Detailed information of TA system TA152346

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 1525902..1526571
• Replicon: chromosome
• Accession: NZ_CP050171
• Organism: Serratia fonticola strain CPSE11

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: U2LMQ5
• Locus tag: HAP32_RS07085
• Protein ID: WP_021179806.1
• Coordinates: 1525902..1526324 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: U2M6Q5
• Locus tag: HAP32_RS07090
• Protein ID: WP_021179805.1
• Coordinates: 1526305..1526571 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HAP32_RS07065	1521746..1522264	+	519	WP_021179810.1	flavodoxin FldB	-
HAP32_RS07070	1522300..1523688	-	1389	WP_166733281.1	cell envelope integrity protein CreD	-
HAP32_RS07075	1523792..1525210	-	1419	WP_021806194.1	two-component system sensor histidine kinase CreC	-
HAP32_RS07080	1525207..1525902	-	696	WP_166733282.1	two-component system response regulator CreB	-
HAP32_RS07085	1525902..1526324	-	423	WP_021179806.1	protein YgfX	Toxin
HAP32_RS07090	1526305..1526571	-	267	WP_021179805.1	FAD assembly factor SdhE	Antitoxin
HAP32_RS07095	1526872..1527864	+	993	WP_166735094.1	tRNA-modifying protein YgfZ	-
HAP32_RS07100	1527904..1528401	-	498	WP_166733283.1	DUF2165 domain-containing protein	-
HAP32_RS07105	1528633..1529307	-	675	WP_037375710.1	hemolysin III family protein	-
HAP32_RS07110	1529544..1530152	+	609	WP_094981477.1	HD domain-containing protein	-
HAP32_RS07115	1530187..1530933	-	747	WP_166733284.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-130)

Antitoxin

• Flavinator of succinate dehydrogenase (7-78)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16466.40 Da
• Isoelectric Point: 10.6373

>T152346 WP_021179806.1 NZ_CP050171:c1526324-1525902 [Serratia fonticola]
VALWRCDVRVSWRTQLVSLLTHGLLILLILIAPWPEGYGPIWLVLLTLVVFECIRSQKRIASRQGELRLLAERRIEWHGR
EWLMVNKPWMPGFGILLSLQQIDGKKRHRLWLASDSMSKADWRQLRQRLSFEPSATDEDV

Nucleotide

• Length: 423 bp

>T152346 NZ_CP066125:2659382-2659738 [Aeromonas veronii]
ATGACAAACAAAGAAAAACCGCTCGAATGGATCGCGAGCAGCCACAAGGATTTGATGGCGTTGCCGTCCGACGTGCGTCG
CCGTTTCGGTTACGCGCTCTCGTTGGCGCAGATAGGCGATCAGGATGACGCAGCAAAGGAGCTCAAGGGGTTCGGTGGTG
CCGGCGTGCTGAAGGTCGTCGAAGACGATGCCGGCGGCACCTATCGAGCGGTATACACGGTCAAGTTTGCGGAAGCGGTG
TTCGTCCTGCACTGCTTCCAGAAGAAGAGCAAGAGCGGAATCGCCACGCCAAAGGCCGACATGGACATCATCCGCGCTCG
GCTGAAGGTGGCCGAGGTATTGGCACAGGAGCTATGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10363.93 Da
• Isoelectric Point: 5.5847

>AT152346 WP_021179805.1 NZ_CP050171:c1526571-1526305 [Serratia fonticola]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDADKAVFIRLLECDDPDLFNWLMNHGAPQDQDLQRMVSLIQMRN
KARGPVAM

Nucleotide

• Length: 267 bp

>AT152346 NZ_CP066125:2659740-2660075 [Aeromonas veronii]
ATGCAAAAACGAATCATTGAAGGCGTCGAGGTTCAGCGCAGCTCGGGCAACGTCTTTGCCGACCTTGGACTGCCTGACGC
TGAAAAGCTCAAGATCAAGACCGGCCTGGTGGTCGAGATCAGGAGGGCCATGCGCGCCCTTGGGCTGACTCAACAAGCGG
CGGCCAAACGCATGGGCATCCCGCAACCGAAGGTGTCGGGCATGATGCGCGGCGACTTCACCAATCTATCCGAACGCAAG
CTGATGGATTGTCTGAATCGCCTCGGCTACGACATCGAAATCAAGGTACGGCCAGCAGCCGAGCCGATCGGGCATCTAAC
GCTCGCAACCGCTTAA

Structures

Toxin

• AlphaFold DB: U2LMQ5

Antitoxin

• AlphaFold DB: U2M6Q5