Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 5848..6367 Replicon plasmid plas1
Accession NZ_CP050172
Organism Serratia fonticola strain CPSE11

Toxin (Protein)


Gene name relE Uniprot ID A0A7Y9C104
Locus tag HAP32_RS25415 Protein ID WP_037376617.1
Coordinates 5848..6135 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D4E9W7
Locus tag HAP32_RS25420 Protein ID WP_004966044.1
Coordinates 6125..6367 (-) Length 81 a.a.

Genomic Context

HAP32_RS25385HAP32_RS25390HAP32_RS25425HAP32_RS25430HAP32_RS25435HAP32_RS25440HAP32_RS25380HAP32_RS25395HAP32_RS25400HAP32_RS25405HAP32_RS25410HAP32_RS25415HAP32_RS25420
Location: 3128..3412 (285 bp)
Type: Others
Protein ID: WP_166735208.1
Location: 3409..4212 (804 bp)
Type: Others
Protein ID: WP_166735280.1
Location: 6684..7877 (1194 bp)
Type: Others
Protein ID: WP_166735281.1
Location: 7886..8857 (972 bp)
Type: Others
Protein ID: WP_166735212.1
Location: 9924..10475 (552 bp)
Type: Others
Protein ID: WP_166735213.1
Location: 10453..10767 (315 bp)
Type: Others
Protein ID: WP_166735214.1
Location: 1665..2360 (696 bp)
Type: Others
Protein ID: Protein_2
Location: 4279..4626 (348 bp)
Type: Others
Protein ID: WP_166735209.1
Location: 4610..4879 (270 bp)
Type: Others
Protein ID: WP_161713053.1
Location: 5038..5244 (207 bp)
Type: Others
Protein ID: WP_166735210.1
Location: 5432..5530 (99 bp)
Type: Others
Protein ID: WP_166735211.1
Location: 5848..6135 (288 bp)
Type: Toxin
Protein ID: WP_037376617.1
Location: 6125..6367 (243 bp)
Type: Antitoxin
Protein ID: WP_004966044.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HAP32_RS253801665..2360-696Protein_2IS6 family transposase-
HAP32_RS253853128..3412+285WP_166735208.1hypothetical protein-
HAP32_RS253903409..4212+804WP_166735280.1tyrosine-type recombinase/integrase-
HAP32_RS253954279..4626-348WP_166735209.1type II toxin-antitoxin system RelE/ParE family toxin-
HAP32_RS254004610..4879-270WP_161713053.1hypothetical protein-
HAP32_RS254055038..5244-207WP_166735210.1transposase-
HAP32_RS254105432..5530-99WP_166735211.1transposase-
HAP32_RS254155848..6135-288WP_037376617.1type II toxin-antitoxin system RelE/ParE family toxinToxin
HAP32_RS254206125..6367-243WP_004966044.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
HAP32_RS254256684..7877+1194WP_166735281.1AAA family ATPase-
HAP32_RS254307886..8857+972WP_166735212.1ParB/RepB/Spo0J family partition protein-
HAP32_RS254359924..10475+552WP_166735213.1single-stranded DNA-binding protein-
HAP32_RS2544010453..10767+315WP_166735214.1DUF905 family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideMobilizable plasmid--1..122261122261


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(2-72)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10993.95 Da        Isoelectric Point: 10.3023

>T152354 WP_037376617.1 NZ_CP050172:c6135-5848 [Serratia fonticola]
MTYKIDFDNAAFKEWKKLGETVRQQLKKKLAQIVEAPRIEANRLHSLPDCYKIKLRASGYRLVYKVEDETVVILVLAVGK
RERLEVYKAAATRLG

Download         Length: 288 bp

>T152354 NZ_CP066127:3305342-3305545 [Morganella morganii]
ATGACTAAACTTGACTATCTCATGCGCTTACGTAAGTGCACTTCGATCGAAACACTGGAACGTGTCATTGAGAAGAACAA
ATATGAACTGACTGATGACGAGCTGGAGGTTTTTTATTCAGCTGCCGATCATCGTCTGGCCGAATTAACCATGAATAAAC
TGTATGACAAAATCCCGGCGTCTGTCTGGAAATTTGTCCGTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8744.06 Da        Isoelectric Point: 4.3951

>AT152354 WP_004966044.1 NZ_CP050172:c6367-6125 [Serratia fonticola]
MGTMNIRIDDDLKARAGVALDGLGITASEAVRMVLEYVAQNNRLPVQVALLADEDADIIELARERLANPGKRIRVTLDDL

Download         Length: 243 bp

>AT152354 NZ_CP066127:3304920-3305279 [Morganella morganii]
ATGGACGAGTATTCTCCACGAAATTACGATATTGCGGTACTGAAGTATCTGTGTGATGAACTTTGCCGTGAAGGCACACA
AACTCTCATCAGAAGCAATAATTTTTGGGTTAATGATTTAGCCTCAGATTCAAACTTAAAACTTAACGAATTATTAGGTT
ACATTGCTGACGTGACCTGGAGTTTTAAGATAAAACATACACAAAATAAGGATCTCATCTCATTTGTCGATGAATACATC
GATGAAACTTACGCGCTGTTTGGTCAGATGGAAGTTTCATTTAATGATGTTGAGGAATGGAAGAAGATGGCATCACTGGT
AAGCAGCATGCTGACCAGCGAAGGGCATCTGGTCCACTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A7Y9C104

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A7Y9C138

References