Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 142396..142901 Replicon chromosome
Accession NZ_CP050149
Organism Pseudomonas aeruginosa strain CHA

Toxin (Protein)


Gene name parE Uniprot ID A0A069QL22
Locus tag HBA22_RS00645 Protein ID WP_003121619.1
Coordinates 142396..142677 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag HBA22_RS00650 Protein ID WP_003112628.1
Coordinates 142674..142901 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HBA22_RS00620 (HBA22_00615) 137647..138996 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
HBA22_RS00625 (HBA22_00620) 139045..139731 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
HBA22_RS00630 (HBA22_00625) 139832..140566 + 735 WP_003117208.1 GntR family transcriptional regulator -
HBA22_RS00635 (HBA22_00630) 140746..141156 + 411 WP_003101225.1 aegerolysin family protein -
HBA22_RS00640 (HBA22_00635) 141188..142096 - 909 WP_003083769.1 LysR family transcriptional regulator -
HBA22_RS00645 (HBA22_00640) 142396..142677 - 282 WP_003121619.1 type II toxin-antitoxin system toxin ParE Toxin
HBA22_RS00650 (HBA22_00645) 142674..142901 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
HBA22_RS00655 (HBA22_00650) 143077..143697 - 621 WP_003101226.1 hypothetical protein -
HBA22_RS00660 (HBA22_00655) 143798..144298 + 501 WP_003112629.1 LEA type 2 family protein -
HBA22_RS00665 (HBA22_00660) 144371..144712 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
HBA22_RS00670 (HBA22_00665) 144794..146221 - 1428 WP_003121620.1 GABA permease -
HBA22_RS00675 (HBA22_00670) 146390..147883 - 1494 WP_031653061.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10492.22 Da        Isoelectric Point: 10.0435

>T152305 WP_003121619.1 NZ_CP050149:c142677-142396 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T152305 NZ_CP066105:c8249-7986 [Enterobacter hormaechei]
ATGACACTAAGAAAGCAACACCAACGAACCCTAGAGGCTATTTATCGACGCCCGGTTAGTGGCACGATTGAATACAAGGA
TTTTAAAGCCTTAATGCTGGCGCTGGGCGCAGAGCTTGACGAAAGCGCAGCAGGATCGCGAGAAGGTTTTACGTTACGGG
GAGAGCCGCGAGTGTTTCACCGCCCGCACCCTAAAAGCACGATGGATAAGGGCGCAGTAAGTGAAGCCCGCCAATGGTTA
GAGAGATTGGGGATCAAACCATGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT152305 WP_003112628.1 NZ_CP050149:c142901-142674 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp

>AT152305 NZ_CP066105:c7989-7648 [Enterobacter hormaechei]
ATGATTAATGTGATGAAAGTCAACGGCCACGCCGCAACCGTGGCTTTTGACCCTGAGATCGAAATGTTTCGAGGTAGCTT
TGTCGGCCTGACTGGCGGCGCAGATTTCTATGCCCGCACGGTTGAAGAGTTACACCGCGAGGGCGCGGAATCTTTGCGCT
TTTATCTGGAGATCTGCGAGAAGCGCGGGATCGAGCCGTATAAAGCCTATAGCGGCAAGGTTAGCACCCGTTTAACGCCG
GAGCGTCACCAGGCGTTAGAGCAGATCGCAGCAGCCCACGGCGAAAGCATTAACCAGCTTTTAAACGAGGGCGCGGATCT
GGTTATCGAACGTTACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069QL22

Antitoxin

Source ID Structure
PDB 6XRW
AlphaFold DB Q9I707

References