Detailed information of TA system TA152355

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 47736..48261
• Replicon: plasmid plas1
• Accession: NZ_CP050172
• Organism: Serratia fonticola strain CPSE11

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: -
• Locus tag: HAP32_RS25620
• Protein ID: WP_166735239.1
• Coordinates: 47956..48261 (+)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: A0A1Q5UXA6
• Locus tag: HAP32_RS25615
• Protein ID: WP_074032256.1
• Coordinates: 47736..47954 (+)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HAP32_RS25590	42890..43627	+	738	WP_166735236.1	type-F conjugative transfer system pilin acetylase TraX	-
HAP32_RS25595	43696..44412	+	717	WP_166735237.1	fertility inhibition protein FinO	-
HAP32_RS25600	44606..44910	+	305	Protein_46	phospholipase D family protein	-
HAP32_RS25605	45127..45378	+	252	WP_166735238.1	replication regulatory protein RepA	-
HAP32_RS25610	45810..46748	+	939	WP_166735284.1	Replication protein	-
HAP32_RS25615	47736..47954	+	219	WP_074032256.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
HAP32_RS25620	47956..48261	+	306	WP_166735239.1	type II toxin-antitoxin system toxin CcdB	Toxin
HAP32_RS25625	48418..49579	-	1162	Protein_51	IS91 family transposase	-
HAP32_RS25630	49906..52926	+	3021	WP_166735240.1	autotransporter serine protease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Mobilizable plasmid	-	-	1..122261	122261

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-100)

Antitoxin

• Post-segregation antitoxin CcdA (2-72)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 11412.14 Da
• Isoelectric Point: 6.9745

>T152355 WP_166735239.1 NZ_CP050172:47956-48261 [Serratia fonticola]
MQFTVYEYKRDSHYKLFVDVQSDIIETPGRRMVIPLLESRYFSQKVNRQLFPVVCVNGKDYRVMTTELSGVSASVTGAAL
ADVSADAEAIKNALNLMFWGI

Nucleotide

• Length: 306 bp

>T152355 NZ_CP066129:c482848-482594 [Morganella morganii]
ATGACATTGACGTTTTCGTCTCAGGCATGGGAAGACTATCTGTACTGGCAAAATACAGATAAAAAAACCCTCAGACGTAT
CAACGAATTAATTAAAGCTGCACAAAGAACGCCTTTCTCAGGTATAGGAAAGCCGGAACCACTGAAGAATAATCTCTCCG
GCTGGTGGTCGCGGCGAATAACAGAAGAACACCGGTTAGTTTACCGTGTCACTAACCAGGGTGTTGAGGTGGCGGCCTGC
CGGTATCATTACTGA

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 8170.03 Da
• Isoelectric Point: 6.6425

>AT152355 WP_074032256.1 NZ_CP050172:47736-47954 [Serratia fonticola]
MKHRVSVTVDKEHYQALHAAGVNISGLVNDAIGREARRIQAEHWKAENREGMEEVANFIAQHGSFADENRSW

Nucleotide

• Length: 219 bp

>AT152355 NZ_CP066129:c483096-482845 [Morganella morganii]
ATGAAAACATTAACATACAGTGAAGTACGGCAGAATCTCACCGCTGCGATGAATGAAACAGTGGATGACCGTATCCCTAT
TTTGATTACCCGGCAGAAAGGCACTGCATGTGTATTATTATCACTTGATGAATATCAGTCTCTGGAAGAGACCGCCTATT
TAATGCGTTCACCTAATAACGCGCGACGTTTAATGGATTCCATTGATGAATTGAATGCCGGCAAGGGACTCAAAAAGGAA
ATCAATGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A1Q5UXA6