Detailed information of TA system TA152349

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2647773..2649352
• Replicon: chromosome
• Accession: NZ_CP050171
• Organism: Serratia fonticola strain CPSE11

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: HAP32_RS12285
• Protein ID: WP_166733741.1
• Coordinates: 2647773..2649092 (-)
• Length: 440 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: HAP32_RS12290
• Protein ID: WP_059199269.1
• Coordinates: 2649092..2649352 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HAP32_RS12265	2643490..2644827	+	1338	WP_059199273.1	NCS2 family permease	-
HAP32_RS12270	2644882..2645934	-	1053	WP_071682669.1	hypothetical protein	-
HAP32_RS12275	2646027..2646593	-	567	WP_071682670.1	NAD(P)H-dependent oxidoreductase	-
HAP32_RS12280	2646782..2647501	-	720	WP_059199271.1	4'-phosphopantetheinyl transferase superfamily protein	-
HAP32_RS12285	2647773..2649092	-	1320	WP_166733741.1	type II toxin-antitoxin system HipA family toxin	Toxin
HAP32_RS12290	2649092..2649352	-	261	WP_059199269.1	helix-turn-helix domain-containing protein	Antitoxin
HAP32_RS12295	2649664..2651028	-	1365	WP_059199268.1	tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE	-
HAP32_RS12300	2651142..2652782	-	1641	WP_021181397.1	membrane protein insertase YidC	-
HAP32_RS12305	2652785..2653042	-	258	WP_025120915.1	membrane protein insertion efficiency factor YidD	-
HAP32_RS12310	2653006..2653365	-	360	WP_004950547.1	ribonuclease P protein component	-
HAP32_RS12315	2653384..2653524	-	141	WP_004093983.1	50S ribosomal protein L34	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 440 a.a.
• Molecular weight: 48791.06 Da
• Isoelectric Point: 7.1489

>T152349 WP_166733741.1 NZ_CP050171:c2649092-2647773 [Serratia fonticola]
MADLDVYMNGYKVGIFSREGTGAHMFQYVDTWLNQPGSRPISLSMPLRRRPYKGAEVYNFFDNLLPDNPEIRGRILARYR
ADSTQPFDLLARIGADTIGALQLLPQNAGPGDIRTINYKALSNQELASILTGYKAGAPLGMIEDVEDFRISLAGAQEKTA
LLYLENRWCLPIAATPTTHIIKLPIGKIESHSNSIDLSDSVENEYLCALVAKEFGLSVPHCFIMQVGDIKALAVERFDRR
YASDGSWIMRLPQEDFCQVLNVPSARKYENQGGPGISEIMEYLLGSVTAEKDRYNFMKTQVLFWLLAATDGHAKNFSVFI
EADGRFRLTPLYDILSVYPEFGGRGLHPKDAKLAMGLKGSKGKKYAIDQIFPRHFFHTAKAVGFERAAMEGILTELAESV
DTVIERVTQLLPAGFPPAISNAILKGLKARSARLTVGWD

Nucleotide

• Length: 1320 bp

>T152349 NZ_CP066126:1499483-1499665 [Chromobacterium rhizoryzae]
GTGACCAGCAAAGAAGTCATCAGCATGATAGAGGCCGACGGCTGGTATCTGGTTGCCGCCAAGGGCAGCCATCAACAGTT
CAAACACCCGATCAAGACCGGCCGGGTGACGGTGCCTCACCCCAAGAAGGACATACCGATAGGCACGCTGAACAGTATCA
AGAAACAAGCGGGTCTCAAGTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9832.18 Da
• Isoelectric Point: 6.3263

>AT152349 WP_059199269.1 NZ_CP050171:c2649352-2649092 [Serratia fonticola]
MKITNAKQLSIYLRDVRLAENLSQEKVASRVGIRQDTVSNFELQPGTTKLETFFKILSALDLELEVKPRGSQSCETKSTD
GWKEEW

Nucleotide

• Length: 261 bp

>AT152349 NZ_CP066126:1499675-1500085 [Chromobacterium rhizoryzae]
ATGTACTACCCGATTGCAGTTGAACCCGGTGACGACCAACATGCCTACGGCGTCATCGTGCCGGATCTGCCCGGCTGCTT
CTCCGCCGGGGACACTCTGGATGAGGCCATCCGGAACGCCCGCGAAGCCATTGAGCTACATCTGGAAGGGCTGGTGGAAG
ACCTGGACGTCATCCCTCTGGCCAGCAGCGCGCAGGCTCATGTCGGTAAATCTGAGTTTGCCGGCCATCTCTGGGCGCTG
GTGGATGTGGACATCACCCGCTATCTGGGTAAAGCGACCAAGATCAATGTCACGTTGCCGGCCAACCTTCTGCACCGTAT
CGATGAATATGTCGCTTCCCACCCGGAATACGATAGCCGTAGCGGTTTCCTGGCCAAGACCGCGCTAGAAAAGCTGTTGT
GTCGGCCGTAA