Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | cptAB/Cpta(toxin) |
Location | 3046014..3046680 | Replicon | chromosome |
Accession | NZ_CP050240 | ||
Organism | Erwinia amylovora strain FB-20 |
Toxin (Protein)
Gene name | cptA | Uniprot ID | A0A830ZTB8 |
Locus tag | EGZ89_RS13785 | Protein ID | WP_004161808.1 |
Coordinates | 3046014..3046433 (-) | Length | 140 a.a. |
Antitoxin (Protein)
Gene name | cptB | Uniprot ID | D4HWC2 |
Locus tag | EGZ89_RS13790 | Protein ID | WP_004155593.1 |
Coordinates | 3046414..3046680 (-) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
EGZ89_RS13770 | 3042006..3043685 | + | 1680 | WP_004155599.1 | type III effector | - |
EGZ89_RS13775 | 3044195..3045148 | + | 954 | WP_004155597.1 | DMT family transporter | - |
EGZ89_RS13780 | 3045378..3045896 | + | 519 | WP_004155596.1 | flavodoxin FldB | - |
EGZ89_RS13785 | 3046014..3046433 | - | 420 | WP_004161808.1 | hypothetical protein | Toxin |
EGZ89_RS13790 | 3046414..3046680 | - | 267 | WP_004155593.1 | FAD assembly factor SdhE | Antitoxin |
EGZ89_RS13795 | 3046906..3047892 | + | 987 | WP_004155590.1 | tRNA-modifying protein YgfZ | - |
EGZ89_RS13800 | 3047893..3048552 | - | 660 | WP_004155588.1 | hemolysin III family protein | - |
EGZ89_RS13805 | 3048765..3049373 | + | 609 | WP_004155587.1 | HD domain-containing protein | - |
EGZ89_RS13810 | 3049478..3050170 | - | 693 | WP_004155586.1 | SDR family oxidoreductase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 140 a.a. Molecular weight: 16366.46 Da Isoelectric Point: 11.9444
>T152397 WP_004161808.1 NZ_CP050240:c3046433-3046014 [Erwinia amylovora]
VVLWQCELRPSRLAQRFSLLLHGAVMLALLLPTWPASSGLVRMLLLVLVLLECIRSRRRIGRRQGDIALLEGHELRWRQR
EWCIISRPWLTGQAILLLLQDTHGQRERLWLFADGMEKRNWRQLRLQLLNSKVQGNGWC
VVLWQCELRPSRLAQRFSLLLHGAVMLALLLPTWPASSGLVRMLLLVLVLLECIRSRRRIGRRQGDIALLEGHELRWRQR
EWCIISRPWLTGQAILLLLQDTHGQRERLWLFADGMEKRNWRQLRLQLLNSKVQGNGWC
Download Length: 420 bp
>T152397 NZ_CP066144:197055-197162 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA
Antitoxin
Download Length: 89 a.a. Molecular weight: 10498.07 Da Isoelectric Point: 6.4605
>AT152397 WP_004155593.1 NZ_CP050240:c3046680-3046414 [Erwinia amylovora]
MDITNKSRIHWACRRGMRELDISIMPFFQYEFDSLNDSDKRLFVRLLESDDPDLFNWLMNHGEPADVELKRMVALIQQRN
KQRGPVAM
MDITNKSRIHWACRRGMRELDISIMPFFQYEFDSLNDSDKRLFVRLLESDDPDLFNWLMNHGEPADVELKRMVALIQQRN
KQRGPVAM
Download Length: 267 bp
>AT152397 NZ_CP066144:c197006-196943 [Escherichia coli]
GTCTAGGTTCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT
GTCTAGGTTCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A830ZTB8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A831A3F0 |