Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3046487..3047153 Replicon chromosome
Accession NZ_CP050258
Organism Erwinia amylovora strain FB-86

Toxin (Protein)


Gene name cptA Uniprot ID A0A830ZTB8
Locus tag EHW96_RS13780 Protein ID WP_004161808.1
Coordinates 3046487..3046906 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID D4HWC2
Locus tag EHW96_RS13785 Protein ID WP_004155593.1
Coordinates 3046887..3047153 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EHW96_RS13765 3042479..3044158 + 1680 WP_004155599.1 type III effector -
EHW96_RS13770 3044668..3045621 + 954 WP_004155597.1 DMT family transporter -
EHW96_RS13775 3045851..3046369 + 519 WP_004155596.1 flavodoxin FldB -
EHW96_RS13780 3046487..3046906 - 420 WP_004161808.1 hypothetical protein Toxin
EHW96_RS13785 3046887..3047153 - 267 WP_004155593.1 FAD assembly factor SdhE Antitoxin
EHW96_RS13790 3047379..3048365 + 987 WP_004155590.1 tRNA-modifying protein YgfZ -
EHW96_RS13795 3048366..3049025 - 660 WP_004155588.1 hemolysin III family protein -
EHW96_RS13800 3049238..3049846 + 609 WP_004155587.1 HD domain-containing protein -
EHW96_RS13805 3049951..3050643 - 693 WP_004155586.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(8-79)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 16366.46 Da        Isoelectric Point: 11.9444

>T152432 WP_004161808.1 NZ_CP050258:c3046906-3046487 [Erwinia amylovora]
VVLWQCELRPSRLAQRFSLLLHGAVMLALLLPTWPASSGLVRMLLLVLVLLECIRSRRRIGRRQGDIALLEGHELRWRQR
EWCIISRPWLTGQAILLLLQDTHGQRERLWLFADGMEKRNWRQLRLQLLNSKVQGNGWC

Download         Length: 420 bp

>T152432 NZ_CP066151:2016996-2017098 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10498.07 Da        Isoelectric Point: 6.4605

>AT152432 WP_004155593.1 NZ_CP050258:c3047153-3046887 [Erwinia amylovora]
MDITNKSRIHWACRRGMRELDISIMPFFQYEFDSLNDSDKRLFVRLLESDDPDLFNWLMNHGEPADVELKRMVALIQQRN
KQRGPVAM

Download         Length: 267 bp

>AT152432 NZ_CP066151:c2017105-2016960 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A830ZTB8

Antitoxin

Source ID Structure
AlphaFold DB A0A831A3F0

References