Detailed information of TA system TA152333

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 35851..36404
• Replicon: chromosome
• Accession: NZ_CP050154
• Organism: Brevibacterium sp. o2

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: GUY37_RS00155
• Protein ID: WP_166820742.1
• Coordinates: 36045..36404 (+)
• Length: 120 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: GUY37_RS00150
• Protein ID: WP_166820739.1
• Coordinates: 35851..36048 (+)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GUY37_RS00130	31442..31660	-	219	WP_166820731.1	DUF2945 domain-containing protein	-
GUY37_RS00135	31805..33130	-	1326	WP_166829043.1	acetylornithine deacetylase	-
GUY37_RS00140	33228..34022	-	795	WP_166820734.1	class I SAM-dependent methyltransferase	-
GUY37_RS00145	34407..35723	+	1317	WP_166820737.1	DUF445 domain-containing protein	-
GUY37_RS00150	35851..36048	+	198	WP_166820739.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
GUY37_RS00155	36045..36404	+	360	WP_166820742.1	type II toxin-antitoxin system VapC family toxin	Toxin
GUY37_RS00160	36412..36801	-	390	Protein_31	VOC family protein	-
GUY37_RS00165	36973..37731	+	759	WP_166820744.1	ABC transporter ATP-binding protein	-
GUY37_RS00170	37731..39149	+	1419	WP_208094728.1	flagellar hook-associated protein	-
GUY37_RS00175	39161..40543	+	1383	WP_166820747.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-113)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-42)

Sequences

Toxin

Protein

• Length: 120 a.a.
• Molecular weight: 13332.19 Da
• Isoelectric Point: 4.9388

>T152333 WP_166820742.1 NZ_CP050154:36045-36404 [Brevibacterium sp. o2]
MILVDTSVWIDHLHSRDESLVRKLEDGEVGSHSAVIEELALGSIRSRTEVLSSLEDLFHFPDLTHEELMMLISSHSLWGR
GLSAVDTHLLGSVILVDGALLWTCDKRLRRAAEELGRAY

Nucleotide

• Length: 360 bp

>T152333 NZ_CP066123:c739806-739516 [Pseudomonas sp. MPFS]
ATGCGCACCCCAGTGACCCGCTTCGATGCGGCCGACTACCTCAAGACCCCGCAAGACATGGTGGCCTACCTCGATGCCTG
CTTCGAGGAAGATGCCGGCGATGGCGTGCTGATCCGCGCCGCCCTCAACGACATCGCCCGCGCCCGGGGCATGACCCAGA
TAGCCCGGGACACCGGCCTGGGCCGCGAAAGCCTGTACAAGGCGCTGGGCAGCCAGGGCAATCCCGAGTTCGCGACTATC
ATCAAGGTGATGAAGGCGCTGGGACTCAAGCTCCAGGTCAGCCCGGCCTGA

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 6933.90 Da
• Isoelectric Point: 8.9774

>AT152333 WP_166820739.1 NZ_CP050154:35851-36048 [Brevibacterium sp. o2]
MRTTVTVDDELVAKAIELSGITERSALVREALKTLVRLESARRLAALGGTDPGSSAAPRRRDDVA

Nucleotide

• Length: 198 bp

>AT152333 NZ_CP066123:c740112-739810 [Pseudomonas sp. MPFS]
ATGTTCGTCTTCGAGCAAAACCAGGAGTTCAGCCACTGGCTCACTCGCCTCAAGGACCCTCAGGGGAAGACCCGTGTACT
GGCCCGGATCAGGGCAGCGCAACTAGGGCGGTTCGGCGACTGTGTATCAATAGGAGGTGGAGTCCATGAGATGCGTATCC
ACCGTGGGCCTGGCTACCGGGTGTACTTTTCACGGCGAGGCGAACGGATCTACCTGTTGTTGATCGGTGGCGACAAGAGC
ACCCAGAGTCGCGACATCCAACGAGCCCGGCAACTGGCTCACGACCTCAAGAACGAGGACTGA