Detailed information of TA system TA152377

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): zeta-pezA/zeta-couple_hipB
• Location: 1109968..1111214
• Replicon: chromosome
• Accession: NZ_CP050175
• Organism: Streptococcus pneumoniae strain PZ900701590

Toxin (Protein)

• Gene name: zeta
• Uniprot ID: -
• Locus tag: HA248_RS05705
• Protein ID: WP_000405354.1
• Coordinates: 1110444..1111214 (+)
• Length: 257 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: -
• Locus tag: HA248_RS05700
• Protein ID: WP_000579623.1
• Coordinates: 1109968..1110444 (+)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HA248_RS05660	1106249..1106533	+	285	WP_000969645.1	hypothetical protein	-
HA248_RS05665	1106547..1106843	+	297	WP_000998888.1	hypothetical protein	-
HA248_RS05670	1106857..1107054	-	198	WP_074187117.1	hypothetical protein	-
HA248_RS05675	1107190..1107831	+	642	WP_000933083.1	hypothetical protein	-
HA248_RS05680	1107841..1108926	+	1086	WP_000401905.1	toprim domain-containing protein	-
HA248_RS05685	1108977..1109210	+	234	WP_000152419.1	hypothetical protein	-
HA248_RS05690	1109207..1109590	+	384	WP_000159213.1	hypothetical protein	-
HA248_RS05695	1109628..1109900	+	273	WP_000495438.1	hypothetical protein	-
HA248_RS05700	1109968..1110444	+	477	WP_000579623.1	helix-turn-helix domain-containing protein	Antitoxin
HA248_RS05705	1110444..1111214	+	771	WP_000405354.1	zeta toxin family protein	Toxin
HA248_RS05710	1111470..1112153	+	684	WP_000492698.1	LexA family transcriptional regulator	-
HA248_RS05715	1112156..1113571	+	1416	WP_000118332.1	Y-family DNA polymerase	-
HA248_RS05720	1113568..1113933	+	366	WP_000981955.1	hypothetical protein	-
HA248_RS05725	1113923..1114213	+	291	WP_001080184.1	hypothetical protein	-
HA248_RS05730	1114508..1114864	+	357	WP_000827835.1	hypothetical protein	-
HA248_RS05735	1114869..1115234	+	366	WP_000401236.1	plasmid mobilization relaxosome protein MobC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	erm(B) / tet(M)	-	1042767..1124303	81536

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (25-214)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 257 a.a.
• Molecular weight: 29234.14 Da
• Isoelectric Point: 7.5403

>T152377 WP_000405354.1 NZ_CP050175:1110444-1111214 [Streptococcus pneumoniae]
VEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTELSHLGYNLLIEGTLRTVDVPKKTAQLLKNKGYEVQLALIATKPKLSYLSTLIRYEE
LYAINPNQARATPKEHHDFIVNHLVNNTRQLEELAIFERIQIYQRDRSCVYDSGEDKTSAATVLHDLLFGEWNQVEKEML
KSGEERLKDLTNRNGC

Nucleotide

• Length: 771 bp

>T152377 NZ_CP066138:2152740-2153084 [Morganella morganii]
GTGTGGACAGTATTATTAACGGATTATTTTAATGAATGGTTGTCAAAACAAGATACCCGGATGAAAGAAAAAGTGCTCGC
ATCTCTTGGCAATCTTGAAATTTATGGCCCTGTTCTGACAAGACCTTATGTTGATACAGTTAAAACTTCTCAGTACCCGA
ATATGAAAGAATTGAGAATTTGGCATGCTGGTCGTGCAATACGTGCATTTTTTGCCTTTGATCCTGAAAGGCAGGCCATT
ATTTTATGTGCCGGAGATAAAGGGAAGGATAAACGATTTTATCAGACGATGATTCGTATTGCGGACGAACAATTTTCCTC
ATATCTTTCAGCAACGCAGGAATAA

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18259.71 Da
• Isoelectric Point: 4.4258

>AT152377 WP_000579623.1 NZ_CP050175:1109968-1110444 [Streptococcus pneumoniae]
MIGKNIKSLRKTHELTQPEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA

Nucleotide

• Length: 477 bp

>AT152377 NZ_CP066138:2153089-2153388 [Morganella morganii]
ATGAAAACATTACAGGAAGTGATAGCGGCTCAATCACCGGAGAGCCGTGAGCGGATAAAACAACTGACTGATGAGCTGGT
TCTTGAAACCGGACTGCAACTTCTCAGAGAAGAACTTCATATCTCTCAGAAAACGCTGGCAAATAATCTTGGTATATCAC
AGCCGGCTGTTACTCAGATTGAGCAGCGCGGTAATGATATCAAACTGGCAACGCTGAAACGCTATATTGAGGCAATGGGC
GGAACACTTCGTCTGACGATTGAACTACCGACCGGTGATAACCGGATTTTTCGTGTCTGA