Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1822904..1824412 Replicon chromosome
Accession NZ_CP050148
Organism Pseudomonas aeruginosa strain AA43

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag HBA21_RS08495 Protein ID WP_003119682.1
Coordinates 1822904..1823491 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A1C7C4U7
Locus tag HBA21_RS08500 Protein ID WP_003091607.1
Coordinates 1823558..1824412 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HBA21_RS08490 (HBA21_08505) 1819159..1822638 - 3480 WP_003117605.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
HBA21_RS08495 (HBA21_08510) 1822904..1823491 + 588 WP_003119682.1 GNAT family protein Toxin
HBA21_RS08500 (HBA21_08515) 1823558..1824412 + 855 WP_003091607.1 AraC family transcriptional regulator Antitoxin
HBA21_RS08505 (HBA21_08520) 1824509..1826674 + 2166 WP_003091606.1 TonB-dependent receptor family protein -
HBA21_RS08510 (HBA21_08525) 1826849..1828723 + 1875 WP_003091605.1 MFS transporter -
HBA21_RS08515 (HBA21_08530) 1828784..1828993 - 210 WP_003091604.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T152301 WP_003119682.1 NZ_CP050148:1822904-1823491 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

>T152301 NZ_CP066101:c3634800-3634390 [Enterobacter hormaechei]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGTCTGGTCGCGGC
ATTGGTGTTACTGGTGCCGTGGCCACTTAGCTATACCCCGCTGTGGTTGCTATTACTGTCGTTTGTGGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAGATGACAGGGACGCCGTGGATGCTTAACACGGGGATGATGCTACGGCTGCGACGGGTTGAGGACAATCGTCG
CGAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCCGCAGAGTGGCGTGATCTGCGCCGGTTGATTGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31895.20 Da        Isoelectric Point: 7.5295

>AT152301 WP_003091607.1 NZ_CP050148:1823558-1824412 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETMLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTTYE

Download         Length: 855 bp

>AT152301 NZ_CP066101:c3635047-3634781 [Enterobacter hormaechei]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAGCTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7C4U7

References