Detailed information of TA system TA152382

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 2393202..2393761
• Replicon: chromosome
• Accession: NZ_CP050178
• Organism: Rhodococcus pyridinivorans strain YC-JH2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HBA53_RS11185
• Protein ID: WP_024102981.1
• Coordinates: 2393202..2393480 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HBA53_RS11190
• Protein ID: WP_024102980.1
• Coordinates: 2393477..2393761 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HBA53_RS11155 (HBA53_11175)	2388320..2389039	+	720	WP_064060440.1	2OG-Fe(II) oxygenase	-
HBA53_RS11160 (HBA53_11180)	2389076..2390047	-	972	WP_064060430.1	phosphotriesterase	-
HBA53_RS11165 (HBA53_11185)	2390092..2390922	-	831	WP_064060431.1	SDR family oxidoreductase	-
HBA53_RS11170 (HBA53_11190)	2391043..2391705	+	663	WP_024102984.1	alpha-ketoglutarate-dependent dioxygenase AlkB	-
HBA53_RS11175 (HBA53_11195)	2391855..2392607	+	753	WP_064060432.1	cutinase family protein	-
HBA53_RS11180 (HBA53_11200)	2392666..2393145	+	480	WP_064060433.1	MarR family transcriptional regulator	-
HBA53_RS11185 (HBA53_11205)	2393202..2393480	-	279	WP_024102981.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HBA53_RS11190 (HBA53_11210)	2393477..2393761	-	285	WP_024102980.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HBA53_RS11195 (HBA53_11215)	2393981..2394799	-	819	WP_006551857.1	family 1 encapsulin nanocompartment shell protein	-
HBA53_RS11200 (HBA53_11220)	2394796..2395824	-	1029	WP_024102977.1	Dyp-type peroxidase	-
HBA53_RS11205 (HBA53_11225)	2395901..2397502	-	1602	WP_217580181.1	L-lactate permease	-
HBA53_RS11210 (HBA53_11230)	2397507..2397935	-	429	WP_064060434.1	HIT family protein	-
HBA53_RS11215 (HBA53_11235)	2397932..2398558	-	627	WP_231911981.1	TetR/AcrR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (34-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-71)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10268.82 Da
• Isoelectric Point: 10.2002

>T152382 WP_024102981.1 NZ_CP050178:c2393480-2393202 [Rhodococcus pyridinivorans]
MSTPDHPYRLVMARSAARAMARSLPEKVATAVYEFVTGPLLENPKRVGKPLNPPLAPAYSARRGEYRVLYLIDDANRTVE
VTAISHRADAYR

Nucleotide

• Length: 279 bp

>T152382 NZ_CP066140:3375353-3375556 [Morganella morganii]
ATGACTAAACTTGACTATCTCATGCGCTTACGTAAGTGCACTTCGATCGAAACACTGGAACGTGTCATTGAGAAGAACAA
ATATGAACTGACTGATGACGAGCTGGAGGTTTTTTATTCAGCTGCCGATCATCGTCTGGCCGAATTAACCATGAATAAAC
TGTATGACAAAATCCCGGCGTCTGTCTGGAAATTTGTCCGTTAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10494.56 Da
• Isoelectric Point: 4.2336

>AT152382 WP_024102980.1 NZ_CP050178:c2393761-2393477 [Rhodococcus pyridinivorans]
MTTLPVADARAQLSRLVDEAERTHERFEITRNGHRAAVLLGADDYDAMQETIAVLSDTDLLRAHVEGRTEVESGDVVDVQ
ELTQLMRDARSSEE

Nucleotide

• Length: 285 bp

>AT152382 NZ_CP066140:3374931-3375290 [Morganella morganii]
ATGGACGAGTATTCTCCACGAAATTACGATATTGCGGTACTGAAGTATCTGTGTGATGAACTTTGCCGTGAAGGCACACA
AACTCTCATCAGAAGCAATAATTTTTGGGTTAATGATTTAGCCTCAGATTCAAACTTAAAACTTAACGAATTATTAGGTT
ACATTGCTGACGTGACCTGGAGTTTTAAGATAAAACATACACAAAATAAGGATCTCATCTCATTTGTCGATGAATACATC
GATGAAACTTACGCGCTGTTTGGTCAGATGGAAGTTTCATTTAATGATGTTGAGGAATGGAAGAAGATGGCATCACTGGT
AAGCAGCATGCTGACCAGCGAAGGGCATCTGGTCCACTAA