Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3982281..3982903 Replicon chromosome
Accession NZ_CP050171
Organism Serratia fonticola strain CPSE11

Toxin (Protein)


Gene name Hha Uniprot ID U2M374
Locus tag HAP32_RS18355 Protein ID WP_021180142.1
Coordinates 3982281..3982484 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID U2NAN4
Locus tag HAP32_RS18360 Protein ID WP_021180141.1
Coordinates 3982535..3982903 (-) Length 123 a.a.

Genomic Context

HAP32_RS18330HAP32_RS18350HAP32_RS18370HAP32_RS18375HAP32_RS18380HAP32_RS18335HAP32_RS18345HAP32_RS18355HAP32_RS18360HAP32_RS18365HAP32_RS18385HAP32_RS18390
Location: 3978086..3978574 (489 bp)
Type: Others
Protein ID: WP_021180151.1
Location: 3981273..3982199 (927 bp)
Type: Others
Protein ID: WP_024484393.1
Location: 3983794..3984486 (693 bp)
Type: Others
Protein ID: WP_166734312.1
Location: 3984486..3985343 (858 bp)
Type: Others
Protein ID: WP_166734313.1
Location: 3985369..3986247 (879 bp)
Type: Others
Protein ID: WP_115158625.1
Location: 3978629..3978943 (315 bp)
Type: Others
Protein ID: WP_021180150.1
Location: 3979349..3981136 (1788 bp)
Type: Others
Protein ID: WP_166734311.1
Location: 3982281..3982484 (204 bp)
Type: Toxin
Protein ID: WP_021180142.1
Location: 3982535..3982903 (369 bp)
Type: Antitoxin
Protein ID: WP_021180141.1
Location: 3983061..3983414 (354 bp)
Type: Others
Protein ID: WP_166735153.1
Location: 3986355..3986495 (141 bp)
Type: Others
Protein ID: WP_115158626.1
Location: 3986508..3986765 (258 bp)
Type: Others
Protein ID: WP_021180135.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HAP32_RS183303978086..3978574+489WP_021180151.1YbaY family lipoprotein-
HAP32_RS183353978629..3978943-315WP_021180150.1MGMT family protein-
HAP32_RS183453979349..3981136-1788WP_166734311.1amidohydrolase family protein-
HAP32_RS183503981273..3982199+927WP_024484393.1LysR family transcriptional regulator-
HAP32_RS183553982281..3982484-204WP_021180142.1hemolysin expression modulator HhaToxin
HAP32_RS183603982535..3982903-369WP_021180141.1Hha toxicity modulator TomBAntitoxin
HAP32_RS183653983061..3983414-354WP_166735153.1hypothetical protein-
HAP32_RS183703983794..3984486+693WP_166734312.1ABC transporter ATP-binding protein-
HAP32_RS183753984486..3985343+858WP_166734313.1metal ABC transporter permease-
HAP32_RS183803985369..3986247+879WP_115158625.1zinc ABC transporter substrate-binding protein-
HAP32_RS183853986355..3986495-141WP_115158626.1type B 50S ribosomal protein L36-
HAP32_RS183903986508..3986765-258WP_021180135.1type B 50S ribosomal protein L31-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8099.48 Da        Isoelectric Point: 6.9770

>T152353 WP_021180142.1 NZ_CP050171:c3982484-3982281 [Serratia fonticola]
MTKIDYLMRLRKCTTIETLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPVAVWKFVR

Download         Length: 204 bp

>T152353 NZ_CP066127:2134399-2134743 [Morganella morganii]
GTGTGGACAGTATTATTAACGGATTATTTTAATGAATGGTTGTCAAAACAAGATACCCGGATGAAAGAAAAAGTGCTCGC
ATCTCTTGGCAATCTTGAAATTTATGGCCCTGTTCTGACAAGACCTTATGTTGATACAGTTAAAACTTCTCAGTACCCGA
ATATGAAAGAATTGAGAATTTGGCATGCTGGTCGTGCAATACGTGCATTTTTTGCCTTTGATCCTGAAAGGCAGGCCATT
ATTTTATGTGCCGGAGATAAAGGGAAGGATAAACGATTTTATCAGACGATGATTCGTATTGCGGACGAACAATTTTCCTC
ATATCTTTCAGCAACGCAGGAATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14097.78 Da        Isoelectric Point: 4.5140

>AT152353 WP_021180141.1 NZ_CP050171:c3982903-3982535 [Serratia fonticola]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSAVNLQLNELIEHIASFVMSFKIKYMDEGDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARTFRLFSGEGVCTTMKT

Download         Length: 369 bp

>AT152353 NZ_CP066127:2134748-2135047 [Morganella morganii]
ATGAAAACATTACAGGAAGTGATAGCGGCTCAATCACCGGAGAGCCGTGAGCGGATAAAACAACTGACTGATGAGCTGGT
TCTTGAAACCGGACTGCAACTTCTCAGAGAAGAACTTCATATCTCTCAGAAAACGCTGGCAAATAATCTTGGTATATCAC
AGCCGGCTGTTACTCAGATTGAGCAGCGCGGTAATGATATCAAACTGGCAACGCTGAAACGCTATATTGAGGCAATGGGC
GGAACACTTCGTCTGACGATTGAACTACCGACCGGTGATAACCGGATTTTTCGTGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBU2M374

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBU2NAN4

References