Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbE-relB/ParE-YafN
Location 821135..821721 Replicon chromosome
Accession NZ_CP050136
Organism Kingella kingae strain ATCC 23332

Toxin (Protein)


Gene name stbE Uniprot ID -
Locus tag HBA47_RS04455 Protein ID WP_154700245.1
Coordinates 821443..821721 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HBA47_RS04450 Protein ID WP_003790307.1
Coordinates 821135..821446 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HBA47_RS04420 816182..816979 + 798 WP_003790296.1 RNA methyltransferase -
HBA47_RS04425 817002..817382 + 381 WP_003790298.1 hypothetical protein -
HBA47_RS04430 817382..817909 + 528 WP_019389964.1 DNA-3-methyladenine glycosylase I -
HBA47_RS04435 817912..819072 + 1161 WP_019389965.1 oxygen-independent coproporphyrinogen III oxidase-like protein -
HBA47_RS04440 819134..819406 + 273 WP_019389966.1 ACT domain-containing protein -
HBA47_RS04445 819433..821124 + 1692 WP_154700246.1 D-lactate dehydrogenase -
HBA47_RS04450 821135..821446 + 312 WP_003790307.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
HBA47_RS04455 821443..821721 + 279 WP_154700245.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HBA47_RS04460 821773..822135 + 363 Protein_859 hypothetical protein -
HBA47_RS04465 822180..823538 + 1359 WP_060537103.1 PFL family protein -
HBA47_RS04470 823865..824173 - 309 WP_019389969.1 Grx4 family monothiol glutaredoxin -
HBA47_RS04475 824631..826490 + 1860 WP_019389970.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(33-95)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10751.51 Da        Isoelectric Point: 10.2595

>T152282 WP_154700245.1 NZ_CP050136:821443-821721 [Kingella kingae]
INYRFVVEAEDEWRKLENSIKQQFKSALAKRLENPRIPSAALHNMPDCYKIKLRKIGYRLVYRVDDNVITVTVIAIGKRD
KSVVYDVANSRL

Download         Length: 279 bp

>T152282 NZ_CP066093:c1685658-1684813 [Streptococcus salivarius]
ATGAACAAAGCAAAGTTAACAGCTCTCTGTCATAAAATTTCAAAACAAACAGGTTTAACTTTTAATTCAGTAATGACCTA
TTATTTTCTCGAAATTATTTTGAAAAAACTAAGTCAAAGTTATTATGCAGATCACTATATTTTTAAGGGTGGGTTTTTAC
TTTCGAATGTTATAGGTGTTGAGTCCCGTAGTACGGTAGATATTGACTTTTTATTTCATAAGCAGACTTTATCTGAAGAA
AATGTTCAACAGCAACTAGAAGAAATTTTAACCGAATCGAAAGATGATATTCAATTTTCTATTCAATCTATATCATCTAT
AAAAGAAAGTGATAATTATGGCGGTTATAGAGCAACCATATTATGTCAACTGGAAAATATTAAACAAATTATTCATTTAG
ATATTGCGACCGGTGATATTGTCACACCTCACCCTGTAACCTATGCTTATAAAGCCATTTTTAACGATGAAAGCTTTTCA
ATCATAGCTTACACAATTGAAACCATCTTGGCTGAAAAGTTACAAACTATTTACTCAAGAAACTTTTTGAATAGCCGCAG
CAAAGATTTCTACGATGTCTATATCCTTTCTAAGTTGAAGAAAAACGACATTGACTTTAGACAATTAAATGTTGCTTGTC
AAAGAACCTTCTCTTATCGTGAAACAGAACTTGACTATAATGAAATCGTTCAACTTATGGAATCTTTCAAAACTGACCCT
ATTCAACAACAACAATGGCAAAACTATTCAAATAAATATAGTTACACAAAAGGGATTTCTTTTTCTGAAATACTTGATGA
GATTGTTAATTTGGTAAGTGTCATAGCTTCCTCGAACAATGGTTAG

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11608.99 Da        Isoelectric Point: 4.2564

>AT152282 WP_003790307.1 NZ_CP050136:821135-821446 [Kingella kingae]
VQAALCDEKQPAHSQQYFFGRSIMQAVLADYAVSVAELKRNYASIIDEATGAVAVLNHNKPEAYLIPAQHYEQLMDYLED
LQDAQIIQERINSPSREVSLDEL

Download         Length: 312 bp

>AT152282 NZ_CP066093:c1686245-1685655 [Streptococcus salivarius]
ATGTCAAAAAAAGAACTGTTACTTGACTATCTAGATAGGAACAATGGCATGATTACCTACAAGGATTGTAAAAAAATTGG
TATTCCTACCATATATCTATCAAGACTAGAGAACGAGGGAGTTATTTTTAGGATTGCAAAAGGGATCTATTTATCTGCTA
ATGGAGACTATGATGAATACTATTTCTTTCAATATCGTTATCCTAGAACTGTCTTTTCATACATCTCCTCCCTTTATTTA
CAGGGACTTACAGATGAAATTCCACAATATTTTGAAGTAACAGTTCCCAAGGGATACCGTTTTAGGAATGCACCCTTAAA
TATCAATATTCACAGTGTTTCAAAGGAGAATTTCAACCTTGGTATCACTAGTGTAAAAACTTCTATGGGAAACACTGTTA
ATATTTATGATTTTGAACGTGTTTTGTGTGATTTTATCCGTAATAGAGATAAGATTGATACCGAGCTTTTTGTTAAAACA
CTTCAAACGTATAGTAGCTTCCCTAAAAAAAATCTTGTAAATCTCTATGAATATGCTCAAAAATTGAATATATCGGATGA
AGTTAAACGAACCTTGGAGGTGCTACTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References