Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2647773..2649352 Replicon chromosome
Accession NZ_CP050171
Organism Serratia fonticola strain CPSE11

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag HAP32_RS12285 Protein ID WP_166733741.1
Coordinates 2647773..2649092 (-) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag HAP32_RS12290 Protein ID WP_059199269.1
Coordinates 2649092..2649352 (-) Length 87 a.a.

Genomic Context

HAP32_RS12265HAP32_RS12270HAP32_RS12275HAP32_RS12280HAP32_RS12285HAP32_RS12290HAP32_RS12295HAP32_RS12300HAP32_RS12305HAP32_RS12310HAP32_RS12315
Location: 2643490..2644827 (1338 bp)
Type: Others
Protein ID: WP_059199273.1
Location: 2644882..2645934 (1053 bp)
Type: Others
Protein ID: WP_071682669.1
Location: 2646027..2646593 (567 bp)
Type: Others
Protein ID: WP_071682670.1
Location: 2646782..2647501 (720 bp)
Type: Others
Protein ID: WP_059199271.1
Location: 2647773..2649092 (1320 bp)
Type: Toxin
Protein ID: WP_166733741.1
Location: 2649092..2649352 (261 bp)
Type: Antitoxin
Protein ID: WP_059199269.1
Location: 2649664..2651028 (1365 bp)
Type: Others
Protein ID: WP_059199268.1
Location: 2651142..2652782 (1641 bp)
Type: Others
Protein ID: WP_021181397.1
Location: 2652785..2653042 (258 bp)
Type: Others
Protein ID: WP_025120915.1
Location: 2653006..2653365 (360 bp)
Type: Others
Protein ID: WP_004950547.1
Location: 2653384..2653524 (141 bp)
Type: Others
Protein ID: WP_004093983.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HAP32_RS122652643490..2644827+1338WP_059199273.1NCS2 family permease-
HAP32_RS122702644882..2645934-1053WP_071682669.1hypothetical protein-
HAP32_RS122752646027..2646593-567WP_071682670.1NAD(P)H-dependent oxidoreductase-
HAP32_RS122802646782..2647501-720WP_059199271.14'-phosphopantetheinyl transferase superfamily protein-
HAP32_RS122852647773..2649092-1320WP_166733741.1type II toxin-antitoxin system HipA family toxinToxin
HAP32_RS122902649092..2649352-261WP_059199269.1helix-turn-helix domain-containing proteinAntitoxin
HAP32_RS122952649664..2651028-1365WP_059199268.1tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE-
HAP32_RS123002651142..2652782-1641WP_021181397.1membrane protein insertase YidC-
HAP32_RS123052652785..2653042-258WP_025120915.1membrane protein insertion efficiency factor YidD-
HAP32_RS123102653006..2653365-360WP_004950547.1ribonuclease P protein component-
HAP32_RS123152653384..2653524-141WP_004093983.150S ribosomal protein L34-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 48791.06 Da        Isoelectric Point: 7.1489

>T152349 WP_166733741.1 NZ_CP050171:c2649092-2647773 [Serratia fonticola]
MADLDVYMNGYKVGIFSREGTGAHMFQYVDTWLNQPGSRPISLSMPLRRRPYKGAEVYNFFDNLLPDNPEIRGRILARYR
ADSTQPFDLLARIGADTIGALQLLPQNAGPGDIRTINYKALSNQELASILTGYKAGAPLGMIEDVEDFRISLAGAQEKTA
LLYLENRWCLPIAATPTTHIIKLPIGKIESHSNSIDLSDSVENEYLCALVAKEFGLSVPHCFIMQVGDIKALAVERFDRR
YASDGSWIMRLPQEDFCQVLNVPSARKYENQGGPGISEIMEYLLGSVTAEKDRYNFMKTQVLFWLLAATDGHAKNFSVFI
EADGRFRLTPLYDILSVYPEFGGRGLHPKDAKLAMGLKGSKGKKYAIDQIFPRHFFHTAKAVGFERAAMEGILTELAESV
DTVIERVTQLLPAGFPPAISNAILKGLKARSARLTVGWD

Download         Length: 1320 bp

>T152349 NZ_CP066126:1499483-1499665 [Chromobacterium rhizoryzae]
GTGACCAGCAAAGAAGTCATCAGCATGATAGAGGCCGACGGCTGGTATCTGGTTGCCGCCAAGGGCAGCCATCAACAGTT
CAAACACCCGATCAAGACCGGCCGGGTGACGGTGCCTCACCCCAAGAAGGACATACCGATAGGCACGCTGAACAGTATCA
AGAAACAAGCGGGTCTCAAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9832.18 Da        Isoelectric Point: 6.3263

>AT152349 WP_059199269.1 NZ_CP050171:c2649352-2649092 [Serratia fonticola]
MKITNAKQLSIYLRDVRLAENLSQEKVASRVGIRQDTVSNFELQPGTTKLETFFKILSALDLELEVKPRGSQSCETKSTD
GWKEEW

Download         Length: 261 bp

>AT152349 NZ_CP066126:1499675-1500085 [Chromobacterium rhizoryzae]
ATGTACTACCCGATTGCAGTTGAACCCGGTGACGACCAACATGCCTACGGCGTCATCGTGCCGGATCTGCCCGGCTGCTT
CTCCGCCGGGGACACTCTGGATGAGGCCATCCGGAACGCCCGCGAAGCCATTGAGCTACATCTGGAAGGGCTGGTGGAAG
ACCTGGACGTCATCCCTCTGGCCAGCAGCGCGCAGGCTCATGTCGGTAAATCTGAGTTTGCCGGCCATCTCTGGGCGCTG
GTGGATGTGGACATCACCCGCTATCTGGGTAAAGCGACCAAGATCAATGTCACGTTGCCGGCCAACCTTCTGCACCGTAT
CGATGAATATGTCGCTTCCCACCCGGAATACGATAGCCGTAGCGGTTTCCTGGCCAAGACCGCGCTAGAAAAGCTGTTGT
GTCGGCCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References