Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 443172..444031 Replicon chromosome
Accession NZ_CP050137
Organism Sphingomonas sp. CL5.1

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag F9288_RS02085 Protein ID WP_174835044.1
Coordinates 443172..443702 (-) Length 177 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID -
Locus tag F9288_RS02090 Protein ID WP_174838773.1
Coordinates 443690..444031 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F9288_RS02055 438876..439733 - 858 WP_174835040.1 3-methyl-2-oxobutanoate hydroxymethyltransferase -
F9288_RS02060 439780..440205 - 426 WP_174838771.1 hypothetical protein -
F9288_RS02065 440280..440621 - 342 WP_174835041.1 ArsC family reductase -
F9288_RS02070 440628..441035 - 408 WP_174835042.1 GNAT family acetyltransferase -
F9288_RS02075 441049..441858 - 810 WP_174835043.1 phosphatase PAP2 family protein -
F9288_RS02080 442068..442879 - 812 Protein_411 subclass B3 metallo-beta-lactamase -
F9288_RS02085 443172..443702 - 531 WP_174835044.1 GNAT family N-acetyltransferase Toxin
F9288_RS02090 443690..444031 - 342 WP_174838773.1 DUF1778 domain-containing protein Antitoxin
F9288_RS02095 444483..446777 + 2295 WP_174835045.1 AAA family ATPase -
F9288_RS02100 446896..448158 + 1263 WP_174835046.1 site-specific DNA-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element floR / tet(G) - 442791..486699 43908


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(50-151)

Antitoxin

Vibrio phage ICP1, Orf50

(24-112)


Sequences

Toxin        


Download         Length: 177 a.a.        Molecular weight: 19182.97 Da        Isoelectric Point: 6.0974

>T152283 WP_174835044.1 NZ_CP050137:c443702-443172 [Sphingomonas sp. CL5.1]
MAEIDDTPDHPELRLSAPIPLTTEHDLSAFDCGEPVLNDWLRHRALKNESRFSRTYVVCAGNRVVGYFCISAGSVERSAA
PGKMRRNAPDLIPVSIIGRLAVSLDHAGKGLGMDLLSDALRRIAVASQSIGIGAVLVQAKDEAAKRFYLRCAEFIEYPED
SRTLFLPIETVVAGFG

Download         Length: 531 bp

>T152283 NZ_CP066094:36832-37146 [Enterobacter hormaechei]
ATGCATTTAATCTCAATGAAGGCAATTTTGGATGCGGTAAGCCAGTTCCCGCAACACAGAGAAGAGCTTCTCTTTTTAGG
ACGAGTTATTGAAAAGAGCCACTGCCCGACGCCCGCTGCACTGAGAAAACTTTTCCCAACGCTGGATAACTTCAAGTATC
TTGATAAGCATTATGTTATTGATATTGCAAATAACAATCTCAGAGTAGTGGCTCTCATATTCTTTGAAAGCCAAAAGTTT
TATGTGCGCCATGTTTTTACTCATAAGGAATATGACCGTTTTACGGAGAAACATCGCACTAAGGGGAAGAAATGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12371.14 Da        Isoelectric Point: 10.7841

>AT152283 WP_174838773.1 NZ_CP050137:c444031-443690 [Sphingomonas sp. CL5.1]
MAKTRLAPSESSRSATAAVAVRASATDTKGSINLRIETGTRQLIDDAAAVLGKTRTEFMVESARRQAVDVLLDQRLFTLD
SERYDAFMQALDNPPAPGPKLKALLRRTPAWQK

Download         Length: 342 bp

>AT152283 NZ_CP066094:37146-37562 [Enterobacter hormaechei]
ATGATCGTCGCTGATGCAATGAAAGCTACGCACGCCCTTGTTGCGGCCGTTCCTTTACTGGGTGAACAGCCGAGCGAGAA
AGATTATAAGGATGCGCTTGAGCTGGTTGAGTATCTCCTTATGAACGAGCCCAATAGTCCTTTGCTGGATATTGTGTGCG
CCAGAATTAGCCATTACGAAGCTAATGGGCCAGAGATAGTCGCATTACGCAAGGAGATGGAGTCCGTTCCCGTCGGAATT
GCAGTTTTAAGAACCTTGATGGATCAATACAATCTGACGATATCGGATTTTAAGGATGAAATTGGTAGTAAATCGATGGT
TTCACGGGTTCTGAATGGTCAGAGACAGCTTACCCTGAACCATATTAAAAAGCTGGCGGCCAGATTTGGGGTATCACCTG
CGTTATTTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References