.1 hypothetical protein -
HBA18_RS14350 201333..201566 + 234 WP_069363032.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HBA18_RS14355 201580..201984 + 405 WP_167315412.1 type II toxin-antitoxin system VapC family toxin Toxin
HBA18_RS14360 202016..202297 - 282 WP_021023566.1 DUF134 domain-containing protein -
HBA18_RS14365 202425..203873 - 1449 WP_167315165.1 decarboxylating NADP(+)-dependent phosphogluconate dehydrogenase -
HBA18_RS14370 203885..204610 - 726 WP_167315166.1 6-phosphogluconolactonase -
HBA18_RS14375 204607..206109 - 1503 WP_077662404.1 glucose-6-phosphate dehydrogenase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-126)

Antitoxin

(7-53)


Sequences


Toxin        


Download         Length: 135 a.a.        Molecular weight: 14728.17 Da        Isoelectric Point: 9.2145

>T152447 WP_167315412.1 NZ_CP050267:201580-201984 [Salinivibrio costicola]
MLDTCICSFIMREQPKAVLKKLHTVVGNQHRIVISAITYQEMQYGLLGKKASPKHAVLVDAFLQRIDEILPWDKAAVDAT
TAVKRNLMNKGKGTPIGGNDTAIAGHAIATGCVLVTNNTREFQRVEGLKLEDWA

Download         Length: 405 bp

>T152447 NZ_CP066167:c736672-736421 [Spongiibacter sp. CSC3.9]
ATGGACAGTATAAGCTATACCGCCGCCAGGAGCAACTTGGCGAAAACTATGGAGCAGGTCTGTAACGACCATGCGCCCAT
TGCTATTACCCGCAAGGGCGAAGGTGCCGTTGTGATGATTTCTATGGACGACTACCAAGCCTTGGAAGAAACGGCATATC
TGCTTCGGAGCCCCAAAAATACCCGACGCCTGATCGAGTCTATTGCCGAGCTTGAGGACGGCAAAGGCCAAGAAAAGGAA
TTGATTGAGTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 9013.13 Da        Isoelectric Point: 4.8668

>AT152447 WP_069363032.1 NZ_CP050267:201333-201566 [Salinivibrio costicola]
MRTISIFKNGKNQAVRLPKDFEFDGVNELEIHKEGDVITLRPARPSWLSFGELEKADSDFMTHREELIKDEGRFNFD

Download         Length: 234 bp

>AT152447 NZ_CP066167:c736424-736170 [Spongiibacter sp. CSC3.9]
GTGAAGTTAATTTTTGCAGAGAAGGCATGGGAGGATTACCTGTACTGGCAAAAAACGGACAAACAGACACTGAAACGTAT
TAATACCCTTATCAAGGAAATCAAACGAGAACCATTCGAAGGCATTGGAAAGCCAGAGCCGCTCAAACATGCCCTTTCGG
GGTATTGGTCTCGAAGGATTAACGATGAGCACCGAATGGTTTATAAAATTCATCAAGATTCCCTGCTTATTGCCCAACTT
CGCTACCACTACTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A1V3HTW4

References