Detailed information of TA system TA152353

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 3982281..3982903
• Replicon: chromosome
• Accession: NZ_CP050171
• Organism: Serratia fonticola strain CPSE11

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: U2M374
• Locus tag: HAP32_RS18355
• Protein ID: WP_021180142.1
• Coordinates: 3982281..3982484 (-)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: U2NAN4
• Locus tag: HAP32_RS18360
• Protein ID: WP_021180141.1
• Coordinates: 3982535..3982903 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HAP32_RS18330	3978086..3978574	+	489	WP_021180151.1	YbaY family lipoprotein	-
HAP32_RS18335	3978629..3978943	-	315	WP_021180150.1	MGMT family protein	-
HAP32_RS18345	3979349..3981136	-	1788	WP_166734311.1	amidohydrolase family protein	-
HAP32_RS18350	3981273..3982199	+	927	WP_024484393.1	LysR family transcriptional regulator	-
HAP32_RS18355	3982281..3982484	-	204	WP_021180142.1	hemolysin expression modulator Hha	Toxin
HAP32_RS18360	3982535..3982903	-	369	WP_021180141.1	Hha toxicity modulator TomB	Antitoxin
HAP32_RS18365	3983061..3983414	-	354	WP_166735153.1	hypothetical protein	-
HAP32_RS18370	3983794..3984486	+	693	WP_166734312.1	ABC transporter ATP-binding protein	-
HAP32_RS18375	3984486..3985343	+	858	WP_166734313.1	metal ABC transporter permease	-
HAP32_RS18380	3985369..3986247	+	879	WP_115158625.1	zinc ABC transporter substrate-binding protein	-
HAP32_RS18385	3986355..3986495	-	141	WP_115158626.1	type B 50S ribosomal protein L36	-
HAP32_RS18390	3986508..3986765	-	258	WP_021180135.1	type B 50S ribosomal protein L31	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (8-64)

Antitoxin

• Biofilm formation regulator YbaJ (1-118)

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 8099.48 Da
• Isoelectric Point: 6.9770

>T152353 WP_021180142.1 NZ_CP050171:c3982484-3982281 [Serratia fonticola]
MTKIDYLMRLRKCTTIETLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPVAVWKFVR

Nucleotide

• Length: 204 bp

>T152353 NZ_CP066127:2134399-2134743 [Morganella morganii]
GTGTGGACAGTATTATTAACGGATTATTTTAATGAATGGTTGTCAAAACAAGATACCCGGATGAAAGAAAAAGTGCTCGC
ATCTCTTGGCAATCTTGAAATTTATGGCCCTGTTCTGACAAGACCTTATGTTGATACAGTTAAAACTTCTCAGTACCCGA
ATATGAAAGAATTGAGAATTTGGCATGCTGGTCGTGCAATACGTGCATTTTTTGCCTTTGATCCTGAAAGGCAGGCCATT
ATTTTATGTGCCGGAGATAAAGGGAAGGATAAACGATTTTATCAGACGATGATTCGTATTGCGGACGAACAATTTTCCTC
ATATCTTTCAGCAACGCAGGAATAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 14097.78 Da
• Isoelectric Point: 4.5140

>AT152353 WP_021180141.1 NZ_CP050171:c3982903-3982535 [Serratia fonticola]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSAVNLQLNELIEHIASFVMSFKIKYMDEGDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARTFRLFSGEGVCTTMKT

Nucleotide

• Length: 369 bp

>AT152353 NZ_CP066127:2134748-2135047 [Morganella morganii]
ATGAAAACATTACAGGAAGTGATAGCGGCTCAATCACCGGAGAGCCGTGAGCGGATAAAACAACTGACTGATGAGCTGGT
TCTTGAAACCGGACTGCAACTTCTCAGAGAAGAACTTCATATCTCTCAGAAAACGCTGGCAAATAATCTTGGTATATCAC
AGCCGGCTGTTACTCAGATTGAGCAGCGCGGTAATGATATCAAACTGGCAACGCTGAAACGCTATATTGAGGCAATGGGC
GGAACACTTCGTCTGACGATTGAACTACCGACCGGTGATAACCGGATTTTTCGTGTCTGA

Structures

Toxin

• AlphaFold DB: U2M374

Antitoxin

• AlphaFold DB: U2NAN4