Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 59608..60130 Replicon plasmid pSTB20-1T
Accession NZ_CP050174
Organism Escherichia coli strain STB20-1

Toxin (Protein)


Gene name relE Uniprot ID G3CAN5
Locus tag FIP50_RS23065 Protein ID WP_000220560.1
Coordinates 59849..60130 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag FIP50_RS23060 Protein ID WP_000121743.1
Coordinates 59608..59859 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FIP50_RS23275 55269..55551 + 283 Protein_68 CopG family transcriptional regulator -
FIP50_RS23040 55576..56553 + 978 WP_024245156.1 hypothetical protein -
FIP50_RS23045 56550..56975 - 426 WP_000202942.1 hypothetical protein -
FIP50_RS23050 57044..57493 - 450 Protein_71 hypothetical protein -
FIP50_RS23055 57533..58369 - 837 WP_001050931.1 replication initiation protein -
FIP50_RS23060 59608..59859 + 252 WP_000121743.1 plasmid stabilization protein Antitoxin
FIP50_RS23065 59849..60130 + 282 WP_000220560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FIP50_RS23070 60205..60902 + 698 Protein_75 IS1 family transposase -
FIP50_RS23075 61048..61305 + 258 WP_105278499.1 hypothetical protein -
FIP50_RS23080 61342..62310 - 969 WP_077783444.1 IS5 family transposase -
FIP50_RS23085 62345..62619 + 275 Protein_78 peptidoglycan DD-metalloendopeptidase family protein -
FIP50_RS23090 62653..62850 - 198 WP_000843497.1 DUF2933 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid mef(B) / sul3 / dfrA5 / tet(X4) / floR / tet(A) / blaTEM-1B / tet(M) / qnrS1 - 1..97366 97366


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11005.83 Da        Isoelectric Point: 10.5938

>T152376 WP_000220560.1 NZ_CP050174:59849-60130 [Escherichia coli]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADLR

Download         Length: 282 bp

>T152376 NZ_CP066138:1693019-1693372 [Morganella morganii]
GTGTGGAAGATAATTACAACAGATAATTTTGCAGCGTGGTTTGCTGCGCAGGATGACGGGGATCGTACAGCAATACTGGC
AGCGATGCTGGTATTGGAGAAGACCGGACCCGGTTTATCAGGACCGTATGCGGATACTGTGAAAGGTTCGCGTTATACGA
ATATGAAAGAGTTACGTATACAAAGCAGAGGGCAGCCGATAAGGGCATTTTTTGCATTCGACCCTGAACGGAGAGGTGTT
TTGCTGTGCGCAGGGTATAAAACCGGCAAAGAAAAACGTTTTTATATGCAGATGATTCCGCAGGCTGACCGTGAGTATAC
AGAATGGCTGAACAGGCCGGAAAACAGGAGTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT152376 WP_000121743.1 NZ_CP050174:59608-59859 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp

>AT152376 NZ_CP066138:1693375-1693677 [Morganella morganii]
ATGGGAAAGTCACTCAGACAACTGCTGGCTGAGGAAAAGCCGGAAGTCGCGGCAGCAGCACGGGTTCAGGCGGACGAGAT
CCTGCTGAATATCCATCTGGCGGAACTGCGGGAGAAAGTGAACAAAACACAGGTGGAAATGGCACAGGCGCTGGGGATCA
AGCAGCCGACGGTCGCCGGGATGGAAAAACCGGGGCGTGATGTCAAATTATCCACGCTGAGACGCTATGTGGACGCCATC
GGCGGAAAACTGAATATTGATGTTGAGCTGCCGGACGGCACGCATTATATGTTCAGGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G3CAN5

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References