Detailed information of TA system TA152378

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1187410..1187908
• Replicon: chromosome
• Accession: NZ_CP050175
• Organism: Streptococcus pneumoniae strain PZ900701590

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HA248_RS06070
• Protein ID: WP_001812387.1
• Coordinates: 1187410..1187664 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B1IC20
• Locus tag: HA248_RS06075
• Protein ID: WP_000208080.1
• Coordinates: 1187666..1187908 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HA248_RS06065	1185449..1187335	-	1887	WP_000150984.1	Eco57I restriction-modification methylase domain-containing protein	-
HA248_RS06070	1187410..1187664	-	255	WP_001812387.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HA248_RS06075	1187666..1187908	-	243	WP_000208080.1	hypothetical protein	Antitoxin
HA248_RS06080	1187999..1188808	-	810	WP_001289493.1	MBL fold metallo-hydrolase	-
HA248_RS06085	1188810..1190159	-	1350	WP_000886210.1	cell wall metabolism sensor histidine kinase VicK	-
HA248_RS06090	1190152..1190856	-	705	WP_000722076.1	response regulator transcription factor	-
HA248_RS06095	1190911..1192086	-	1176	WP_000886147.1	A/G-specific adenine glycosylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-84)

Antitoxin

• Protein of unknown function DUF6290 (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10110.85 Da
• Isoelectric Point: 10.7632

>T152378 WP_001812387.1 NZ_CP050175:c1187664-1187410 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQINVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Nucleotide

• Length: 255 bp

>T152378 NZ_CP066138:3371079-3371282 [Morganella morganii]
ATGACTAAACTTGACTATCTCATGCGCTTACGTAAGTGCACTTCGATCGAAACACTGGAACGTGTCATTGAGAAGAACAA
ATATGAACTGACTGATGACGAGCTGGAGGTTTTTTATTCAGCTGCCGATCATCGTCTGGCCGAATTAACCATGAATAAAC
TGTATGACAAAATCCCGGCGTCTGTCTGGAAATTTGTCCGTTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9205.46 Da
• Isoelectric Point: 4.0527

>AT152378 WP_000208080.1 NZ_CP050175:c1187908-1187666 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Nucleotide

• Length: 243 bp

>AT152378 NZ_CP066138:3370657-3371016 [Morganella morganii]
ATGGACGAGTATTCTCCACGAAATTACGATATTGCGGTACTGAAGTATCTGTGTGATGAACTTTGCCGTGAAGGCACACA
AACTCTCATCAGAAGCAATAATTTTTGGGTTAATGATTTAGCCTCAGATTCAAACTTAAAACTTAACGAATTATTAGGTT
ACATTGCTGACGTGACCTGGAGTTTTAAGATAAAACATACACAAAATAAGGATCTCATCTCATTTGTCGATGAATACATC
GATGAAACTTACGCGCTGTTTGGTCAGATGGAAGTTTCATTTAATGATGTTGAGGAATGGAAGAAGATGGCATCACTGGT
AAGCAGCATGCTGACCAGCGAAGGGCATCTGGTCCACTAA

Structures

Antitoxin

• AlphaFold DB: A0A064C2J7