Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1891757..1892588 Replicon chromosome
Accession NZ_CP050173
Organism Escherichia coli strain STB20-1

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag FIP50_RS09115 Protein ID WP_000854814.1
Coordinates 1891757..1892131 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag FIP50_RS09120 Protein ID WP_001285585.1
Coordinates 1892220..1892588 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FIP50_RS09075 1887153..1888319 + 1167 WP_016247321.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
FIP50_RS09080 1888438..1888911 + 474 WP_001105415.1 DNA gyrase inhibitor SbmC -
FIP50_RS09085 1889109..1890167 + 1059 WP_064670363.1 FUSC family protein -
FIP50_RS09090 1890339..1890668 + 330 WP_000450409.1 DUF496 family protein -
FIP50_RS09095 1890769..1890951 - 183 WP_001016348.1 hypothetical protein -
FIP50_RS09100 1891023..1891151 + 129 Protein_1777 transposase domain-containing protein -
FIP50_RS09105 1891440..1891553 - 114 WP_001161660.1 DUF957 domain-containing protein -
FIP50_RS09110 1891566..1891760 - 195 WP_000988600.1 hypothetical protein -
FIP50_RS09115 1891757..1892131 - 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
FIP50_RS09120 1892220..1892588 - 369 WP_001285585.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
FIP50_RS09125 1892662..1892883 - 222 WP_000692323.1 DUF987 domain-containing protein -
FIP50_RS09130 1892946..1893422 - 477 WP_001186773.1 RadC family protein -
FIP50_RS09135 1893438..1893917 - 480 WP_000860076.1 antirestriction protein -
FIP50_RS09140 1893999..1894820 - 822 WP_064670364.1 DUF945 domain-containing protein -
FIP50_RS09145 1895041..1895451 - 411 WP_000846713.1 hypothetical protein -
FIP50_RS09150 1895467..1896150 - 684 WP_000775500.1 hypothetical protein -
FIP50_RS09155 1896286..1897356 - 1071 WP_000102643.1 patatin-like phospholipase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1845807..1900475 54668


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T152361 WP_000854814.1 NZ_CP050173:c1892131-1891757 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T152361 NZ_CP066130:1686197-1686550 [Morganella morganii]
GTGTGGAAGATAATTACAACAGATAATTTTGCAGCGTGGTTTGCTGCGCAGGATGACGGGGATCGTACAGCAATACTGGC
AGCGATGCTGGTATTGGAGAAGACCGGACCCGGTTTATCAGGACCGTATGCGGATACTGTGAAAGGTTCGCGTTATACGA
ATATGAAAGAGTTACGTATACAAAGCAGAGGGCAGCCGATAAGGGCATTTTTTGCATTCGACCCTGAACGGAGAGGTGTT
TTGCTGTGCGCAGGGTATAAAACCGGCAAAGAAAAACGTTTTTATATGCAGATGATTCCGCAGGCTGACCGTGAGTATAC
AGAATGGCTGAACAGGCCGGAAAACAGGAGTTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT152361 WP_001285585.1 NZ_CP050173:c1892588-1892220 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT152361 NZ_CP066130:1686553-1686855 [Morganella morganii]
ATGGGAAAGTCACTCAGACAACTGCTGGCTGAGGAAAAGCCGGAAGTCGCGGCAGCAGCACGGGTTCAGGCGGACGAGAT
CCTGCTGAATATCCATCTGGCGGAACTGCGGGAGAAAGTGAACAAAACACAGGTGGAAATGGCACAGGCGCTGGGGATCA
AGCAGCCGACGGTCGCCGGGATGGAAAAACCGGGGCGTGATGTCAAATTATCCACGCTGAGACGCTATGTGGACGCCATC
GGCGGAAAACTGAATATTGATGTTGAGCTGCCGGACGGCACGCATTATATGTTCAGGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References