152334

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 811798..812426 Replicon chromosome
Accession NZ_CP050154
Organism Brevibacterium sp. o2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GUY37_RS03575 Protein ID WP_166822299.1
Coordinates 811798..812172 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GUY37_RS03580 Protein ID WP_166822302.1
Coordinates 812169..812426 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GUY37_RS03550 807038..808639 + 1602 WP_208094748.1 AMP-binding protein -
GUY37_RS03555 808643..809158 - 516 WP_166822287.1 PaaI family thioesterase -
GUY37_RS03560 809161..809601 - 441 WP_166822290.1 PaaI family thioesterase -
GUY37_RS03565 809678..810145 + 468 WP_166822293.1 helix-turn-helix transcriptional regulator -
GUY37_RS03570 810227..811456 - 1230 WP_166822296.1 calcium:proton antiporter -
GUY37_RS03575 811798..812172 - 375 WP_166822299.1 type II toxin-antitoxin system VapC family toxin Toxin
GUY37_RS03580 812169..812426 - 258 WP_166822302.1 ribbon-helix-helix domain-containing protein Antitoxin
GUY37_RS03585 812559..813092 - 534 WP_166822305.1 DUF1453 family protein -
GUY37_RS03590 813172..813798 + 627 WP_166822307.1 TetR family transcriptional regulator C-terminal domain-containing protein -
GUY37_RS03595 813868..814434 - 567 WP_166822310.1 NAD(P)H-dependent oxidoreductase -
GUY37_RS03600 814431..815573 - 1143 WP_166829249.1 LLM class flavin-dependent oxidoreductase -
GUY37_RS03605 815720..816169 - 450 WP_208094749.1 MarR family transcriptional regulator -
GUY37_RS03610 816269..816730 - 462 WP_166829255.1 DoxX family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-105)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-37)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13278.28 Da        Isoelectric Point: 6.2230

>T152334 WP_166822299.1 NZ_CP050154:c812172-811798 [Brevibacterium sp. o2]
MTVVDTSVLIDVLRGREAAKAALFAARADGLLHASEMSRLEVLAGMRRGEDGPTRRLLSVLTWHPVDESISELAGELSRA
WLPGNRGIDSADLAIAATALSLNTTPLTLNVKHFPMFPGLSAPY

Download         Length: 375 bp

>T152334 NZ_CP066123:c740112-739810 [Pseudomonas sp. MPFS]
ATGTTCGTCTTCGAGCAAAACCAGGAGTTCAGCCACTGGCTCACTCGCCTCAAGGACCCTCAGGGGAAGACCCGTGTACT
GGCCCGGATCAGGGCAGCGCAACTAGGGCGGTTCGGCGACTGTGTATCAATAGGAGGTGGAGTCCATGAGATGCGTATCC
ACCGTGGGCCTGGCTACCGGGTGTACTTTTCACGGCGAGGCGAACGGATCTACCTGTTGTTGATCGGTGGCGACAAGAGC
ACCCAGAGTCGCGACATCCAACGAGCCCGGCAACTGGCTCACGACCTCAAGAACGAGGACTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9565.44 Da        Isoelectric Point: 4.4692

>AT152334 WP_166822302.1 NZ_CP050154:c812426-812169 [Brevibacterium sp. o2]
MQRTQISLTIEARRLLDNEASRTGRSISALIRDAVENTYGTGRSTDDAYSAIEEAFGAWIDRQEDGEAYVERLRSGDRLN
QVLSQ

Download         Length: 258 bp

>AT152334 NZ_CP066123:c739806-739516 [Pseudomonas sp. MPFS]
ATGCGCACCCCAGTGACCCGCTTCGATGCGGCCGACTACCTCAAGACCCCGCAAGACATGGTGGCCTACCTCGATGCCTG
CTTCGAGGAAGATGCCGGCGATGGCGTGCTGATCCGCGCCGCCCTCAACGACATCGCCCGCGCCCGGGGCATGACCCAGA
TAGCCCGGGACACCGGCCTGGGCCGCGAAAGCCTGTACAAGGCGCTGGGCAGCCAGGGCAATCCCGAGTTCGCGACTATC
ATCAAGGTGATGAAGGCGCTGGGACTCAAGCTCCAGGTCAGCCCGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References