Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 3270466..3271028 Replicon chromosome
Accession NZ_CP050171
Organism Serratia fonticola strain CPSE11

Toxin (Protein)


Gene name ccdB Uniprot ID A0A4P8TYM9
Locus tag HAP32_RS15180 Protein ID WP_071681289.1
Coordinates 3270466..3270783 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A0F7D1U7
Locus tag HAP32_RS15185 Protein ID WP_024486363.1
Coordinates 3270783..3271028 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HAP32_RS15165 3266162..3267256 + 1095 WP_166733989.1 LPS export ABC transporter permease LptF -
HAP32_RS15170 3267256..3268326 + 1071 WP_021807815.1 LPS export ABC transporter permease LptG -
HAP32_RS15175 3268428..3270224 - 1797 WP_166733990.1 polygalacturonase -
HAP32_RS15180 3270466..3270783 - 318 WP_071681289.1 CcdB family protein Toxin
HAP32_RS15185 3270783..3271028 - 246 WP_024486363.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
HAP32_RS15190 3271118..3271447 - 330 WP_021179117.1 multidrug efflux SMR transporter -
HAP32_RS15195 3271459..3271818 - 360 WP_024529409.1 multidrug efflux SMR transporter -
HAP32_RS15200 3272327..3272995 - 669 WP_166733991.1 hypothetical protein -
HAP32_RS15205 3273006..3273641 - 636 WP_166733992.1 phosphate propanoyltransferase -
HAP32_RS15210 3273677..3274111 - 435 WP_166733993.1 BMC domain-containing protein -
HAP32_RS15215 3274122..3275072 - 951 WP_166733994.1 choline TMA-lyase-activating enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(3-104)

Antitoxin

Post-segregation antitoxin CcdA

(9-75)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11695.64 Da        Isoelectric Point: 8.0501

>T152352 WP_071681289.1 NZ_CP050171:c3270783-3270466 [Serratia fonticola]
MKQFSVYKNQSKNKKNYPFFIVVQSDLLDHLSTRLVMPLALKHATNSQVKALTPVLSVDQQDYVILTSLLTTTDVKNLNA
DCLVTNAAHLRDELVAAIDLLVLGI

Download         Length: 318 bp

>T152352 NZ_CP066127:1689324-1689677 [Morganella morganii]
GTGTGGAAGATAATTACAACAGATAATTTTGCAGCGTGGTTTGCTGCGCAGGATGACGGGGATCGTACAGCAATACTGGC
AGCGATGCTGGTATTGGAGAAGACCGGACCCGGTTTATCAGGACCGTATGCGGATACTGTGAAAGGTTCGCGTTATACGA
ATATGAAAGAGTTACGTATACAAAGCAGAGGGCAGCCGATAAGGGCATTTTTTGCATTCGACCCTGAACGGAGAGGTGTT
TTGCTGTGCGCAGGGTATAAAACCGGCAAAGAAAAACGTTTTTATATGCAGATGATTCCGCAGGCTGACCGTGAGTATAC
AGAATGGCTGAACAGGCCGGAAAACAGGAGTTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8941.18 Da        Isoelectric Point: 5.0644

>AT152352 WP_024486363.1 NZ_CP050171:c3271028-3270783 [Serratia fonticola]
MGAVSVIKKRNTNVYLRVDLIEQAKALDLNLSATLNHALELAVKKGQRERWLAENRAGLEALNGFVEENGLFSDDADFGV
L

Download         Length: 246 bp

>AT152352 NZ_CP066127:1689680-1689982 [Morganella morganii]
ATGGGAAAGTCACTCAGACAACTGCTGGCTGAGGAAAAGCCGGAAGTCGCGGCAGCAGCACGGGTTCAGGCGGACGAGAT
CCTGCTGAATATCCATCTGGCGGAACTGCGGGAGAAAGTGAACAAAACACAGGTGGAAATGGCACAGGCGCTGGGGATCA
AGCAGCCGACGGTCGCCGGGATGGAAAAACCGGGGCGTGATGTCAAATTATCCACGCTGAGACGCTATGTGGACGCCATC
GGCGGAAAACTGAATATTGATGTTGAGCTGCCGGACGGCACGCATTATATGTTCAGGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P8TYM9

Antitoxin

Source ID Structure
AlphaFold DB A0A0F7D1U7

References