Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 747254..747914 Replicon chromosome
Accession NZ_CP050150
Organism Hafnia alvei strain A23BA

Toxin (Protein)


Gene name cptA Uniprot ID A0A097QZ25
Locus tag HBA19_RS03470 Protein ID WP_025801622.1
Coordinates 747501..747914 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A097QZ09
Locus tag HBA19_RS03465 Protein ID WP_025801623.1
Coordinates 747254..747520 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HBA19_RS03445 742517..743167 - 651 WP_025801627.1 hemolysin III family protein -
HBA19_RS03450 743828..744712 + 885 WP_043490960.1 nucleoside-specific channel-forming protein Tsx -
HBA19_RS03455 744914..745732 + 819 WP_166492778.1 shikimate 5-dehydrogenase -
HBA19_RS03460 745886..746875 - 990 WP_166492779.1 tRNA-modifying protein YgfZ -
HBA19_RS03465 747254..747520 + 267 WP_025801623.1 FAD assembly factor SdhE Antitoxin
HBA19_RS03470 747501..747914 + 414 WP_025801622.1 protein YgfX Toxin
HBA19_RS03475 748001..748519 - 519 WP_025801621.1 flavodoxin FldB -
HBA19_RS03480 748724..749623 + 900 WP_025801620.1 site-specific tyrosine recombinase XerD -
HBA19_RS03485 749651..750367 + 717 WP_025801619.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HBA19_RS03490 750373..752106 + 1734 WP_043490968.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-133)

Antitoxin

Flavinator of succinate dehydrogenase

(8-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16226.00 Da        Isoelectric Point: 8.5166

>T152314 WP_025801622.1 NZ_CP050150:747501-747914 [Hafnia alvei]
VDQWRCDVRVSWRTQLLLLVTHGILILLILLAPWPENYSFYWLVLLTLVVFECIRSQKQIAKIQGEFSFLADNHIQWQQN
EWELCKTPWISDFGALLPLRSVKPQGKKKRLWIAADSLTPEAWCHLRRTLMQTHQSD

Download         Length: 414 bp

>T152314 NZ_CP066108:c4511606-4511295 [Enterobacter hormaechei]
ATGCTATTCATTGAAACGGATATTTTCACAGAAGACGTCAAAACGTTACTGGATGACGACGAATATCATAGGTTCCAGAT
ATTCCTGGCTACGCAACCGGAGTACGGCGATCTTATCCAGAATACGGGAGGCCTGCGAAAGATTCGCTGGCTTGCTGGCG
GTAAGGGGAAGCGTGGTGGAGTCAGAGTCATCTATTTTCATCGTACGCGTGAGTTTGAAATCAGGTTGCTGCTCATTTAT
CGCAAAGGGATCAAAGATGACCTGTCCGCGAGGGAGAAAGCCATTCTGAAAAAGATGATAGAGAGGTGGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10345.85 Da        Isoelectric Point: 6.0684

>AT152314 WP_025801623.1 NZ_CP050150:747254-747520 [Hafnia alvei]
MDIGNKSRIHWACRRGMRELDISIMPFFEHEYDSLSDADKQTFVRLLECDDPDLFNWLMNHGSPKDPELAHMVKLIQTRN
KDRGPMAL

Download         Length: 267 bp

>AT152314 NZ_CP066108:c4511294-4511004 [Enterobacter hormaechei]
ATGGAGAAGGCGCTGTTTGAGCGATTAACCCAAAGCATTGCGCAAATGAACGAAATTGCCGAGGGCCAACGCGAGCCGTC
GCGTACGTTTCAAATCGATGCGATGAAAATTAAAGAAATCCGTCAGGCATCCGGTCTATCACAGAGTAAATTCGCGAATC
TCATCTCTGTCAGTGTTGATACGTTGCGTAACTGGGAGCAGGGCAGACGCTCACCTACAGGCCCAGCCAAAGCGCTATTG
CGCGCCATTGCTAACGACCCTCAACATGTCATCACTGCGCTATCGCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A097QZ25

Antitoxin

Source ID Structure
AlphaFold DB A0A097QZ09

References