Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/PRK09907-MazE |
| Location | 1019275..1019858 | Replicon | chromosome |
| Accession | NZ_CP050173 | ||
| Organism | Escherichia coli strain STB20-1 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | S1EZP4 |
| Locus tag | FIP50_RS04885 | Protein ID | WP_000254738.1 |
| Coordinates | 1019523..1019858 (+) | Length | 112 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | S1P3W5 |
| Locus tag | FIP50_RS04880 | Protein ID | WP_000581937.1 |
| Coordinates | 1019275..1019523 (+) | Length | 83 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FIP50_RS04870 | 1015614..1016915 | + | 1302 | WP_001556187.1 | 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD | - |
| FIP50_RS04875 | 1016963..1019197 | + | 2235 | WP_000226815.1 | GTP pyrophosphokinase | - |
| FIP50_RS04880 | 1019275..1019523 | + | 249 | WP_000581937.1 | type II toxin-antitoxin system antitoxin MazE | Antitoxin |
| FIP50_RS04885 | 1019523..1019858 | + | 336 | WP_000254738.1 | endoribonuclease MazF | Toxin |
| FIP50_RS04890 | 1019929..1020720 | + | 792 | WP_001071648.1 | nucleoside triphosphate pyrophosphohydrolase | - |
| FIP50_RS04895 | 1020948..1022585 | + | 1638 | WP_000210878.1 | CTP synthase (glutamine hydrolyzing) | - |
| FIP50_RS04900 | 1022673..1023971 | + | 1299 | WP_000036723.1 | phosphopyruvate hydratase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 112 a.a. Molecular weight: 12098.04 Da Isoelectric Point: 8.2618
>T152360 WP_000254738.1 NZ_CP050173:1019523-1019858 [Escherichia coli]
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKS
IAWRARGATKKGTVAPEELQLIKAKINVLIG
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKS
IAWRARGATKKGTVAPEELQLIKAKINVLIG
Download Length: 336 bp
>T152360 NZ_CP066129:c3783830-3782505 [Morganella morganii]
ATGAGCCGGACACAACAACGTTTAGCAATATGGATGAACGGAATCCGTGTCGGATTCTGGGAAAAGATCAGAGGGGAAGA
TCGGCTGCACTATCTCCCGGAGTGGGTTGCTGATGAGCAAGGCAGACAGCTGTCTCTTTCATTGCCGTTCACGCCGGGTA
ATCAGGTCTGGCGCGGAAATGTTGTGCGTGATTACTTTGATAATTTATTACCGGATAGTGAGGATATCCGCAGGCGTCTG
GCGATGCGCTACAGAGCGGAAAGCCTGGAACCTTTTGACCTGCTGGCCGAACTGGGAAGAGATTGTGTCGGGGCAATTCA
ATTGCTGCATCCGGATGATGAACCGGCAGACTTATTTTCTGTCAATTACCGGCCGCTTTCGGAAGCGGATATTGCAGCGA
TACTGCGTAATACCACAACGTCAATTCCCGGTCGTCATAGCGATGATGAAGAGCTGCGGTTATCTATCGCCGGTGCGCAG
GAAAAAACGGCTTTACTGTGGAATGATGGACAATGGTGTTTACCGGAAGGTAATACACCGACGACTCATATTTTCAAGCT
ACCGCTTGGCTTAGTCGGCAATATGAAGGCTGATATGAGCACATCAGTTGAAAATGAATGGCTGTGTTCGCTGATCCTTG
AACACTATGGTATTCCTGTTGCAAAAACGCAGATTGCGCAGTTTGAAGACCAGAAAGTCTTGATTGTGGATCGCTTTGAC
CGGCGCTGGTCAACCGACAGACAGTGGATTGTCCGTTTGCCGCAGGAGGACATGTGTCAGGCACTGGGTGTTTCACCGCT
GCGGAAATATCAGGCTGATGGTGGCCCGGGTATCACGGATATCATGGGAATACTGAGTCATTCCGAGCAGGCAGAGCAGG
ACAGAGAAACCTTTTTTAAAGCACAGATTATTTTCTGGCTGATGGCCGCCACAGACGGGCATGCCAAAAACTTCAGTATT
