Detailed information of TA system TA152307

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 3587649..3588870
• Replicon: chromosome
• Accession: NZ_CP050149
• Organism: Pseudomonas aeruginosa strain CHA

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: HBA22_RS16525
• Protein ID: WP_003114949.1
• Coordinates: 3588292..3588870 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: HBA22_RS16520
• Protein ID: WP_003088112.1
• Coordinates: 3587649..3588203 (+)
• Length: 185 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HBA22_RS16495 (HBA22_16480)	3583217..3583768	+	552	WP_003102727.1	XRE family transcriptional regulator	-
HBA22_RS16500 (HBA22_16485)	3583765..3584163	-	399	WP_003088123.1	NADH-quinone oxidoreductase subunit A	-
HBA22_RS16505 (HBA22_16490)	3584176..3584499	-	324	WP_003102734.1	multidrug efflux SMR transporter	-
HBA22_RS16510 (HBA22_16495)	3584830..3585291	+	462	WP_003102736.1	(2Fe-2S)-binding protein	-
HBA22_RS16515 (HBA22_16500)	3585296..3587491	+	2196	WP_003122807.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
HBA22_RS16520 (HBA22_16505)	3587649..3588203	+	555	WP_003088112.1	helix-turn-helix transcriptional regulator	Antitoxin
HBA22_RS16525 (HBA22_16510)	3588292..3588870	+	579	WP_003114949.1	HD domain-containing protein	Toxin
HBA22_RS16530 (HBA22_16515)	3588978..3590165	-	1188	WP_003102741.1	HlyD family efflux transporter periplasmic adaptor subunit	-
HBA22_RS16535 (HBA22_16520)	3590155..3592326	-	2172	WP_003088105.1	type I secretion system permease/ATPase	-
HBA22_RS16540 (HBA22_16525)	3592316..3593593	-	1278	WP_003122808.1	TolC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HD domain (16-170)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-62)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21897.75 Da
• Isoelectric Point: 5.3655

>T152307 WP_003114949.1 NZ_CP050149:3588292-3588870 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA

Nucleotide

• Length: 579 bp

>T152307 NZ_CP066108:c936895-936554 [Enterobacter hormaechei]
ATGAAACCTCTACCTGCAACAACTTCGCGGGCGGCGAAGCCTTGTCTGTCGCCCGTTGCAGTCTGGCAAATACTGCTTAC
ACACCTGCTGGAGCAGCACTATGGTCTGACGCTAAACGATACGCCGTTCAGTGATGAAACCGTTATTAAGGAACATATTG
ATGCCGGGATCACCCTGGCCGATGCCGTTAATTTTCTGGTGGAGAAATACGAGCTGGTGCGTATAGATCGCAGGGGATTT
AGCAGGCAGGAACAATCGCCTTATCTCCGGGCTGTAGACATTCTGCGAGCGCGGCAGGTAACTGGCCTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA

Antitoxin

Protein

• Length: 185 a.a.
• Molecular weight: 20454.63 Da
• Isoelectric Point: 8.1590

>AT152307 WP_003088112.1 NZ_CP050149:3587649-3588203 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Nucleotide

• Length: 555 bp

>AT152307 NZ_CP066108:c937233-936916 [Enterobacter hormaechei]
ATGAGCAATATCACATGGGGCCTGCAGCGGAATATCACGCCGCGCCTGGGAGCCCGTCTGGTGCAGGATAGGAACCGGAT
GCATTATCTGGCTGACCGGGCAAGTATCACCGGTAAGTTTAGTGATGCCGAATGCCTGAAGTTGGATGTCGCATTCCCGC
ATTTTATCAGTCAGATGGAATCAATGCTGACCACCGGTGAACTGAATCCCCGCCATCCACACTGCATCGCCCTGTATCAC
AACGGTTTTACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCTGTTTATCCCAGCCAACGCTAA