Detailed information of TA system TA152302

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 3469595..3470816
• Replicon: chromosome
• Accession: NZ_CP050148
• Organism: Pseudomonas aeruginosa strain AA43

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A0C7CS07
• Locus tag: HBA21_RS15935
• Protein ID: WP_003102740.1
• Coordinates: 3470238..3470816 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: HBA21_RS15930
• Protein ID: WP_003088112.1
• Coordinates: 3469595..3470149 (+)
• Length: 185 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HBA21_RS15905 (HBA21_15955)	3465163..3465714	+	552	WP_003450159.1	XRE family transcriptional regulator	-
HBA21_RS15910 (HBA21_15960)	3465711..3466109	-	399	WP_023089053.1	NADH-quinone oxidoreductase subunit A	-
HBA21_RS15915 (HBA21_15965)	3466122..3466445	-	324	WP_003102734.1	multidrug efflux SMR transporter	-
HBA21_RS15920 (HBA21_15970)	3466776..3467237	+	462	WP_003102736.1	(2Fe-2S)-binding protein	-
HBA21_RS15925 (HBA21_15975)	3467242..3469437	+	2196	WP_058007015.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
HBA21_RS15930 (HBA21_15980)	3469595..3470149	+	555	WP_003088112.1	helix-turn-helix transcriptional regulator	Antitoxin
HBA21_RS15935 (HBA21_15985)	3470238..3470816	+	579	WP_003102740.1	HD domain-containing protein	Toxin
HBA21_RS15940 (HBA21_15990)	3470925..3472112	-	1188	WP_003102741.1	HlyD family efflux transporter periplasmic adaptor subunit	-
HBA21_RS15945 (HBA21_15995)	3472102..3474273	-	2172	WP_003114950.1	type I secretion system permease/ATPase	-
HBA21_RS15950 (HBA21_16000)	3474263..3475540	-	1278	WP_003102743.1	TolC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HD domain (16-170)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-62)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21869.70 Da
• Isoelectric Point: 5.3655

>T152302 WP_003102740.1 NZ_CP050148:3470238-3470816 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Nucleotide

• Length: 579 bp

>T152302 NZ_CP066101:c4512706-4512395 [Enterobacter hormaechei]
ATGCTATTCATTGAAACGGATATTTTCACAGAAGACGTCAAAACGTTACTGGATGACGACGAATATCATAGGTTCCAGAT
ATTCCTGGCTACGCAACCGGAGTACGGCGATCTTATCCAGAATACGGGAGGCCTGCGAAAGATTCGCTGGCTTGCTGGCG
GTAAGGGGAAGCGTGGTGGAGTCAGAGTCATCTATTTTCATCGTACGCGTGAGTTTGAAATCAGGTTGCTGCTCATTTAT
CGCAAAGGGATCAAAGATGACCTGTCCGCGAGGGAGAAAGCCATTCTGAAAAAGATGATAGAGAGGTGGTAA

Antitoxin

Protein

• Length: 185 a.a.
• Molecular weight: 20454.63 Da
• Isoelectric Point: 8.1590

>AT152302 WP_003088112.1 NZ_CP050148:3469595-3470149 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Nucleotide

• Length: 555 bp

>AT152302 NZ_CP066101:c4512394-4512104 [Enterobacter hormaechei]
ATGGAGAAGGCGCTGTTTGAGCGATTAACCCAAAGCATTGCGCAAATGAACGAAATTGCCGAGGGCCAACGCGAGCCGTC
GCGTACGTTTCAAATCGATGCGATGAAAATTAAAGAAATCCGTCAGGCATCCGGTCTATCACAGAGTAAATTCGCGAATC
TCATCTCTGTCAGTGTTGATACGTTGCGTAACTGGGAGCAGGGCAGACGCTCACCTACAGGCCCAGCCAAAGCGCTATTG
CGCGCCATTGCTAACGACCCTCAACATGTCATCACTGCGCTATCGCAGTAA

Structures

Toxin

• AlphaFold DB: A0A0C7CS07