Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 4948137..4948745 Replicon chromosome
Accession NZ_CP050149
Organism Pseudomonas aeruginosa strain CHA

Toxin (Protein)


Gene name PfiT Uniprot ID A0A1B1XUZ2
Locus tag HBA22_RS23185 Protein ID WP_003123043.1
Coordinates 4948137..4948484 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag HBA22_RS23190 Protein ID WP_003114155.1
Coordinates 4948494..4948745 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HBA22_RS23155 (HBA22_23160) 4943557..4943769 + 213 Protein_4592 cysteine-rich CWC family protein -
HBA22_RS23160 (HBA22_23165) 4943769..4944461 + 693 WP_003098362.1 16S rRNA pseudouridine(516) synthase -
HBA22_RS23165 (HBA22_23170) 4944597..4945640 + 1044 WP_003098363.1 L,D-transpeptidase -
HBA22_RS23170 (HBA22_23175) 4945720..4946457 + 738 WP_003085453.1 murein L,D-transpeptidase catalytic domain family protein -
HBA22_RS23175 (HBA22_23180) 4946908..4947810 + 903 WP_003123042.1 (R)-3-hydroxydecanoyl-ACP:CoA transacylase -
HBA22_RS23185 (HBA22_23190) 4948137..4948484 - 348 WP_003123043.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HBA22_RS23190 (HBA22_23195) 4948494..4948745 - 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HBA22_RS23195 (HBA22_23200) 4948959..4949942 - 984 WP_003123044.1 tyrosine-type recombinase/integrase -
HBA22_RS23200 (HBA22_23205) 4949942..4951234 - 1293 WP_003123045.1 hypothetical protein -
HBA22_RS23205 (HBA22_23215) 4951884..4952273 - 390 WP_031687489.1 hypothetical protein -
HBA22_RS23210 (HBA22_23220) 4952266..4952481 - 216 WP_003123046.1 hypothetical protein -
HBA22_RS23215 (HBA22_23225) 4952504..4952719 - 216 WP_003123047.1 hypothetical protein -
HBA22_RS23220 4952837..4953106 + 270 WP_078451377.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12990.74 Da        Isoelectric Point: 4.4212

>T152309 WP_003123043.1 NZ_CP050149:c4948484-4948137 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAAFQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEAAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

>T152309 NZ_CP066108:c1225644-1225399 [Enterobacter hormaechei]
CTGGACGATCTTTACCGGGTACTAAAAAAGGAACACTACCCCTCACCAGACGAGATGCGAAAGCGCTTTCCCAGCCTGGA
CCGGATGAAATACCGGGAAAAATGGTGGGTCATTGAAGTGGGTGGCGGGCATCTAAGAGTAATGTTTTTTGCTGATTTTG
AGCGGGGAAAGATCTTCATCAAACACATCAGCACGCACGCAGAGTATGACAAGCTCACGGACTACTACCGGAGAACGAAA
GAATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT152309 WP_003114155.1 NZ_CP050149:c4948745-4948494 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp

>AT152309 NZ_CP066108:c1225402-1224983 [Enterobacter hormaechei]
ATGAATTATGCAGCAGCCATCAAAGCGGCAAACGCTCTGACAAACGAGCTCCCTTTCCTGGGTTCAACCCCGTCGCGGCA
AGACTACGAGGATGCGCTGGCGCTGGTGGAGTATCTTATCGAGCACGACCCGGATAACCCGCTGGTAGATATGCTCACTG
CCAAAATCGATAAGTACGAAAACGAGTCCCCGGAATTTGCAGAATTTAACGCGCGTATTGCCAGTATTCCGTCAGGCGTT
GCGTTACTGCGAACGCTGATGGATCAGTACCAACTCACTCAGAGTGATTTCGAGAACGAGATTGGTAAGAAGTCTCTGGT
GAGTCGGATCCTGAACGGACAGCGCACGTTAACGCTGGATCATATGCGTGCGCTGGCGAAGCGTTTTGGTTTGCCGGTGA
GTGCGTTTGTTGGGAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1XUZ2

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References