Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 5163770..5164378 Replicon chromosome
Accession NZ_CP050147
Organism Pseudomonas aeruginosa strain A5803

Toxin (Protein)


Gene name PfiT Uniprot ID A0A1B1XUZ2
Locus tag HBA20_RS24365 Protein ID WP_003123043.1
Coordinates 5163770..5164117 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag HBA20_RS24370 Protein ID WP_003114155.1
Coordinates 5164127..5164378 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HBA20_RS24345 (HBA20_24375) 5159704..5160201 + 498 Protein_4831 heat resistance protein PsiE-GI -
HBA20_RS24350 (HBA20_24380) 5160179..5161144 + 966 WP_003141083.1 zinc metalloprotease HtpX -
HBA20_RS24355 (HBA20_24385) 5161169..5162320 + 1152 WP_012761372.1 trypsin-like peptidase domain-containing protein -
HBA20_RS24360 (HBA20_24390) 5162553..5163461 + 909 WP_003141085.1 LysR family transcriptional regulator -
HBA20_RS24365 (HBA20_24395) 5163770..5164117 - 348 WP_003123043.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HBA20_RS24370 (HBA20_24400) 5164127..5164378 - 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HBA20_RS24375 (HBA20_24405) 5164592..5165575 - 984 WP_003114154.1 tyrosine-type recombinase/integrase -
HBA20_RS24380 (HBA20_24410) 5165575..5166867 - 1293 WP_003123045.1 hypothetical protein -
HBA20_RS24385 (HBA20_24415) 5167097..5168371 - 1275 WP_058154821.1 zonular occludens toxin family protein -
HBA20_RS24390 (HBA20_24420) 5168375..5168731 - 357 WP_003114150.1 DUF2523 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 5162553..5178412 15859


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12990.74 Da        Isoelectric Point: 4.4212

>T152298 WP_003123043.1 NZ_CP050147:c5164117-5163770 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAAFQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEAAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

>T152298 NZ_CP066101:1685218-1685739 [Enterobacter hormaechei]
GTGGCAAATCTCACGATCGAAATGTTATCAGAGGGAACCGATTACGATTTCGGCAATTTCGATTGTGGTGAACCCTCGCT
CAATGCCTTCCTTACCGATCACCTGGTACGTCAGCACAGCGGACGTATTTTACGCGGCTACCTACTTAAAGAACGCGACC
ACCCACGTATCCTGGGCTATTACACGCTTTCGGGAAGTTGCTTTGAAAAAGCGATGCTTCCTTCAAAGACTCAGCAGCGC
CGCATCCCATACAGCAACGTCCCCAGCGTGACGCTGGGACGTCTGGCTGTCCATAAAGAACTACAGGGAAACGAGTGGGG
AACAACGCTTGTCACACACGCTATGCGCGTTGTTTATCTGGCGTCGCAGGCTGTTGGCGTCCACGGAATTTTTGTGGATG
CGCTTAACGAACGGGCCAAACGATTTTATCTGAAGCTGGGGTTTATCCCGCTGGCAGGTGAAAACAGCAGTTCACTGTTC
TTCCCCACGCAATCTATCGAACGACTGTTTGAGCAGGTGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT152298 WP_003114155.1 NZ_CP050147:c5164378-5164127 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp

>AT152298 NZ_CP066101:1684942-1685211 [Enterobacter hormaechei]
ATGCCAGCACTTAAAAAACAGCGTATCGATCTTCGCTTATCGGACGAAGACAAAACAATGATTGAAGAAGCGGCAGCGAT
GACCAACCAAACGATCACCCAGTTTATGGTGAACAGTGCGTCAGAGCGGGCTGCCGAAGTCATCGAACAGCATCGGCGTC
TCGTATTAAACGAAGCCTCATGGAATGCCGTTATGGATGCCATCGATAATCCGCCAGAGCCAAATGAACGCCTGAAACGC
GCGGCGAAACGTCTTCGAAACATGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1XUZ2

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References