Detailed information of TA system TA152380

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1689394..1690056
• Replicon: chromosome
• Accession: NZ_CP050175
• Organism: Streptococcus pneumoniae strain PZ900701590

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: HA248_RS08675
• Protein ID: WP_172964105.1
• Coordinates: 1689883..1690056 (-)
• Length: 58 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: G0IC64
• Locus tag: HA248_RS08670
• Protein ID: WP_000961810.1
• Coordinates: 1689394..1689846 (-)
• Length: 151 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HA248_RS08645	1685370..1686404	-	1035	WP_000747915.1	ATP-binding protein	-
HA248_RS08650	1686514..1686672	-	159	WP_001862824.1	hypothetical protein	-
HA248_RS08655	1686653..1687741	-	1089	WP_000719722.1	M50 family metallopeptidase	-
HA248_RS08660	1687760..1688230	-	471	WP_000257089.1	DUF3013 family protein	-
HA248_RS08665	1688508..1689322	-	815	Protein_1699	IS5-like element IS1515 family transposase	-
HA248_RS08670	1689394..1689846	-	453	WP_000961810.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HA248_RS08675	1689883..1690056	-	174	WP_172964105.1	type II toxin-antitoxin system HicA family toxin	Toxin
HA248_RS08680	1690199..1690378	-	180	WP_001809903.1	hypothetical protein	-
HA248_RS08685	1690543..1690781	-	239	Protein_1703	hypothetical protein	-
HA248_RS08690	1691051..1692322	+	1272	WP_001113208.1	replication-associated recombination protein A	-
HA248_RS08700	1692868..1694187	-	1320	WP_000502552.1	glycoside hydrolase family 32 protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-57)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (17-114)

Sequences

Toxin

Protein

• Length: 58 a.a.
• Molecular weight: 6354.45 Da
• Isoelectric Point: 10.8214

>T152380 WP_172964105.1 NZ_CP050175:c1690056-1689883 [Streptococcus pneumoniae]
MTQKEMVKLLTAHGWIKTRGGKGSHIKIDKQGERPITILHGELNKYTERGIGKQAGL

Nucleotide

• Length: 174 bp

>T152380 NZ_CP050175:c1690056-1689883 [Streptococcus pneumoniae]
ATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCATATTAA
AATCGATAAGCAAGGGGAAAGACCTATCACAATCCTTCATGGTGAGCTGAATAAGTACACTGAAAGAGGGATAGGAAAGC
AAGCTGGGTTGTAA

Antitoxin

Protein

• Length: 151 a.a.
• Molecular weight: 16659.46 Da
• Isoelectric Point: 3.7220

>AT152380 WP_000961810.1 NZ_CP050175:c1689846-1689394 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Nucleotide

• Length: 453 bp

>AT152380 NZ_CP050175:c1689846-1689394 [Streptococcus pneumoniae]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTGACCATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Structures

Antitoxin

• AlphaFold DB: G0IC64