Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3046014..3046680 Replicon chromosome
Accession NZ_CP050240
Organism Erwinia amylovora strain FB-20

Toxin (Protein)


Gene name cptA Uniprot ID A0A830ZTB8
Locus tag EGZ89_RS13785 Protein ID WP_004161808.1
Coordinates 3046014..3046433 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID D4HWC2
Locus tag EGZ89_RS13790 Protein ID WP_004155593.1
Coordinates 3046414..3046680 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGZ89_RS13770 3042006..3043685 + 1680 WP_004155599.1 type III effector -
EGZ89_RS13775 3044195..3045148 + 954 WP_004155597.1 DMT family transporter -
EGZ89_RS13780 3045378..3045896 + 519 WP_004155596.1 flavodoxin FldB -
EGZ89_RS13785 3046014..3046433 - 420 WP_004161808.1 hypothetical protein Toxin
EGZ89_RS13790 3046414..3046680 - 267 WP_004155593.1 FAD assembly factor SdhE Antitoxin
EGZ89_RS13795 3046906..3047892 + 987 WP_004155590.1 tRNA-modifying protein YgfZ -
EGZ89_RS13800 3047893..3048552 - 660 WP_004155588.1 hemolysin III family protein -
EGZ89_RS13805 3048765..3049373 + 609 WP_004155587.1 HD domain-containing protein -
EGZ89_RS13810 3049478..3050170 - 693 WP_004155586.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(8-79)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 16366.46 Da        Isoelectric Point: 11.9444

>T152397 WP_004161808.1 NZ_CP050240:c3046433-3046014 [Erwinia amylovora]
VVLWQCELRPSRLAQRFSLLLHGAVMLALLLPTWPASSGLVRMLLLVLVLLECIRSRRRIGRRQGDIALLEGHELRWRQR
EWCIISRPWLTGQAILLLLQDTHGQRERLWLFADGMEKRNWRQLRLQLLNSKVQGNGWC

Download         Length: 420 bp

>T152397 NZ_CP066144:197055-197162 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10498.07 Da        Isoelectric Point: 6.4605

>AT152397 WP_004155593.1 NZ_CP050240:c3046680-3046414 [Erwinia amylovora]
MDITNKSRIHWACRRGMRELDISIMPFFQYEFDSLNDSDKRLFVRLLESDDPDLFNWLMNHGEPADVELKRMVALIQQRN
KQRGPVAM

Download         Length: 267 bp

>AT152397 NZ_CP066144:c197006-196943 [Escherichia coli]
GTCTAGGTTCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A830ZTB8

Antitoxin

Source ID Structure
AlphaFold DB A0A831A3F0

References