Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2371002..2372590 Replicon chromosome
Accession NZ_CP050173
Organism Escherichia coli strain STB20-1

Toxin (Protein)


Gene name hipA Uniprot ID S1ELM3
Locus tag FIP50_RS11590 Protein ID WP_001125439.1
Coordinates 2371268..2372590 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag FIP50_RS11585 Protein ID WP_001301023.1
Coordinates 2371002..2371268 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FIP50_RS11585 2371002..2371268 + 267 WP_001301023.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
FIP50_RS11590 2371268..2372590 + 1323 WP_001125439.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
FIP50_RS11595 2372829..2374352 + 1524 WP_032223311.1 site-specific integrase -
FIP50_RS11600 2374315..2375922 + 1608 WP_041124212.1 integrase -
FIP50_RS11605 2375998..2377226 + 1229 WP_088895425.1 IS3-like element IS2 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49275.82 Da        Isoelectric Point: 8.2482

>T152370 WP_001125439.1 NZ_CP050173:2371268-2372590 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTHPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVESNVLRLHGRLSREYGSK

Download         Length: 1323 bp

>T152370 NZ_CP066133:2137217-2137561 [Morganella morganii]
GTGTGGACAGTATTATTAACGGATTATTTTAATGAATGGTTGTCAAAACAAGATACCCGGATGAAAGAAAAAGTGCTCGC
ATCTCTTGGCAATCTTGAAATTTATGGCCCTGTTCTGACAAGACCTTATGTTGATACAGTTAAAACTTCTCAGTACCCGA
ATATGAAAGAATTGAGAATTTGGCATGCTGGTCGTGCAATACGTGCATTTTTTGCCTTTGATCCTGAAAGGCAGGCCATT
ATTTTATGTGCCGGAGATAAAGGGAAGGATAAACGATTTTATCAGACGATGATTCGTATTGCGGACGAACAATTTTCCTC
ATATCTTTCAGCAACGCAGGAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10016.38 Da        Isoelectric Point: 6.2267

>AT152370 WP_001301023.1 NZ_CP050173:2371002-2371268 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDAKNASPES
TEQQNLEW

Download         Length: 267 bp

>AT152370 NZ_CP066133:2137566-2137865 [Morganella morganii]
ATGAAAACATTACAGGAAGTGATAGCGGCTCAATCACCGGAGAGCCGTGAGCGGATAAAACAACTGACTGATGAGCTGGT
TCTTGAAACCGGACTGCAACTTCTCAGAGAAGAACTTCATATCTCTCAGAAAACGCTGGCAAATAATCTTGGTATATCAC
AGCCGGCTGTTACTCAGATTGAGCAGCGCGGTAATGATATCAAACTGGCAACGCTGAAACGCTATATTGAGGCAATGGGC
GGAACACTTCGTCTGACGATTGAACTACCGACCGGTGATAACCGGATTTTTCGTGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5K98
PDB 3TPV
PDB 3DNV
PDB 3TPD
PDB 3HZI
PDB 3FBR
PDB 4YG7
PDB 3TPE
PDB 2WIU
PDB 3DNT
PDB 3TPB
PDB 3TPT
PDB 3DNU

Antitoxin

Source ID Structure

References