Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 5848..6367 Replicon plasmid plas1
Accession NZ_CP050172
Organism Serratia fonticola strain CPSE11

Toxin (Protein)


Gene name relE Uniprot ID A0A7Y9C104
Locus tag HAP32_RS25415 Protein ID WP_037376617.1
Coordinates 5848..6135 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D4E9W7
Locus tag HAP32_RS25420 Protein ID WP_004966044.1
Coordinates 6125..6367 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HAP32_RS25380 1665..2360 - 696 Protein_2 IS6 family transposase -
HAP32_RS25385 3128..3412 + 285 WP_166735208.1 hypothetical protein -
HAP32_RS25390 3409..4212 + 804 WP_166735280.1 tyrosine-type recombinase/integrase -
HAP32_RS25395 4279..4626 - 348 WP_166735209.1 type II toxin-antitoxin system RelE/ParE family toxin -
HAP32_RS25400 4610..4879 - 270 WP_161713053.1 hypothetical protein -
HAP32_RS25405 5038..5244 - 207 WP_166735210.1 transposase -
HAP32_RS25410 5432..5530 - 99 WP_166735211.1 transposase -
HAP32_RS25415 5848..6135 - 288 WP_037376617.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HAP32_RS25420 6125..6367 - 243 WP_004966044.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HAP32_RS25425 6684..7877 + 1194 WP_166735281.1 AAA family ATPase -
HAP32_RS25430 7886..8857 + 972 WP_166735212.1 ParB/RepB/Spo0J family partition protein -
HAP32_RS25435 9924..10475 + 552 WP_166735213.1 single-stranded DNA-binding protein -
HAP32_RS25440 10453..10767 + 315 WP_166735214.1 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..122261 122261


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(2-72)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10993.95 Da        Isoelectric Point: 10.3023

>T152354 WP_037376617.1 NZ_CP050172:c6135-5848 [Serratia fonticola]
MTYKIDFDNAAFKEWKKLGETVRQQLKKKLAQIVEAPRIEANRLHSLPDCYKIKLRASGYRLVYKVEDETVVILVLAVGK
RERLEVYKAAATRLG

Download         Length: 288 bp

>T152354 NZ_CP066127:3305342-3305545 [Morganella morganii]
ATGACTAAACTTGACTATCTCATGCGCTTACGTAAGTGCACTTCGATCGAAACACTGGAACGTGTCATTGAGAAGAACAA
ATATGAACTGACTGATGACGAGCTGGAGGTTTTTTATTCAGCTGCCGATCATCGTCTGGCCGAATTAACCATGAATAAAC
TGTATGACAAAATCCCGGCGTCTGTCTGGAAATTTGTCCGTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8744.06 Da        Isoelectric Point: 4.3951

>AT152354 WP_004966044.1 NZ_CP050172:c6367-6125 [Serratia fonticola]
MGTMNIRIDDDLKARAGVALDGLGITASEAVRMVLEYVAQNNRLPVQVALLADEDADIIELARERLANPGKRIRVTLDDL

Download         Length: 243 bp

>AT152354 NZ_CP066127:3304920-3305279 [Morganella morganii]
ATGGACGAGTATTCTCCACGAAATTACGATATTGCGGTACTGAAGTATCTGTGTGATGAACTTTGCCGTGAAGGCACACA
AACTCTCATCAGAAGCAATAATTTTTGGGTTAATGATTTAGCCTCAGATTCAAACTTAAAACTTAACGAATTATTAGGTT
ACATTGCTGACGTGACCTGGAGTTTTAAGATAAAACATACACAAAATAAGGATCTCATCTCATTTGTCGATGAATACATC
GATGAAACTTACGCGCTGTTTGGTCAGATGGAAGTTTCATTTAATGATGTTGAGGAATGGAAGAAGATGGCATCACTGGT
AAGCAGCATGCTGACCAGCGAAGGGCATCTGGTCCACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Y9C104

Antitoxin

Source ID Structure
AlphaFold DB A0A7Y9C138

References