Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-YefM
Location 3148589..3149088 Replicon chromosome
Accession NZ_CP050178
Organism Rhodococcus pyridinivorans strain YC-JH2

Toxin (Protein)


Gene name relE Uniprot ID V9XF56
Locus tag HBA53_RS14745 Protein ID WP_024102500.1
Coordinates 3148834..3149088 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0V9UIF5
Locus tag HBA53_RS14740 Protein ID WP_060652490.1
Coordinates 3148589..3148837 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HBA53_RS14725 (HBA53_14745) 3145652..3146902 - 1251 WP_064060749.1 alpha/beta fold hydrolase -
HBA53_RS14730 (HBA53_14750) 3146963..3147757 - 795 WP_019290512.1 LLM class F420-dependent oxidoreductase -
HBA53_RS26290 3148224..3148364 - 141 Protein_2900 hypothetical protein -
HBA53_RS14740 (HBA53_14760) 3148589..3148837 + 249 WP_060652490.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
HBA53_RS14745 (HBA53_14765) 3148834..3149088 + 255 WP_024102500.1 Txe/YoeB family addiction module toxin Toxin
HBA53_RS14750 (HBA53_14770) 3149082..3149405 - 324 WP_217579370.1 hypothetical protein -
HBA53_RS14755 (HBA53_14775) 3149666..3149977 - 312 WP_064060746.1 plasmid pRiA4b ORF-3 family protein -
HBA53_RS14760 (HBA53_14780) 3149974..3150471 - 498 WP_064060745.1 hypothetical protein -
HBA53_RS14765 (HBA53_14785) 3150628..3151584 + 957 WP_019290518.1 ERCC4 domain-containing protein -
HBA53_RS14775 (HBA53_14795) 3152147..3152359 + 213 WP_060652491.1 hypothetical protein -
HBA53_RS14780 (HBA53_14800) 3152517..3153143 - 627 WP_006550849.1 TetR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-70)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10077.42 Da        Isoelectric Point: 8.0410

>T152383 WP_024102500.1 NZ_CP050178:3148834-3149088 [Rhodococcus pyridinivorans]
VNITFTDEAWDDYQFWISTDRKQLKRVNELIRDCQRDPYSGIGKPERLRHALSGLWSRRIDKEHRLVYEVIDGALVIIAA
RYHY

Download         Length: 255 bp

>T152383 NZ_CP066142:1674694-1675047 [Morganella morganii]
GTGTGGAAGATAATTACAACAGATAATTTTGCAGCGTGGTTTGCTGCGCAGGATGACGGGGATCGTACAGCAATACTGGC
AGCGATGCTGGTATTGGAGAAGACCGGACCCGGTTTATCAGGACCGTATGCGGATACTGTGAAAGGTTCGCGTTATACGA
ATATGAAAGAGTTACGTATACAAAGCAGAGGGCAGCCGATAAGGGCATTTTTTGCATTCGACCCTGAACGGAGAGGTGTT
TTGCTGTGCGCAGGGTATAAAACCGGCAAAGAAAAACGTTTTTATATGCAGATGATTCCGCAGGCTGACCGTGAGTATAC
AGAATGGCTGAACAGGCCGGAAAACAGGAGTTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9276.56 Da        Isoelectric Point: 5.8315

>AT152383 WP_060652490.1 NZ_CP050178:3148589-3148837 [Rhodococcus pyridinivorans]
MAAITATEARKNFFPLVEQVNKDHTPVEIVSKRGNAVLMSKDDYDAMLETSYLMQSPANARRLLASMQRARGGEYTEREL
IE

Download         Length: 249 bp

>AT152383 NZ_CP066142:1675050-1675352 [Morganella morganii]
ATGGGAAAGTCACTCAGACAACTGCTGGCTGAGGAAAAGCCGGAAGTCGCGGCAGCAGCACGGGTTCAGGCGGACGAGAT
CCTGCTGAATATCCATCTGGCGGAACTGCGGGAGAAAGTGAACAAAACACAGGTGGAAATGGCACAGGCGCTGGGGATCA
AGCAGCCGACGGTCGCCGGGATGGAAAAACCGGGGCGTGATGTCAAATTATCCACGCTGAGACGCTATGTGGACGCCATC
GGCGGAAAACTGAATATTGATGTTGAGCTGCCGGACGGCACGCATTATATGTTCAGGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7M2XPP3

Antitoxin

Source ID Structure
AlphaFold DB A0A0V9UIF5

References