Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 2482371..2483413 | Replicon | chromosome |
| Accession | NZ_CP050147 | ||
| Organism | Pseudomonas aeruginosa strain A5803 | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | - |
| Locus tag | HBA20_RS11875 | Protein ID | WP_003109777.1 |
| Coordinates | 2482838..2483413 (+) | Length | 192 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | I3TV68 |
| Locus tag | HBA20_RS11870 | Protein ID | WP_003050245.1 |
| Coordinates | 2482371..2482841 (+) | Length | 157 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HBA20_RS11835 (HBA20_11860) | 2477763..2479181 | - | 1419 | WP_003109776.1 | TIGR03752 family integrating conjugative element protein | - |
| HBA20_RS11840 (HBA20_11865) | 2479171..2480082 | - | 912 | WP_003105643.1 | TIGR03749 family integrating conjugative element protein | - |
| HBA20_RS11845 (HBA20_11870) | 2480079..2480771 | - | 693 | WP_003105641.1 | TIGR03746 family integrating conjugative element protein | - |
| HBA20_RS11850 (HBA20_11875) | 2480768..2481166 | - | 399 | WP_003105639.1 | TIGR03750 family conjugal transfer protein | - |
| HBA20_RS11855 (HBA20_11880) | 2481178..2481537 | - | 360 | WP_003090173.1 | TIGR03745 family integrating conjugative element membrane protein | - |
| HBA20_RS11860 (HBA20_11885) | 2481554..2481787 | - | 234 | WP_003050225.1 | TIGR03758 family integrating conjugative element protein | - |
| HBA20_RS11865 (HBA20_11890) | 2481784..2482167 | - | 384 | WP_003105635.1 | RAQPRD family integrative conjugative element protein | - |
| HBA20_RS11870 (HBA20_11895) | 2482371..2482841 | + | 471 | WP_003050245.1 | helix-turn-helix domain-containing protein | Antitoxin |
| HBA20_RS11875 (HBA20_11900) | 2482838..2483413 | + | 576 | WP_003109777.1 | PIN domain-containing protein | Toxin |
| HBA20_RS11880 (HBA20_11905) | 2483431..2484345 | + | 915 | WP_003105629.1 | AAA family ATPase | - |
| HBA20_RS11885 (HBA20_11910) | 2484342..2484812 | + | 471 | WP_003105626.1 | type III CBASS phage resistance system CD-NTase-associated protein Cap8 | - |
| HBA20_RS11890 (HBA20_11915) | 2484809..2485309 | + | 501 | WP_003090159.1 | type III CBASS phage resistance system CD-NTase-associated protein Cap7 | - |
| HBA20_RS11895 (HBA20_11920) | 2485309..2486211 | + | 903 | WP_003105624.1 | CBASS oligonucleotide cyclase | - |
| HBA20_RS11900 (HBA20_11925) | 2486250..2486975 | + | 726 | WP_003050273.1 | CBASS effector endonuclease NucC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 2432533..2528817 | 96284 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 192 a.a. Molecular weight: 21644.79 Da Isoelectric Point: 5.6172
>T152294 WP_003109777.1 NZ_CP050147:2482838-2483413 [Pseudomonas aeruginosa]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPDDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIEVDRYLEILLRQGLVQTTKVLATYRTIL
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPDDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIEVDRYLEILLRQGLVQTTKVLATYRTIL
Download Length: 576 bp
>T152294 NZ_CP066101:66874-67266 [Enterobacter hormaechei]
ATGCTGCATATGCTGGACACTAACATCGTAAGCCATCTGGTGAGGCAGCATCCTGAAGTAGTAAACCGATATTCGCAAAT
TACGCCTGAAAAGATGTGTATTTCAAGCGTAACGGAAGCGGAATTGCTTTACGGCGTAGCCAAAAAGCAAAACAACAAGC
TGCACGAAACCATAATGGAATTTCTTAAAACCATCACTATCTGCGCCTGGGATAGCGAAGCCGCAGCCACCTACGGTGAA
CTGCGTGCGGCAATGGAAAAGAAAGGGAAAGTGATGGGGGATCTCGATCAGTTGATTGCAGCACATGCTATCAGCCGGGG
CACGACGATTGTCACGAACGATCATGCGTTCGGGATGGTACAGGATCTTACGGTTGAGGACTGGACTCAATAA
ATGCTGCATATGCTGGACACTAACATCGTAAGCCATCTGGTGAGGCAGCATCCTGAAGTAGTAAACCGATATTCGCAAAT
TACGCCTGAAAAGATGTGTATTTCAAGCGTAACGGAAGCGGAATTGCTTTACGGCGTAGCCAAAAAGCAAAACAACAAGC
TGCACGAAACCATAATGGAATTTCTTAAAACCATCACTATCTGCGCCTGGGATAGCGAAGCCGCAGCCACCTACGGTGAA
CTGCGTGCGGCAATGGAAAAGAAAGGGAAAGTGATGGGGGATCTCGATCAGTTGATTGCAGCACATGCTATCAGCCGGGG
CACGACGATTGTCACGAACGATCATGCGTTCGGGATGGTACAGGATCTTACGGTTGAGGACTGGACTCAATAA
Antitoxin
Download Length: 157 a.a. Molecular weight: 17245.62 Da Isoelectric Point: 6.3803
>AT152294 WP_003050245.1 NZ_CP050147:2482371-2482841 [Pseudomonas aeruginosa]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE
Download Length: 471 bp
>AT152294 NZ_CP066101:66610-66870 [Enterobacter hormaechei]
ATGGAACGCACAGCGAAACTATTTAAAAAAGGACGAAACCAGGCCGTGGTCTTGCCTGCGGAATTTGCATTTGAAACGGA
GAGTGTTTATATCCGCCGGGATGACGAGGGGAATGTGGTTTTGACGGCAAGGTCCGAGAAAGAACGACACAGAGATAACT
TTTTGCGCATGCTAAGACAAACGCATGTGCCTGATACCTTTCTAAGTAAAGAGGAGCGCAATCAGAGCTATACGACAAGA
AATCCTCTGGAAGGGCTGTAG
ATGGAACGCACAGCGAAACTATTTAAAAAAGGACGAAACCAGGCCGTGGTCTTGCCTGCGGAATTTGCATTTGAAACGGA
GAGTGTTTATATCCGCCGGGATGACGAGGGGAATGTGGTTTTGACGGCAAGGTCCGAGAAAGAACGACACAGAGATAACT
TTTTGCGCATGCTAAGACAAACGCATGTGCCTGATACCTTTCTAAGTAAAGAGGAGCGCAATCAGAGCTATACGACAAGA
AATCCTCTGGAAGGGCTGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|