Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1139959..1140452 Replicon chromosome
Accession NZ_CP050255
Organism Enterococcus faecium strain DT1-1

Toxin (Protein)


Gene name relE Uniprot ID A0A829A9S0
Locus tag F0186_RS05545 Protein ID WP_002342567.1
Coordinates 1140186..1140452 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A829AAJ0
Locus tag F0186_RS05540 Protein ID WP_002329324.1
Coordinates 1139959..1140189 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F0186_RS05515 1135430..1135756 + 327 Protein_1089 hypothetical protein -
F0186_RS05520 1135831..1136993 + 1163 WP_087628202.1 IS3 family transposase -
F0186_RS05525 1137452..1138042 - 591 WP_002342564.1 glutamine amidotransferase -
F0186_RS05530 1138830..1139135 + 306 WP_002342565.1 hypothetical protein -
F0186_RS05535 1139148..1139483 + 336 WP_002329326.1 hypothetical protein -
F0186_RS05540 1139959..1140189 + 231 WP_002329324.1 hypothetical protein Antitoxin
F0186_RS05545 1140186..1140452 + 267 WP_002342567.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F0186_RS05550 1140704..1140931 + 228 WP_002329322.1 hypothetical protein -
F0186_RS05555 1140947..1142113 + 1167 WP_002329321.1 oxygen-independent coproporphyrinogen III oxidase -
F0186_RS05560 1142346..1143389 + 1044 WP_073441383.1 heat-inducible transcriptional repressor HrcA -
F0186_RS05565 1143483..1144046 + 564 WP_002292135.1 nucleotide exchange factor GrpE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10651.28 Da        Isoelectric Point: 10.1925

>T152424 WP_002342567.1 NZ_CP050255:1140186-1140452 [Enterococcus faecium]
MTYRLEFTPEIQKQLRKMDKHQATLIVRWLYQHIDGIDDPRKFGKGFTANRSGQWRYRIGKYRVLVEIEDDQMVVIAIQV
GHRRNIYD

Download         Length: 267 bp

>T152424 NZ_CP066149:2062900-2063154 [Vibrio sp. ED004]
ATGAGAATCGTATCTTTTACTGAAGCTAGAAATGGTCTCAAAGCTGTTTTGGACGGTGTTGTTAATGATGCTGATACAAC
AGTCATTACACGTCGTGATTCTGAAGATGCTGTGGTTATGTCTTTAGATTACTACAACAGCTTAATGGAGACCGTTCACT
TACTTCGTTCACCTCAAAACGTTGAACATTTAAATCGCTCCATAGCACAGTATCGTGCTGGAAAAACAACAGCCCGAGAG
CTGATTGATGAGTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8863.97 Da        Isoelectric Point: 4.1938

>AT152424 WP_002329324.1 NZ_CP050255:1139959-1140189 [Enterococcus faecium]
MAMITVRVSDAEKEWLSYMAEFYGITLSELLKTYSMEQLEDEYDRQTAEIAHKHWVESGKTTVSMEEILHEFGGLE

Download         Length: 231 bp

>AT152424 NZ_CP066149:2063147-2063416 [Vibrio sp. ED004]
ATGAGTAGTCGTCAACGTTTACTATCGTGGACAGATGACGCTTGGGACGACTACTTGTATTGGCAGACTCAAGACAAGAA
GACGTTAAAGCGTGTCAACAAACTTATTAATGATGTGAAGCGTTCTTCATTTGATGGCATTGGTAAGCCAGAGCCGTTAA
AAGAGAATTTGTCTGGGTTTTGGTCTCGTCGCATTGACGATACCAATAGGCTTGTCTACGCAGTCGATGATCAAGCGATA
ACGATAATTTCGTGTCGTTACCACTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829A9S0

Antitoxin

Source ID Structure
AlphaFold DB A0A829AAJ0

References