Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yeeU/CbtA-CbeA
Location 4050570..4051370 Replicon chromosome
Accession NZ_CP050150
Organism Hafnia alvei strain A23BA

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag HBA19_RS18570 Protein ID WP_166493650.1
Coordinates 4050570..4050953 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag HBA19_RS18575 Protein ID WP_166493651.1
Coordinates 4051011..4051370 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HBA19_RS18550 4047684..4048337 + 654 WP_166493849.1 molecular chaperone TorD -
HBA19_RS18555 4048720..4048968 - 249 WP_166493647.1 ribbon-helix-helix domain-containing protein -
HBA19_RS18560 4049064..4049912 - 849 WP_166493648.1 DUF4942 domain-containing protein -
HBA19_RS18565 4050082..4050573 - 492 WP_166493649.1 hypothetical protein -
HBA19_RS18570 4050570..4050953 - 384 WP_166493650.1 TA system toxin CbtA family protein Toxin
HBA19_RS18575 4051011..4051370 - 360 WP_166493651.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HBA19_RS18580 4051402..4051623 - 222 WP_166493652.1 DUF987 domain-containing protein -
HBA19_RS18585 4051633..4052106 - 474 WP_166493653.1 hypothetical protein -
HBA19_RS18590 4052116..4052586 - 471 WP_166493654.1 antirestriction protein -
HBA19_RS18595 4052659..4052889 - 231 WP_166493655.1 DUF905 domain-containing protein -
HBA19_RS18600 4052921..4053742 - 822 WP_166493656.1 DUF945 domain-containing protein -
HBA19_RS18605 4053970..4054704 - 735 WP_206023439.1 DUF2971 domain-containing protein -
HBA19_RS18610 4055003..4056154 - 1152 WP_166493657.1 5-methylcytosine-specific restriction endonuclease system specificity protein McrC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-116)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14273.29 Da        Isoelectric Point: 7.3581

>T152326 WP_166493650.1 NZ_CP050150:c4050953-4050570 [Hafnia alvei]
MQTLSLAPQRAVSSCPSPVEIWQQLLMHLLEKHYGLTLSDTPFSNETTIREHIDAGISLSDAVNFLVEKYELVRTDRAGF
TIMEQSPFITPIDILRARQATGLTKRSSYKAVSDITRGKATRLEQSH

Download         Length: 384 bp

>T152326 NZ_CP066122:c70997-70716 [Acinetobacter bereziniae]
ATGGCTATTAAACTTCGCAAATGGGACAGTGCTGAGCATCTTAAAACAGAGGATGATATGCAGGCTTACTTACAAGCATG
TATTGAAGAATCTAATGGCGATGCCGCATTCATTGCAAAGGCTTTAGGTAACATTGCAAAAGCTAAAGGAATGGCTCAAT
TATCACGAGATACAGGCTTAGGCCGAGAAAGTCTTTATAAAGCACTTTCTGGTGATGTTAACCCTAGTTTTGATACTGTG
ATTAAAGTTGTAAAAGCACTGAATTTACGCTTAGCAATTTAA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13395.11 Da        Isoelectric Point: 6.6313

>AT152326 WP_166493651.1 NZ_CP050150:c4051370-4051011 [Hafnia alvei]
MKPVTSAGISQEDNPCLQWGLNRKVTPGFGARLVQEGNRLHFLADRAGFNGAFNEDETLRLDQAFPLMLKELELRLRSGE
LNPRHQHCVTLNHNDLTCEADSLGSHGYIYLTIYPTSQK

Download         Length: 360 bp

>AT152326 NZ_CP066122:c71300-70998 [Acinetobacter bereziniae]
ATGTACTCAATATATACCACTGAAGTCTTTGATGACTGGTTCACCAAGTTAAAAGACCAGCAGGCAAAAAGACGCATACA
AGTCCGAATTGATCGGGTTGAAGATGGAAACTTTGGAGATACTGAGCCGGTCGGTGAAGGTGTTTCTGAATTACGTTTCT
TCTTTGGGCCAGGCTATAGGATTTATTACTGCAAGCAAGGGCAAAGGGTTGTTATTCTTTTAGCAGGCGGAGATAAGTCT
ACGCAAAGTAAAGATATAAAACTTGCCCTGCAATTGGCACAAGATTTAGAGGAGGAGCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References