Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 2350888..2351531 Replicon chromosome
Accession NZ_CP050171
Organism Serratia fonticola strain CPSE11

Toxin (Protein)


Gene name vagD Uniprot ID U2MXY5
Locus tag HAP32_RS10965 Protein ID WP_021181796.1
Coordinates 2351115..2351531 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A7Y8XMD5
Locus tag HAP32_RS10960 Protein ID WP_039996188.1
Coordinates 2350888..2351118 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HAP32_RS10940 2347293..2347388 + 96 WP_173410098.1 protein MgtS -
HAP32_RS10945 2347388..2347555 + 168 WP_155621695.1 hypothetical protein -
HAP32_RS10950 2347705..2349069 + 1365 WP_166733630.1 cation-efflux pump -
HAP32_RS10955 2349147..2350487 - 1341 WP_166733631.1 amidohydrolase family protein -
HAP32_RS10960 2350888..2351118 + 231 WP_039996188.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HAP32_RS10965 2351115..2351531 + 417 WP_021181796.1 type II toxin-antitoxin system VapC family toxin Toxin
HAP32_RS10970 2351834..2353381 + 1548 WP_166733632.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15043.34 Da        Isoelectric Point: 7.8858

>T152348 WP_021181796.1 NZ_CP050171:2351115-2351531 [Serratia fonticola]
VNKTYMLDTNICSFIMREQPEAVIKRLEQAVLRNHRIVVSAITYAEMRFGAIGKKASPRHAQLVDAFCARLDAVLAWDRA
AVDATTEVKAALSAAGTPIGPNDTAIAGHAIAADAILVTNNTREFARVPDLKLEDWVK

Download         Length: 417 bp

>T152348 NZ_CP066125:c4991009-4989690 [Aeromonas veronii]
ATGGCCAATCTGGCTGTCTACATGAACGGCTATCGGGTAGGCACATTCACCAAAACTACCAGCGGTGCCCATCAGTTTCA
GTACCATGAATCATGGCTAGCACAATCGGGCAGCCGTCCGATCTCACTCTCCATGCCATTGCGCCATCAGGCCTACCGGG
GCGATGAAGCCTATAACTTCTTCGACAACCTGCTGCCAGATAATACGGAGGTGAGGAACAGGGTTGTAGCACGCTATCAA
GCGGCATCAACTCAGCCCTTCGATCTGCTCAGTTGCATTGGCCAGGATAGCGTAGGGGCATTACAGCTGGTTACCGAAGG
GCACGACGTTCCAGATGTCAGGCGAATCGACTACAAAGCACTTTCCGATGGCGAGCTCGAGCAGATCCTGACCAGCTACA
AATCAGGAATCCCTTTGGGGATGGTCAGAGAGCAAGAGGAGTTCCGGATCTCTATCGCCGGAGCGCAAGAAAAGACAGCG
CTGCTCTATCTCGATGGCCGTTGGTACTTGCCACTCAACGCAACGCCGACAACCCACATTATCAAACTCCCTATTGGCAA
GATTGAAAGCCACTCCTACTCGATAGACCTCTCCCAGAGCGTAGAAAACGAATATCTCTGCACTCTGATTGCCAAGGAGT
TTGGTCTACCCGTACCTCACTGCTTCATGATGCAGGTTGGCCAGGTCAAAGCACTGGCTGTGGAACGCTTCGACAGACGT
TACGCTGCCGATCGCAGTTGGATCATGCGCCTTCCCCAAGAAGATTTCTGTCAGGTATTGAATGTTCCGTCAGCACGGAA
ATACGAGAGTCATGGAGGACCAGGGATCACTGACATCATGAAAACCTTGCTGGGCTCTGCGACACCAGAACAGGATCGCT
ACCTGTTCATGAAATCTCAGGTCCTGTTCTGGCTGCTGGCAGCCACCGATGGCCATGCAAAGAACTTCTCGGTCTTTATT
GAACCGGAAGGGCGTTTTCGCCTGACCCCTTTTTACGACATCCTATCTGTCTATCCAGTGTTTGGCGGCCGAGGCCTCAA
CCGAAGGGACGCCAAGCTCGCTATGGGCCTAGCAAGCAGCAAGGGAAAGAAATACGCCATTGAGCAGATATTCCCGCGTC
ATTTCTTCCAAACGGCAAAAGCTGTGGGATTTGAGCGTTCTGCTATGGAAGAGATCCTGACAGAACTGGCCAACTCCGTT
GATGATGTTATTGAGCGTGTTACCCAGCAATTGCCAGCGGGCTTCCCCGATGCCATCAGCAGCACCATTCTAGAGGGCCT
AAAAGCCCGCTCAGCCAGGCTGATAAAGGGCTGGGATTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8858.98 Da        Isoelectric Point: 4.4992

>AT152348 WP_039996188.1 NZ_CP050171:2350888-2351118 [Serratia fonticola]
MRTVSIFKNGNNRAIRLPRDMDFEGVSELEIVREGDRIILRPIRPTWGSFTQLEKADTDFMAEREDVVSDEGRFDL

Download         Length: 231 bp

>AT152348 NZ_CP066125:c4991263-4991009 [Aeromonas veronii]
ATGAAAGTAACCAGCGCCAAGCAGCTGAGCGCCTGTATCAAGGATGCCAGGCTTTCTCAAAAGCTCTCTCAAGGCAAAGT
GGCCGAGAAAGTGGGGATTAGGCAAGACACAGTCTCCAGCTTCGAGCTCAATCCTGAGTCCACCAAGCTGGAGACTCTGT
TCAAAATCCTCGCAGCACTCGAATTGTCACTGGACATCAAACCCCGCAATGAGTCATCCGACAGTCCGGCATCGGGCTGG
AAGGAGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U2MXY5

Antitoxin

Source ID Structure
AlphaFold DB A0A7Y8XMD5

References