Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 430131..430731 Replicon chromosome
Accession NZ_CP050139
Organism Komagataeibacter rhaeticus strain ENS 9a1a

Toxin (Protein)


Gene name relE Uniprot ID F7VHK4
Locus tag GWK63_RS02130 Protein ID WP_006559873.1
Coordinates 430387..430731 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID W5YEQ9
Locus tag GWK63_RS02125 Protein ID WP_010511780.1
Coordinates 430131..430394 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GWK63_RS02090 425539..426560 - 1022 Protein_408 IS110 family transposase -
GWK63_RS02095 426900..427088 - 189 WP_112209847.1 hypothetical protein -
GWK63_RS02100 427169..427726 + 558 WP_112209845.1 phosphate-starvation-inducible PsiE family protein -
GWK63_RS02105 428192..428674 - 483 WP_112210156.1 Hsp20 family protein -
GWK63_RS02110 428710..428991 - 282 WP_112209841.1 hypothetical protein -
GWK63_RS17030 429152..429253 + 102 WP_124296136.1 YXWGXW repeat-containing protein -
GWK63_RS02120 429774..430022 + 249 WP_010511782.1 hypothetical protein -
GWK63_RS02125 430131..430394 + 264 WP_010511780.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
GWK63_RS02130 430387..430731 + 345 WP_006559873.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GWK63_RS02135 431006..431428 + 423 WP_166498090.1 hypothetical protein -
GWK63_RS02140 431456..433672 + 2217 WP_166498091.1 EAL domain-containing protein -
GWK63_RS02145 433909..434665 + 757 WP_166498092.1 IS5 family transposase -
GWK63_RS02150 435006..435647 + 642 WP_166498093.1 invasion associated locus B family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 375122..508835 133713
- flank IS/Tn - - 424888..425202 314


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13248.13 Da        Isoelectric Point: 9.9064

>T152286 WP_006559873.1 NZ_CP050139:430387-430731 [Komagataeibacter rhaeticus]
MTEYAIEFDDRALREWDGLDGSIRRKFEKKLEKLVLNPHSPGNELHGDLAGFYKIKLRQDGYRLVYQVVEQRIVIFVIAV
GRREDSEIYTTATGRIPETPADRIKQPSGKSRKR

Download         Length: 345 bp

>T152286 NZ_CP066094:c2995500-2995397 [Enterobacter hormaechei]
GGCAAGGCGATTGAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9629.04 Da        Isoelectric Point: 7.3200

>AT152286 WP_010511780.1 NZ_CP050139:430131-430394 [Komagataeibacter rhaeticus]
MSAVTFRVDDALKSAAVAKLSAHGLSLSDVLRDTLAYIAETGQPPVKRRLVTDEDARLIEIVRERLADPAPRHRMTLAEL
KARHPDD

Download         Length: 264 bp

>AT152286 NZ_CP066094:2995384-2995593 [Enterobacter hormaechei]
TTTTCAAGCAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGC
TAAAAGTTGGCATTAATGCAGGCTCAATCGCCTTGCCCTTTAAGAATAGATGACGACGTCAGGTTTTCCAGTCCACAGCA
AAAGTGGTCTGAAAAAAAGCGTCAGAACATCACTAAATGTGAAAAACCGC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A841QEQ1

Antitoxin

Source ID Structure
AlphaFold DB A0A7W4J448

References