Detailed information of TA system TA152289

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 3466944..3467485
• Replicon: chromosome
• Accession: NZ_CP050139
• Organism: Komagataeibacter rhaeticus strain ENS 9a1a

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: GWK63_RS16060
• Protein ID: WP_202795781.1
• Coordinates: 3467183..3467485 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A181C5T9
• Locus tag: GWK63_RS16055
• Protein ID: WP_039998678.1
• Coordinates: 3466944..3467186 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GWK63_RS16025	3463152..3463385	-	234	WP_099963248.1	hypothetical protein	-
GWK63_RS16030	3463426..3464126	+	701	Protein_3146	hypothetical protein	-
GWK63_RS16035	3464101..3464472	+	372	WP_172459683.1	hypothetical protein	-
GWK63_RS16040	3464840..3464998	+	159	WP_156953886.1	hypothetical protein	-
GWK63_RS16045	3465059..3466209	+	1151	WP_085948976.1	IS3 family transposase	-
GWK63_RS16050	3466234..3466405	-	172	Protein_3150	transposase	-
GWK63_RS16055	3466944..3467186	+	243	WP_039998678.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
GWK63_RS16060	3467183..3467485	+	303	WP_202795781.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3451207..3524512	73305
	-	flank	IS/Tn	-	-	3465059..3465325	266

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-93)

Antitoxin

• Antitoxin ParD (1-76)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11434.00 Da
• Isoelectric Point: 7.3581

>T152289 WP_202795781.1 NZ_CP050139:3467183-3467485 [Komagataeibacter rhaeticus]
VMRFLLRPAAQADLSAIWDYSAQRWGTTQADDYVRAIGRACQDLADGTRHGRTADDIREGYLKMLVGSHLLFFRVNENGF
IDVIRILHGRMDPTRHMTDV

Nucleotide

• Length: 303 bp

>T152289 NZ_CP066094:3862006-3862305 [Enterobacter hormaechei]
ATGATTAATCATTCTCGGGATCAATGGCTTGAGGATTTTTTTCTCTACGGGAGATCGAGCAATGTTATTCCTTTGAATCT
GGAAACAGCGCTTGCAAGAAAGCTCGACATCATCAATGCGGCCATGTCGCACCTGGATTTACGATCGCCACCGGGCAATA
TGTATGAAGCATTGAGTCCTCCGTTGAAGGGATATTCCTCTATCCGGGTAAACAGACAATACAGGCTTGTATTTCGCTGG
TCAGAGGGAAAAGCAGACGATCTCTATCTCTCTCCACACAAGTACACGCAACACAAGTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8829.82 Da
• Isoelectric Point: 4.7962

>AT152289 WP_039998678.1 NZ_CP050139:3466944-3467186 [Komagataeibacter rhaeticus]
MARNTSISLGDHFADFVDQQVKGGRYGSASDVVRAGLRILEERETRLETLRSALIDGEQSGAAEPFDIEDFLAAKAKQFR

Nucleotide

• Length: 243 bp

>AT152289 NZ_CP066094:3862316-3862681 [Enterobacter hormaechei]
ATGACACTTCAACAGGCACTCCGCAAACCCACCACGCCGGGCGAGGTGTTGCAGTATGAGTATCTTGAACCGCTCAATCT
GAAAATCAACGATCTGGCAGAGATGCTAAATGTACACCGCAATACCGTAAGCGCGTTGGTCAATAACAATCGCAAACTTA
CTGCCGATATGGCGATCAAACTGGCAAAAGCCTTTAATACCACTATTGAATTTTGGCTGAACTTACAGCTAAACGTTGAT
ATCTGGGAAGCGCAATCTAACTCCCGCACGCAGGAGGAGTTAAGCCGGATAAAAACCGTTGCGGAAGTCATGGCGAAGCG
AAAATCCGGCAAGCCAGACGTTACCCTGCACGGGAACAGCGCATAA

Structures

Antitoxin

• AlphaFold DB: A0A181C5T9