TCCATGGAACCGCAAAACCGTTACCGCCTGACGCCTTTGTATGATGTTCTATCTGCATGGCCGCTGATCGGTAATGGTAA
CAACCAGATTGCCTGGCAGAAATGTAAACTGGCAATGGCCGTCCGGGGAAGTAGTAACTATTACCTGATGAGCAAAATTC
AGCGCCGCCATTGGATCAAGCACGGCGAGACGGTGGGATTTGAAAAACAACAAGTTGAAGCAATGCTGGATGACATTATC
GGCCGGACACCAGAAGTGATTGAGCGTGTGAGTGCGTTGTTGCCGGAGGGGTTTCCGGTTGGGGTTGCGGAGAGAGTTTT
TGGGGGAATGAGAAAATTAAATCCAGTATTAACAAGAGGAGTGTGA
ATGAGCCGGACACAACAACGTTTAGCAATATGGATGAACGGAATCCGTGTCGGATTCTGGGAAAAGATCAGAGGGGAAGA
TCGGCTGCACTATCTCCCGGAGTGGGTTGCTGATGAGCAAGGCAGACAGCTGTCTCTTTCATTGCCGTTCACGCCGGGTA
ATCAGGTCTGGCGCGGAAATGTTGTGCGTGATTACTTTGATAATTTATTACCGGATAGTGAGGATATCCGCAGGCGTCTG
GCGATGCGCTACAGAGCGGAAAGCCTGGAACCTTTTGACCTGCTGGCCGAACTGGGAAGAGATTGTGTCGGGGCAATTCA
ATTGCTGCATCCGGATGATGAACCGGCAGACTTATTTTCTGTCAATTACCGGCCGCTTTCGGAAGCGGATATTGCAGCGA
TACTGCGTAATACCACAACGTCAATTCCCGGTCGTCATAGCGATGATGAAGAGCTGCGGTTATCTATCGCCGGTGCGCAG
GAAAAAACGGCTTTACTGTGGAATGATGGACAATGGTGTTTACCGGAAGGTAATACACCGACGACTCATATTTTCAAGCT
ACCGCTTGGCTTAGTCGGCAATATGAAGGCTGATATGAGCACATCAGTTGAAAATGAATGGCTGTGTTCGCTGATCCTTG
AACACTATGGTATTCCTGTTGCAAAAACGCAGATTGCGCAGTTTGAAGACCAGAAAGTCTTGATTGTGGATCGCTTTGAC
CGGCGCTGGTCAACCGACAGACAGTGGATTGTCCGTTTGCCGCAGGAGGACATGTGTCAGGCACTGGGTGTTTCACCGCT
GCGGAAATATCAGGCTGATGGTGGCCCGGGTATCACGGATATCATGGGAATACTGAGTCATTCCGAGCAGGCAGAGCAGG
ACAGAGAAACCTTTTTTAAAGCACAGATTATTTTCTGGCTGATGGCCGCCACAGACGGGCATGCCAAAAACTTCAGTATT
TCCATGGAACCGCAAAACCGTTACCGCCTGACGCCTTTGTATGATGTTCTATCTGCATGGCCGCTGATCGGTAATGGTAA
CAACCAGATTGCCTGGCAGAAATGTAAACTGGCAATGGCCGTCCGGGGAAGTAGTAACTATTACCTGATGAGCAAAATTC
AGCGCCGCCATTGGATCAAGCACGGCGAGACGGTGGGATTTGAAAAACAACAAGTTGAAGCAATGCTGGATGACATTATC
GGCCGGACACCAGAAGTGATTGAGCGTGTGAGTGCGTTGTTGCCGGAGGGGTTTCCGGTTGGGGTTGCGGAGAGAGTTTT
TGGGGGAATGAGAAAATTAAATCCAGTATTAACAAGAGGAGTGTGA
Antitoxin
Download Length: 83 a.a. Molecular weight: 9355.74 Da Isoelectric Point: 4.4665
>AT152360 WP_000581937.1 NZ_CP050173:1019275-1019523 [Escherichia coli]
MIHSSVKRWGNSPAVRIPATLMQALNLNIDDEVKIDLVDGKLIIEPVRKEPVFTLAELVNDITPENLHENIDWGEPKDKE
VW
MIHSSVKRWGNSPAVRIPATLMQALNLNIDDEVKIDLVDGKLIIEPVRKEPVFTLAELVNDITPENLHENIDWGEPKDKE
VW
Download Length: 249 bp
>AT152360 NZ_CP066129:c3784120-3783833 [Morganella morganii]
ATGAACACTGCTTATCCGCTTAAAACACTCAATCAGTTGCGTCCGTTGCTGGTCGGCTTTCGTAAGGCTAACGGAATGAC
GCAAAAAGACGTCTCAGAGAAACTCGGCGTTACGCAGCAGACCTATGCCCGCCTGGAAGCTAATCCGGCCAGTGCCAGTA
TTGAACGACTATTCAAAGTATTCACGGTGTTGGGTGTCGAAATGGTGCTTTCTGCCGGGCAATTCTCAGTTATTCGGGAA
TCTGCGGAAATACCGGATAATTCTCCGGCCAGACGGGAGAAATGGTAA
ATGAACACTGCTTATCCGCTTAAAACACTCAATCAGTTGCGTCCGTTGCTGGTCGGCTTTCGTAAGGCTAACGGAATGAC
GCAAAAAGACGTCTCAGAGAAACTCGGCGTTACGCAGCAGACCTATGCCCGCCTGGAAGCTAATCCGGCCAGTGCCAGTA
TTGAACGACTATTCAAAGTATTCACGGTGTTGGGTGTCGAAATGGTGCTTTCTGCCGGGCAATTCTCAGTTATTCGGGAA
TCTGCGGAAATACCGGATAATTCTCCGGCCAGACGGGAGAAATGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|