Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | PfiT-PfiA/ParE(toxin) |
Location | 4948137..4948745 | Replicon | chromosome |
Accession | NZ_CP050149 | ||
Organism | Pseudomonas aeruginosa strain CHA |
Toxin (Protein)
Gene name | PfiT | Uniprot ID | A0A1B1XUZ2 |
Locus tag | HBA22_RS23185 | Protein ID | WP_003123043.1 |
Coordinates | 4948137..4948484 (-) | Length | 116 a.a. |
Antitoxin (Protein)
Gene name | PfiA | Uniprot ID | A0A0B0C355 |
Locus tag | HBA22_RS23190 | Protein ID | WP_003114155.1 |
Coordinates | 4948494..4948745 (-) | Length | 84 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HBA22_RS23155 (HBA22_23160) | 4943557..4943769 | + | 213 | Protein_4592 | cysteine-rich CWC family protein | - |
HBA22_RS23160 (HBA22_23165) | 4943769..4944461 | + | 693 | WP_003098362.1 | 16S rRNA pseudouridine(516) synthase | - |
HBA22_RS23165 (HBA22_23170) | 4944597..4945640 | + | 1044 | WP_003098363.1 | L,D-transpeptidase | - |
HBA22_RS23170 (HBA22_23175) | 4945720..4946457 | + | 738 | WP_003085453.1 | murein L,D-transpeptidase catalytic domain family protein | - |
HBA22_RS23175 (HBA22_23180) | 4946908..4947810 | + | 903 | WP_003123042.1 | (R)-3-hydroxydecanoyl-ACP:CoA transacylase | - |
HBA22_RS23185 (HBA22_23190) | 4948137..4948484 | - | 348 | WP_003123043.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
HBA22_RS23190 (HBA22_23195) | 4948494..4948745 | - | 252 | WP_003114155.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
HBA22_RS23195 (HBA22_23200) | 4948959..4949942 | - | 984 | WP_003123044.1 | tyrosine-type recombinase/integrase | - |
HBA22_RS23200 (HBA22_23205) | 4949942..4951234 | - | 1293 | WP_003123045.1 | hypothetical protein | - |
HBA22_RS23205 (HBA22_23215) | 4951884..4952273 | - | 390 | WP_031687489.1 | hypothetical protein | - |
HBA22_RS23210 (HBA22_23220) | 4952266..4952481 | - | 216 | WP_003123046.1 | hypothetical protein | - |
HBA22_RS23215 (HBA22_23225) | 4952504..4952719 | - | 216 | WP_003123047.1 | hypothetical protein | - |
HBA22_RS23220 | 4952837..4953106 | + | 270 | WP_078451377.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 116 a.a. Molecular weight: 12990.74 Da Isoelectric Point: 4.4212
>T152309 WP_003123043.1 NZ_CP050149:c4948484-4948137 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAAFQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEAAVILVLRQKQSVEQQLIRYCLVGPIE
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAAFQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEAAVILVLRQKQSVEQQLIRYCLVGPIE
Download Length: 348 bp
>T152309 NZ_CP066108:c1225644-1225399 [Enterobacter hormaechei]
CTGGACGATCTTTACCGGGTACTAAAAAAGGAACACTACCCCTCACCAGACGAGATGCGAAAGCGCTTTCCCAGCCTGGA
CCGGATGAAATACCGGGAAAAATGGTGGGTCATTGAAGTGGGTGGCGGGCATCTAAGAGTAATGTTTTTTGCTGATTTTG
AGCGGGGAAAGATCTTCATCAAACACATCAGCACGCACGCAGAGTATGACAAGCTCACGGACTACTACCGGAGAACGAAA
GAATGA
CTGGACGATCTTTACCGGGTACTAAAAAAGGAACACTACCCCTCACCAGACGAGATGCGAAAGCGCTTTCCCAGCCTGGA
CCGGATGAAATACCGGGAAAAATGGTGGGTCATTGAAGTGGGTGGCGGGCATCTAAGAGTAATGTTTTTTGCTGATTTTG
AGCGGGGAAAGATCTTCATCAAACACATCAGCACGCACGCAGAGTATGACAAGCTCACGGACTACTACCGGAGAACGAAA
GAATGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9442.79 Da Isoelectric Point: 9.4808
>AT152309 WP_003114155.1 NZ_CP050149:c4948745-4948494 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE
Download Length: 252 bp
>AT152309 NZ_CP066108:c1225402-1224983 [Enterobacter hormaechei]
ATGAATTATGCAGCAGCCATCAAAGCGGCAAACGCTCTGACAAACGAGCTCCCTTTCCTGGGTTCAACCCCGTCGCGGCA
AGACTACGAGGATGCGCTGGCGCTGGTGGAGTATCTTATCGAGCACGACCCGGATAACCCGCTGGTAGATATGCTCACTG
CCAAAATCGATAAGTACGAAAACGAGTCCCCGGAATTTGCAGAATTTAACGCGCGTATTGCCAGTATTCCGTCAGGCGTT
GCGTTACTGCGAACGCTGATGGATCAGTACCAACTCACTCAGAGTGATTTCGAGAACGAGATTGGTAAGAAGTCTCTGGT
GAGTCGGATCCTGAACGGACAGCGCACGTTAACGCTGGATCATATGCGTGCGCTGGCGAAGCGTTTTGGTTTGCCGGTGA
GTGCGTTTGTTGGGAATTAA
ATGAATTATGCAGCAGCCATCAAAGCGGCAAACGCTCTGACAAACGAGCTCCCTTTCCTGGGTTCAACCCCGTCGCGGCA
AGACTACGAGGATGCGCTGGCGCTGGTGGAGTATCTTATCGAGCACGACCCGGATAACCCGCTGGTAGATATGCTCACTG
CCAAAATCGATAAGTACGAAAACGAGTCCCCGGAATTTGCAGAATTTAACGCGCGTATTGCCAGTATTCCGTCAGGCGTT
GCGTTACTGCGAACGCTGATGGATCAGTACCAACTCACTCAGAGTGATTTCGAGAACGAGATTGGTAAGAAGTCTCTGGT
GAGTCGGATCCTGAACGGACAGCGCACGTTAACGCTGGATCATATGCGTGCGCTGGCGAAGCGTTTTGGTTTGCCGGTGA
GTGCGTTTGTTGGGAATTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1B1XUZ2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0B0C355 |