Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1689394..1690056 Replicon chromosome
Accession NZ_CP050175
Organism Streptococcus pneumoniae strain PZ900701590

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag HA248_RS08675 Protein ID WP_172964105.1
Coordinates 1689883..1690056 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag HA248_RS08670 Protein ID WP_000961810.1
Coordinates 1689394..1689846 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HA248_RS08645 1685370..1686404 - 1035 WP_000747915.1 ATP-binding protein -
HA248_RS08650 1686514..1686672 - 159 WP_001862824.1 hypothetical protein -
HA248_RS08655 1686653..1687741 - 1089 WP_000719722.1 M50 family metallopeptidase -
HA248_RS08660 1687760..1688230 - 471 WP_000257089.1 DUF3013 family protein -
HA248_RS08665 1688508..1689322 - 815 Protein_1699 IS5-like element IS1515 family transposase -
HA248_RS08670 1689394..1689846 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HA248_RS08675 1689883..1690056 - 174 WP_172964105.1 type II toxin-antitoxin system HicA family toxin Toxin
HA248_RS08680 1690199..1690378 - 180 WP_001809903.1 hypothetical protein -
HA248_RS08685 1690543..1690781 - 239 Protein_1703 hypothetical protein -
HA248_RS08690 1691051..1692322 + 1272 WP_001113208.1 replication-associated recombination protein A -
HA248_RS08700 1692868..1694187 - 1320 WP_000502552.1 glycoside hydrolase family 32 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6354.45 Da        Isoelectric Point: 10.8214

>T152380 WP_172964105.1 NZ_CP050175:c1690056-1689883 [Streptococcus pneumoniae]
MTQKEMVKLLTAHGWIKTRGGKGSHIKIDKQGERPITILHGELNKYTERGIGKQAGL

Download         Length: 174 bp

>T152380 NZ_CP050175:c1690056-1689883 [Streptococcus pneumoniae]
ATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCATATTAA
AATCGATAAGCAAGGGGAAAGACCTATCACAATCCTTCATGGTGAGCTGAATAAGTACACTGAAAGAGGGATAGGAAAGC
AAGCTGGGTTGTAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT152380 WP_000961810.1 NZ_CP050175:c1689846-1689394 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT152380 NZ_CP050175:c1689846-1689394 [Streptococcus pneumoniae]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTGACCATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References