Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 624573..625218 Replicon chromosome
Accession NZ_CP050136
Organism Kingella kingae strain ATCC 23332

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag HBA47_RS03345 Protein ID WP_019390174.1
Coordinates 624573..624749 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HBA47_RS03350 Protein ID WP_019390175.1
Coordinates 624796..625218 (+) Length 141 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HBA47_RS03320 619642..620724 - 1083 WP_154699919.1 hypothetical protein -
HBA47_RS03325 621005..621424 - 420 WP_019390171.1 phage virion morphogenesis protein -
HBA47_RS03335 621558..622886 - 1329 WP_032133338.1 minor capsid protein -
HBA47_RS03340 622867..624444 - 1578 WP_154699920.1 DUF935 domain-containing protein -
HBA47_RS03345 624573..624749 + 177 WP_019390174.1 type II toxin-antitoxin system HicA family toxin Toxin
HBA47_RS03350 624796..625218 + 423 WP_019390175.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HBA47_RS03355 625223..626857 - 1635 WP_038304909.1 phage terminase large subunit -
HBA47_RS03360 626900..627412 - 513 WP_019390177.1 DUF1804 family protein -
HBA47_RS03365 627414..627632 - 219 WP_019390178.1 hypothetical protein -
HBA47_RS03370 627629..627913 - 285 WP_032133341.1 hypothetical protein -
HBA47_RS03375 627916..628254 - 339 WP_019390180.1 hypothetical protein -
HBA47_RS03380 628229..628420 - 192 WP_019390181.1 hypothetical protein -
HBA47_RS03385 628431..628826 - 396 WP_154699921.1 hypothetical protein -
HBA47_RS03390 628816..629076 - 261 WP_032133344.1 hypothetical protein -
HBA47_RS03395 629080..629598 - 519 WP_154699922.1 glycoside hydrolase family 108 protein -
HBA47_RS03400 629771..630205 - 435 WP_154699923.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 601714..710662 108948


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-65)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6688.89 Da        Isoelectric Point: 10.7473

>T152281 WP_019390174.1 NZ_CP050136:624573-624749 [Kingella kingae]
MKQSEFLKWLIEQGVQTQDGTKHLKLYLNGKHSHLPRHPSKELKKGLVEGVKKQLGLK

Download         Length: 177 bp

>T152281 NZ_CP066093:c1527962-1527204 [Streptococcus salivarius]
ATGGAAATCCAAGATTATACTGGTAGCGAATTCAAACATGCTTTAGCAAGGAATCTTCGTTCTCTGACAAGAGGAAAAAA
GTCCAGTAAGCAACCTATAGCGATTTTGCTTGGAGGGCAAAGTGGTGCCGGTAAGACTACAATTCATCGTATTAAACAGA
AAGAATTTCAAGGAAATATTGTTATCATAGATGGCGATAGTTTTCGTTCTCAGCATCCACACTATTTAGAACTGCAGCAA
GAATATGGCAAAGACAGTGTTGAATACACCAAAGATTTTGCAGGCAAAATGGTAGAGTCTTTAGTAACAGAATTGAGTCA
TTTGGGATACAATCTTTTGATAGAGGGAACTTTACGAACGATTGACGTTCCAAAGGAAACAGCACAACTCTTGAAAAGTA
AGGGATATGAAGTACAATTAGCCTTGATTGCGACAAAGCCTAAGCTGTCCTATCTGAGCACCCTTATCCGATACGAAGAA
CTGTACGCTATCAATCCAAATCAAGCACGCGCAACTCCAAAAGAACATCATGATCTGATAGTGAACAATCTAGTTGAGAA
TACCCACCAGCTGGAGCAATTAGGTATCTTTGAACAAATCCAAATCTATCAACGAGATAGGACCTGTGTTTACGATTCGA
GAGATGATGAAATATCAGCAGCAACTGTTCTTCATGAATTATTGTTTGGAGAGTGGAGTCAGGTAGAAAAGGATATGCTT
AAATCTGGAGAAGAAAGATTTAAAGATTTAACTAATTGA

Antitoxin


Download         Length: 141 a.a.        Molecular weight: 15617.02 Da        Isoelectric Point: 4.6150

>AT152281 WP_019390175.1 NZ_CP050136:624796-625218 [Kingella kingae]
MFYPATFTPAEEGGFVVTFRDIPEAITQGDDLTEAREMAADVLLSAMDFYFEDKRPVPLPSKLQKGEEWVALPASVYAKV
LLLNEMLVQNISNAELARRMEIKPQEVQRIVNLNHITKIDTIAAALAQLGKHLNFSIQAA

Download         Length: 423 bp

>AT152281 NZ_CP066093:c1528438-1527962 [Streptococcus salivarius]
ATGATTGGAAAAAACATAAAATCCTTACGTAAAACACATGGCTTAACACAACCCGAATTTGCCCGAATTATAGGAATTTC
TCGAAATAGCTTAAGCCGTTATGAAAATGGAACTAGTTCAGTATCTACAGAACTAATAGACATCATTTGTCAGAAGTTTA
ATGTATCTTATGTCGATATTGTAGGAGAAGATAAAATGCTCAATCCTGTTGAAGATTATGAATTGACTTTAAAAATTGAA
ATTGTGAAAGAAAGAGGTGCTAATCTACTATCTCGACTCTATCGTTATCAAGATAGTCAGGGAATTAGCATTGATGATGA
ATCTAATCCTTGGATTTTAATGAGTAATGATCTATCTGACTTGATTCATACGAATATCTATTTAGTAGAAACTTTTGGTG
AAATAGAGAGATATAGCGGCTATTTGGATGGAATTGAACGTATGTTAGAGATATCTGAAAAACGGATGGTAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References