Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2367224..2368202 Replicon chromosome
Accession NZ_CP050183
Organism Bacillus thuringiensis strain HER1410

Toxin (Protein)


Gene name spoIISA Uniprot ID -
Locus tag HBA75_RS12015 Protein ID WP_086412438.1
Coordinates 2367224..2367961 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID W8YZL5
Locus tag HBA75_RS12020 Protein ID WP_000237818.1
Coordinates 2368074..2368202 (+) Length 43 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HBA75_RS11990 2362839..2363246 + 408 WP_000072495.1 VOC family protein -
HBA75_RS11995 2363268..2363648 + 381 WP_000497671.1 methyltransferase -
HBA75_RS12000 2363806..2365491 - 1686 WP_033695152.1 alpha-keto acid decarboxylase family protein -
HBA75_RS12005 2365599..2366081 + 483 WP_000191886.1 MarR family winged helix-turn-helix transcriptional regulator -
HBA75_RS12010 2366248..2366985 + 738 WP_000594152.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
HBA75_RS12015 2367224..2367961 + 738 WP_086412438.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
HBA75_RS12020 2368074..2368202 + 129 WP_000237818.1 hypothetical protein Antitoxin
HBA75_RS12025 2368275..2368451 + 177 WP_000852629.1 stage II sporulation protein SB -
HBA75_RS12030 2368470..2368859 - 390 WP_016122519.1 YxeA family protein -
HBA75_RS12035 2369070..2370539 + 1470 WP_049107769.1 beta-Ala-His dipeptidase -
HBA75_RS12040 2370785..2371594 + 810 WP_000664544.1 C39 family peptidase -
HBA75_RS12045 2371620..2372222 + 603 WP_000517259.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(10-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28263.02 Da        Isoelectric Point: 9.0363

>T152385 WP_086412438.1 NZ_CP050183:2367224-2367961 [Bacillus thuringiensis]
MISNIRIGLFVLAIVFVVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIAGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T152385 NZ_CP066142:3247586-3247789 [Morganella morganii]
ATGACTAAACTTGACTATCTCATGCGCTTACGTAAGTGCACTTCGATCGAAACACTGGAACGTGTCATTGAGAAGAACAA
ATATGAACTGACTGATGACGAGCTGGAGGTTTTTTATTCAGCTGCCGATCATCGTCTGGCCGAATTAACCATGAATAAAC
TGTATGACAAAATCCCGGCGTCTGTCTGGAAATTTGTCCGTTAA

Antitoxin


Download         Length: 43 a.a.        Molecular weight: 5011.40 Da        Isoelectric Point: 3.9150

>AT152385 WP_000237818.1 NZ_CP050183:2368074-2368202 [Bacillus thuringiensis]
VVKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRKS

Download         Length: 129 bp

>AT152385 NZ_CP066142:3247164-3247523 [Morganella morganii]
ATGGACGAGTATTCTCCACGAAATTACGATATTGCGGTACTGAAGTATCTGTGTGATGAACTTTGCCGTGAAGGCACACA
AACTCTCATCAGAAGCAATAATTTTTGGGTTAATGATTTAGCCTCAGATTCAAACTTAAAACTTAACGAATTATTAGGTT
ACATTGCTGACGTGACCTGGAGTTTTAAGATAAAACATACACAAAATAAGGATCTCATCTCATTTGTCGATGAATACATC
GATGAAACTTACGCGCTGTTTGGTCAGATGGAAGTTTCATTTAATGATGTTGAGGAATGGAAGAAGATGGCATCACTGGT
AAGCAGCATGCTGACCAGCGAAGGGCATCTGGTCCACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB W8YZL5

References