Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) zeta-pezA/zeta-couple_hipB
Location 1109968..1111214 Replicon chromosome
Accession NZ_CP050175
Organism Streptococcus pneumoniae strain PZ900701590

Toxin (Protein)


Gene name zeta Uniprot ID -
Locus tag HA248_RS05705 Protein ID WP_000405354.1
Coordinates 1110444..1111214 (+) Length 257 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID -
Locus tag HA248_RS05700 Protein ID WP_000579623.1
Coordinates 1109968..1110444 (+) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HA248_RS05660 1106249..1106533 + 285 WP_000969645.1 hypothetical protein -
HA248_RS05665 1106547..1106843 + 297 WP_000998888.1 hypothetical protein -
HA248_RS05670 1106857..1107054 - 198 WP_074187117.1 hypothetical protein -
HA248_RS05675 1107190..1107831 + 642 WP_000933083.1 hypothetical protein -
HA248_RS05680 1107841..1108926 + 1086 WP_000401905.1 toprim domain-containing protein -
HA248_RS05685 1108977..1109210 + 234 WP_000152419.1 hypothetical protein -
HA248_RS05690 1109207..1109590 + 384 WP_000159213.1 hypothetical protein -
HA248_RS05695 1109628..1109900 + 273 WP_000495438.1 hypothetical protein -
HA248_RS05700 1109968..1110444 + 477 WP_000579623.1 helix-turn-helix domain-containing protein Antitoxin
HA248_RS05705 1110444..1111214 + 771 WP_000405354.1 zeta toxin family protein Toxin
HA248_RS05710 1111470..1112153 + 684 WP_000492698.1 LexA family transcriptional regulator -
HA248_RS05715 1112156..1113571 + 1416 WP_000118332.1 Y-family DNA polymerase -
HA248_RS05720 1113568..1113933 + 366 WP_000981955.1 hypothetical protein -
HA248_RS05725 1113923..1114213 + 291 WP_001080184.1 hypothetical protein -
HA248_RS05730 1114508..1114864 + 357 WP_000827835.1 hypothetical protein -
HA248_RS05735 1114869..1115234 + 366 WP_000401236.1 plasmid mobilization relaxosome protein MobC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element erm(B) / tet(M) - 1042767..1124303 81536


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(25-214)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 257 a.a.        Molecular weight: 29234.14 Da        Isoelectric Point: 7.5403

>T152377 WP_000405354.1 NZ_CP050175:1110444-1111214 [Streptococcus pneumoniae]
VEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTELSHLGYNLLIEGTLRTVDVPKKTAQLLKNKGYEVQLALIATKPKLSYLSTLIRYEE
LYAINPNQARATPKEHHDFIVNHLVNNTRQLEELAIFERIQIYQRDRSCVYDSGEDKTSAATVLHDLLFGEWNQVEKEML
KSGEERLKDLTNRNGC

Download         Length: 771 bp

>T152377 NZ_CP066138:2152740-2153084 [Morganella morganii]
GTGTGGACAGTATTATTAACGGATTATTTTAATGAATGGTTGTCAAAACAAGATACCCGGATGAAAGAAAAAGTGCTCGC
ATCTCTTGGCAATCTTGAAATTTATGGCCCTGTTCTGACAAGACCTTATGTTGATACAGTTAAAACTTCTCAGTACCCGA
ATATGAAAGAATTGAGAATTTGGCATGCTGGTCGTGCAATACGTGCATTTTTTGCCTTTGATCCTGAAAGGCAGGCCATT
ATTTTATGTGCCGGAGATAAAGGGAAGGATAAACGATTTTATCAGACGATGATTCGTATTGCGGACGAACAATTTTCCTC
ATATCTTTCAGCAACGCAGGAATAA

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18259.71 Da        Isoelectric Point: 4.4258

>AT152377 WP_000579623.1 NZ_CP050175:1109968-1110444 [Streptococcus pneumoniae]
MIGKNIKSLRKTHELTQPEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA

Download         Length: 477 bp

>AT152377 NZ_CP066138:2153089-2153388 [Morganella morganii]
ATGAAAACATTACAGGAAGTGATAGCGGCTCAATCACCGGAGAGCCGTGAGCGGATAAAACAACTGACTGATGAGCTGGT
TCTTGAAACCGGACTGCAACTTCTCAGAGAAGAACTTCATATCTCTCAGAAAACGCTGGCAAATAATCTTGGTATATCAC
AGCCGGCTGTTACTCAGATTGAGCAGCGCGGTAATGATATCAAACTGGCAACGCTGAAACGCTATATTGAGGCAATGGGC
GGAACACTTCGTCTGACGATTGAACTACCGACCGGTGATAACCGGATTTTTCGTGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References